7CQ6
Structure of the human CLCN7-OSTM1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005254 | molecular_function | chloride channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005764 | cellular_component | lysosome |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006821 | biological_process | chloride transport |
| C | 0009268 | biological_process | response to pH |
| C | 0015108 | molecular_function | chloride transmembrane transporter activity |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0030321 | biological_process | transepithelial chloride transport |
| C | 0034707 | cellular_component | chloride channel complex |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0062158 | molecular_function | chloride:proton antiporter activity |
| C | 1902476 | biological_process | chloride transmembrane transport |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005254 | molecular_function | chloride channel activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005764 | cellular_component | lysosome |
| D | 0005765 | cellular_component | lysosomal membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006821 | biological_process | chloride transport |
| D | 0009268 | biological_process | response to pH |
| D | 0015108 | molecular_function | chloride transmembrane transporter activity |
| D | 0015297 | molecular_function | antiporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0030321 | biological_process | transepithelial chloride transport |
| D | 0034707 | cellular_component | chloride channel complex |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0062158 | molecular_function | chloride:proton antiporter activity |
| D | 1902476 | biological_process | chloride transmembrane transport |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 444 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 104 |
| Details | Intramembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Intramembrane: {"description":"Note=Loop between two helices","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Site: {"description":"Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Site: {"description":"Mediates proton transfer from the protein to the inner aqueous phase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
