7CTF

Human origin recognition complex 1-5 State II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000781	cellular_component	chromosome, telomeric region
A	0000808	cellular_component	origin recognition complex
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003688	molecular_function	DNA replication origin binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005664	cellular_component	nuclear origin of replication recognition complex
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006270	biological_process	DNA replication initiation
A	0016887	molecular_function	ATP hydrolysis activity
A	0033314	biological_process	mitotic DNA replication checkpoint signaling
A	0046872	molecular_function	metal ion binding
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0000792	cellular_component	heterochromatin
B	0000808	cellular_component	origin recognition complex
B	0000939	cellular_component	inner kinetochore
B	0003688	molecular_function	DNA replication origin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005664	cellular_component	nuclear origin of replication recognition complex
B	0005813	cellular_component	centrosome
B	0006260	biological_process	DNA replication
B	0006270	biological_process	DNA replication initiation
B	0016020	cellular_component	membrane
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000808	cellular_component	origin recognition complex
C	0003677	molecular_function	DNA binding
C	0003688	molecular_function	DNA replication origin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005656	cellular_component	nuclear pre-replicative complex
C	0005664	cellular_component	nuclear origin of replication recognition complex
C	0005694	cellular_component	chromosome
C	0006260	biological_process	DNA replication
C	0006270	biological_process	DNA replication initiation
C	0006275	biological_process	regulation of DNA replication
C	0014009	biological_process	glial cell proliferation
C	0016604	cellular_component	nuclear body
C	0031261	cellular_component	DNA replication preinitiation complex
C	0061351	biological_process	neural precursor cell proliferation
D	0000166	molecular_function	nucleotide binding
D	0000781	cellular_component	chromosome, telomeric region
D	0000808	cellular_component	origin recognition complex
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005664	cellular_component	nuclear origin of replication recognition complex
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006270	biological_process	DNA replication initiation
D	0040038	biological_process	polar body extrusion after meiotic divisions
D	0051258	biological_process	protein polymerization
E	0000166	molecular_function	nucleotide binding
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000808	cellular_component	origin recognition complex
E	0003688	molecular_function	DNA replication origin binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005664	cellular_component	nuclear origin of replication recognition complex
E	0005694	cellular_component	chromosome
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0006275	biological_process	regulation of DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue ATP D 901

Chain	Residue
D	GLN31
D	GLY72
D	LYS73
D	THR74
D	MET75
D	LEU276
D	ARG277
D	HIS280
E	ARG143
D	HIS34
D	LEU37
D	PHE38
D	VAL40
D	PRO68
D	ARG69
D	GLY70
D	SER71

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site_id	AC2
Number of Residues	12
Details	binding site for residue ATP E 901

Chain	Residue
E	VAL8
E	LEU9
E	THR39
E	ALA40
E	GLY42
E	LYS43
E	THR44
E	TYR45
E	LYS126
E	TYR182
E	LEU222
E	ARG226

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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