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7COC

Ternary complex of DNA polymerase Mu (K438A/Q441A) with 1-nt gapped DNA (T:dGMPNPP)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0006281biological_processDNA repair
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006310biological_processDNA recombination
A0016779molecular_functionnucleotidyltransferase activity
A0034061molecular_functionDNA polymerase activity
A0046872molecular_functionmetal ion binding
A0071897biological_processDNA biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00522
Number of Residues20
DetailsDNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP
ChainResidueDetails
AGLY319-PRO338

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP330
AASP332
AALA430

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Responsible for the low discrimination between dNTP and rNTP
ChainResidueDetails
AARG445

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER12

226707

PDB entries from 2024-10-30

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