7CRW

Cryo-EM structure of rNLRP1-rDPP9 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002218	biological_process	activation of innate immune response
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006954	biological_process	inflammatory response
A	0032991	cellular_component	protein-containing complex
A	0038187	molecular_function	pattern recognition receptor activity
A	0042981	biological_process	regulation of apoptotic process
A	0043025	cellular_component	neuronal cell body
A	0045087	biological_process	innate immune response
A	0051245	biological_process	negative regulation of cellular defense response
A	0051260	biological_process	protein homooligomerization
A	0061702	cellular_component	canonical inflammasome complex
A	0072558	cellular_component	NLRP1 inflammasome complex
A	0072559	cellular_component	NLRP3 inflammasome complex
A	0097110	molecular_function	scaffold protein binding
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	0140608	molecular_function	cysteine-type endopeptidase activator activity
A	0140639	biological_process	positive regulation of pyroptotic inflammatory response
B	0002218	biological_process	activation of innate immune response
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006954	biological_process	inflammatory response
B	0032991	cellular_component	protein-containing complex
B	0038187	molecular_function	pattern recognition receptor activity
B	0042981	biological_process	regulation of apoptotic process
B	0043025	cellular_component	neuronal cell body
B	0045087	biological_process	innate immune response
B	0051245	biological_process	negative regulation of cellular defense response
B	0051260	biological_process	protein homooligomerization
B	0061702	cellular_component	canonical inflammasome complex
B	0072558	cellular_component	NLRP1 inflammasome complex
B	0072559	cellular_component	NLRP3 inflammasome complex
B	0097110	molecular_function	scaffold protein binding
B	0097193	biological_process	intrinsic apoptotic signaling pathway
B	0140608	molecular_function	cysteine-type endopeptidase activator activity
B	0140639	biological_process	positive regulation of pyroptotic inflammatory response
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
C	0008239	molecular_function	dipeptidyl-peptidase activity
D	0006508	biological_process	proteolysis
D	0008236	molecular_function	serine-type peptidase activity
D	0008239	molecular_function	dipeptidyl-peptidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	133
Details	Region: {"description":"ZU5","evidences":[{"source":"UniProtKB","id":"Q9C000","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Trigger for autolytic processing","evidences":[{"source":"UniProtKB","id":"Q9C000","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PROSITE-ProRule","id":"PRU01174","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---