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7CRW

Cryo-EM structure of rNLRP1-rDPP9 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0002218biological_processactivation of innate immune response
A0003690molecular_functiondouble-stranded DNA binding
A0003725molecular_functiondouble-stranded RNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0008233molecular_functionpeptidase activity
A0012501biological_processprogrammed cell death
A0016887molecular_functionATP hydrolysis activity
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0032495biological_processresponse to muramyl dipeptide
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032991cellular_componentprotein-containing complex
A0035591molecular_functionsignaling adaptor activity
A0038187molecular_functionpattern recognition receptor activity
A0042742biological_processdefense response to bacterium
A0042981biological_processregulation of apoptotic process
A0043025cellular_componentneuronal cell body
A0045087biological_processinnate immune response
A0050727biological_processregulation of inflammatory response
A0050729biological_processpositive regulation of inflammatory response
A0051245biological_processnegative regulation of cellular defense response
A0051260biological_processprotein homooligomerization
A0051402biological_processneuron apoptotic process
A0051607biological_processdefense response to virus
A0061702cellular_componentcanonical inflammasome complex
A0070269biological_processpyroptotic inflammatory response
A0071493biological_processcellular response to UV-B
A0072558cellular_componentNLRP1 inflammasome complex
A0072559cellular_componentNLRP3 inflammasome complex
A0097110molecular_functionscaffold protein binding
A0097193biological_processintrinsic apoptotic signaling pathway
A0097264biological_processself proteolysis
A0097300biological_processprogrammed necrotic cell death
A0140374biological_processantiviral innate immune response
A0140608molecular_functioncysteine-type endopeptidase activator activity
A0140639biological_processpositive regulation of pyroptotic inflammatory response
A0140693molecular_functionmolecular condensate scaffold activity
A1904784biological_processNLRP1 inflammasome complex assembly
B0002218biological_processactivation of innate immune response
B0003690molecular_functiondouble-stranded DNA binding
B0003725molecular_functiondouble-stranded RNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006954biological_processinflammatory response
B0007165biological_processsignal transduction
B0008233molecular_functionpeptidase activity
B0012501biological_processprogrammed cell death
B0016887molecular_functionATP hydrolysis activity
B0019899molecular_functionenzyme binding
B0019904molecular_functionprotein domain specific binding
B0032495biological_processresponse to muramyl dipeptide
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032991cellular_componentprotein-containing complex
B0035591molecular_functionsignaling adaptor activity
B0038187molecular_functionpattern recognition receptor activity
B0042742biological_processdefense response to bacterium
B0042981biological_processregulation of apoptotic process
B0043025cellular_componentneuronal cell body
B0045087biological_processinnate immune response
B0050727biological_processregulation of inflammatory response
B0050729biological_processpositive regulation of inflammatory response
B0051245biological_processnegative regulation of cellular defense response
B0051260biological_processprotein homooligomerization
B0051402biological_processneuron apoptotic process
B0051607biological_processdefense response to virus
B0061702cellular_componentcanonical inflammasome complex
B0070269biological_processpyroptotic inflammatory response
B0071493biological_processcellular response to UV-B
B0072558cellular_componentNLRP1 inflammasome complex
B0072559cellular_componentNLRP3 inflammasome complex
B0097110molecular_functionscaffold protein binding
B0097193biological_processintrinsic apoptotic signaling pathway
B0097264biological_processself proteolysis
B0097300biological_processprogrammed necrotic cell death
B0140374biological_processantiviral innate immune response
B0140608molecular_functioncysteine-type endopeptidase activator activity
B0140639biological_processpositive regulation of pyroptotic inflammatory response
B0140693molecular_functionmolecular condensate scaffold activity
B1904784biological_processNLRP1 inflammasome complex assembly
C0004177molecular_functionaminopeptidase activity
C0005829cellular_componentcytosol
C0005874cellular_componentmicrotubule
C0006508biological_processproteolysis
C0008236molecular_functionserine-type peptidase activity
C0008239molecular_functiondipeptidyl-peptidase activity
C0031252cellular_componentcell leading edge
C0042802molecular_functionidentical protein binding
C0043069biological_processnegative regulation of programmed cell death
C0070269biological_processpyroptotic inflammatory response
D0004177molecular_functionaminopeptidase activity
D0005829cellular_componentcytosol
D0005874cellular_componentmicrotubule
D0006508biological_processproteolysis
D0008236molecular_functionserine-type peptidase activity
D0008239molecular_functiondipeptidyl-peptidase activity
D0031252cellular_componentcell leading edge
D0042802molecular_functionidentical protein binding
D0043069biological_processnegative regulation of programmed cell death
D0070269biological_processpyroptotic inflammatory response
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00136
ChainResidueDetails
AGLY181
BGLY181

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Trigger for autolytic processing => ECO:0000269|PubMed:33731929
ChainResidueDetails
AHIS942
BHIS942

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by autolysis => ECO:0000255|PROSITE-ProRule:PRU01174, ECO:0000269|PubMed:33731929
ChainResidueDetails
APHE968
BPHE968

227111

PDB entries from 2024-11-06

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