Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CP9

Cryo-EM structure of human mitochondrial translocase TOM complex at 3.0 angstrom.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005742	cellular_component	mitochondrial outer membrane translocase complex
A	0006626	biological_process	protein targeting to mitochondrion
A	0015031	biological_process	protein transport
A	0045040	biological_process	protein insertion into mitochondrial outer membrane
A	0140596	cellular_component	TOM complex
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005742	cellular_component	mitochondrial outer membrane translocase complex
B	0006626	biological_process	protein targeting to mitochondrion
B	0015031	biological_process	protein transport
B	0045040	biological_process	protein insertion into mitochondrial outer membrane
B	0140596	cellular_component	TOM complex
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005742	cellular_component	mitochondrial outer membrane translocase complex
C	0015031	biological_process	protein transport
C	0045040	biological_process	protein insertion into mitochondrial outer membrane
C	0140596	cellular_component	TOM complex
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005742	cellular_component	mitochondrial outer membrane translocase complex
D	0015031	biological_process	protein transport
D	0045040	biological_process	protein insertion into mitochondrial outer membrane
D	0140596	cellular_component	TOM complex
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005742	cellular_component	mitochondrial outer membrane translocase complex
E	0006626	biological_process	protein targeting to mitochondrion
E	0008320	molecular_function	protein transmembrane transporter activity
E	0015031	biological_process	protein transport
E	0030150	biological_process	protein import into mitochondrial matrix
E	0031647	biological_process	regulation of protein stability
E	0045040	biological_process	protein insertion into mitochondrial outer membrane
E	0098779	biological_process	positive regulation of mitophagy in response to mitochondrial depolarization
E	0140596	cellular_component	TOM complex
E	1903955	biological_process	positive regulation of protein targeting to mitochondrion
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005742	cellular_component	mitochondrial outer membrane translocase complex
F	0006626	biological_process	protein targeting to mitochondrion
F	0008320	molecular_function	protein transmembrane transporter activity
F	0015031	biological_process	protein transport
F	0030150	biological_process	protein import into mitochondrial matrix
F	0031647	biological_process	regulation of protein stability
F	0045040	biological_process	protein insertion into mitochondrial outer membrane
F	0098779	biological_process	positive regulation of mitophagy in response to mitochondrial depolarization
F	0140596	cellular_component	TOM complex
F	1903955	biological_process	positive regulation of protein targeting to mitochondrion
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005742	cellular_component	mitochondrial outer membrane translocase complex
G	0006626	biological_process	protein targeting to mitochondrion
G	0006886	biological_process	intracellular protein transport
G	0008320	molecular_function	protein transmembrane transporter activity
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0030943	molecular_function	mitochondrion targeting sequence binding
G	0045040	biological_process	protein insertion into mitochondrial outer membrane
G	0071806	biological_process	protein transmembrane transport
G	0140596	cellular_component	TOM complex
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005742	cellular_component	mitochondrial outer membrane translocase complex
H	0006626	biological_process	protein targeting to mitochondrion
H	0006886	biological_process	intracellular protein transport
H	0008320	molecular_function	protein transmembrane transporter activity
H	0015031	biological_process	protein transport
H	0016020	cellular_component	membrane
H	0030943	molecular_function	mitochondrion targeting sequence binding
H	0045040	biological_process	protein insertion into mitochondrial outer membrane
H	0071806	biological_process	protein transmembrane transport
H	0140596	cellular_component	TOM complex
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005742	cellular_component	mitochondrial outer membrane translocase complex
I	0005743	cellular_component	mitochondrial inner membrane
I	0005829	cellular_component	cytosol
I	0006626	biological_process	protein targeting to mitochondrion
I	0006811	biological_process	monoatomic ion transport
I	0008320	molecular_function	protein transmembrane transporter activity
I	0015031	biological_process	protein transport
I	0015288	molecular_function	porin activity
I	0016020	cellular_component	membrane
I	0030150	biological_process	protein import into mitochondrial matrix
I	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
I	0045040	biological_process	protein insertion into mitochondrial outer membrane
I	0046930	cellular_component	pore complex
I	0055085	biological_process	transmembrane transport
I	0140596	cellular_component	TOM complex
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0005742	cellular_component	mitochondrial outer membrane translocase complex
J	0005743	cellular_component	mitochondrial inner membrane
J	0005829	cellular_component	cytosol
J	0006626	biological_process	protein targeting to mitochondrion
J	0006811	biological_process	monoatomic ion transport
J	0008320	molecular_function	protein transmembrane transporter activity
J	0015031	biological_process	protein transport
J	0015288	molecular_function	porin activity
J	0016020	cellular_component	membrane
J	0030150	biological_process	protein import into mitochondrial matrix
J	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
J	0045040	biological_process	protein insertion into mitochondrial outer membrane
J	0046930	cellular_component	pore complex
J	0055085	biological_process	transmembrane transport
J	0140596	cellular_component	TOM complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue PC1 C 101

Chain	Residue
C	ARG38
I	ARG348
C	ARG43
C	ASN44
C	LEU47
C	ASN48
C	LEU51
I	SER320
I	ASN321
I	TRP322

site_id	AC2
Number of Residues	7
Details	binding site for residue PC1 E 101

Chain	Residue
E	PHE16
E	GLN20
J	LYS184
J	PHE185
J	PRO208
J	ASP209
J	VAL210

site_id	AC3
Number of Residues	3
Details	binding site for residue PC1 E 102

Chain	Residue
E	PHE36
E	LYS37
E	GLU46

site_id	AC4
Number of Residues	7
Details	binding site for residue PC1 F 101

Chain	Residue
F	PHE16
F	GLN20
I	LYS184
I	PHE185
I	TRP188
I	PRO208
I	ASP209

site_id	AC5
Number of Residues	2
Details	binding site for residue PC1 F 102

Chain	Residue
F	PHE36
F	GLU46

site_id	AC6
Number of Residues	10
Details	binding site for residue PC1 G 201

Chain	Residue
G	MET93
G	GLU102
G	LYS105
H	MET93
H	GLU102
I	LYS330
I	LEU332
J	LYS330
J	PRO333
J	LEU358

site_id	AC7
Number of Residues	6
Details	binding site for residue PC1 G 202

Chain	Residue
G	ARG82
G	LEU85
G	TRP86
G	PC1203
J	SER127
J	ASN156

site_id	AC8
Number of Residues	7
Details	binding site for residue PC1 G 203

Chain	Residue
E	LEU53
G	TYR78
G	ARG79
G	ARG82
G	PC1202
J	ASP155
J	ASN156

site_id	AC9
Number of Residues	7
Details	binding site for residue PC1 H 201

Chain	Residue
F	LEU53
H	ARG82
H	LEU85
H	TRP86
H	PC1202
I	ASN156
J	ASN350

site_id	AD1
Number of Residues	7
Details	binding site for residue PC1 H 202

Chain	Residue
H	TYR78
H	ARG79
H	ARG82
H	PC1201
I	ASP155
I	ASN156
I	SER157

site_id	AD2
Number of Residues	9
Details	binding site for residue PC1 J 401

Chain	Residue
D	ARG38
D	ARG43
D	LEU47
D	LEU51
J	THR297
J	SER320
J	ASN321
J	TRP322
J	ARG348

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	162
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
G	ALA2-ALA83
H	ALA2-ALA83

site_id	SWS_FT_FI2
Number of Residues	38
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
G	ALA84-THR103
H	ALA84-THR103

site_id	SWS_FT_FI3
Number of Residues	76
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000255

Chain	Residue	Details
G	GLU104-ILE142
H	GLU104-ILE142
B	LYS10

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.6, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
G	ALA2
H	ALA2

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17081983, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
G	SER15
H	SER15

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
G	THR43
H	THR43

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q9CPQ3

Chain	Residue	Details
G	SER45
H	SER45

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)