7CR1

human KCNQ2 in complex with ztz240

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GB9 A 801

Chain	Residue
A	ILE134
A	PHE137
A	PHE168
A	ILE171
A	ASP172
A	VAL175
A	SER179
A	ARG210

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GB9 B 801

Chain	Residue
B	PHE137
B	PHE168
B	ILE171
B	ASP172
B	VAL175
B	SER179
B	ARG210
B	ILE134

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GB9 C 801

Chain	Residue
C	ILE134
C	PHE137
C	PHE168
C	ILE171
C	ASP172
C	VAL175
C	SER179
C	ARG210

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GB9 D 801

Chain	Residue
D	ILE134
D	PHE137
D	PHE168
D	ILE171
D	ASP172
D	VAL175
D	SER179
D	ARG210

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	112
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	48
Details	Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	404
Details	Region: {"description":"Mediates interaction with SLC5A3/SMIT1","evidences":[{"source":"UniProtKB","id":"O88943","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8J01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8W4U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8W4U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16319223","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---