7CR1

human KCNQ2 in complex with ztz240

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GB9 A 801

Chain	Residue
A	ILE134
A	PHE137
A	PHE168
A	ILE171
A	ASP172
A	VAL175
A	SER179
A	ARG210

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GB9 B 801

Chain	Residue
B	PHE137
B	PHE168
B	ILE171
B	ASP172
B	VAL175
B	SER179
B	ARG210
B	ILE134

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GB9 C 801

Chain	Residue
C	ILE134
C	PHE137
C	PHE168
C	ILE171
C	ASP172
C	VAL175
C	SER179
C	ARG210

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GB9 D 801

Chain	Residue
D	ILE134
D	PHE137
D	PHE168
D	ILE171
D	ASP172
D	VAL175
D	SER179
D	ARG210

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:32884139, ECO:0007744|PDB:7CR3

Chain	Residue	Details
A	TRP91-SER113
B	TRP91-SER113
C	TRP91-SER113
D	TRP91-SER113

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	THR114-GLU123
C	ALA184-ALA196
C	GLU254-THR263
C	THR277-THR287
D	THR114-GLU123
D	ALA184-ALA196
D	GLU254-THR263
D	THR277-THR287
A	ALA184-ALA196
A	GLU254-THR263
A	THR277-THR287
B	THR114-GLU123
B	ALA184-ALA196
B	GLU254-THR263
B	THR277-THR287
C	THR114-GLU123

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:32884139, ECO:0007744|PDB:7CR3

Chain	Residue	Details
A	GLY124-ILE145
B	GLY124-ILE145
C	GLY124-ILE145
D	GLY124-ILE145

---

site_id	SWS_FT_FI4
Number of Residues	112
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP146-PHE163
A	GLY216-ALA227
B	TRP146-PHE163
B	GLY216-ALA227
C	TRP146-PHE163
C	GLY216-ALA227
D	TRP146-PHE163
D	GLY216-ALA227

---

site_id	SWS_FT_FI5
Number of Residues	76
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:32884139, ECO:0007744|PDB:7CR3

Chain	Residue	Details
A	ALA164-LEU183
B	ALA164-LEU183
C	ALA164-LEU183
D	ALA164-LEU183

---

site_id	SWS_FT_FI6
Number of Residues	72
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:32884139, ECO:0007744|PDB:7CR3

Chain	Residue	Details
A	LEU197-GLY215
B	LEU197-GLY215
C	LEU197-GLY215
D	LEU197-GLY215

---

site_id	SWS_FT_FI7
Number of Residues	100
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:32884139, ECO:0007744|PDB:7CR3

Chain	Residue	Details
A	HIS228-ALA253
B	HIS228-ALA253
C	HIS228-ALA253
D	HIS228-ALA253

---

site_id	SWS_FT_FI8
Number of Residues	48
Details	INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000269|PubMed:32884139, ECO:0007744|PDB:7CR3

Chain	Residue	Details
A	TYR264-THR276
B	TYR264-THR276
C	TYR264-THR276
D	TYR264-THR276

---

site_id	SWS_FT_FI9
Number of Residues	104
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:32884139, ECO:0007744|PDB:7CR3

Chain	Residue	Details
A	TRP288-SER314
B	TRP288-SER314
C	TRP288-SER314
D	TRP288-SER314

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:37857637, ECO:0007744|PDB:8J01, ECO:0007744|PDB:8W4U

Chain	Residue	Details
A	ARG214
A	LYS327
B	ARG214
B	LYS327
C	ARG214
C	LYS327
D	ARG214
D	LYS327

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:37857637, ECO:0007744|PDB:8W4U

Chain	Residue	Details
A	LYS230
B	LYS230
C	LYS230
D	LYS230

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:16319223

Chain	Residue	Details
A	THR217
B	THR217
C	THR217
D	THR217

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z351

Chain	Residue	Details
A	SER466
B	SER478
C	SER466
C	SER468
C	SER472
C	SER476
C	SER478
D	SER466
D	SER468
D	SER472
D	SER476
A	SER468
D	SER478
A	SER472
A	SER476
A	SER478
B	SER466
B	SER468
B	SER472
B	SER476

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O88943

Chain	Residue	Details
A	SER507
A	SER672
B	SER507
B	SER672
C	SER507
C	SER672
D	SER507
D	SER672

---