Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CMH

The LAT2-4F2hc complex in complex with tryptophan

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005975	biological_process	carbohydrate metabolic process
A	0006865	biological_process	amino acid transport
B	0003333	biological_process	amino acid transmembrane transport
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006865	biological_process	amino acid transport
B	0009925	cellular_component	basal plasma membrane
B	0015101	molecular_function	organic cation transmembrane transporter activity
B	0015171	molecular_function	amino acid transmembrane transporter activity
B	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
B	0015179	molecular_function	L-amino acid transmembrane transporter activity
B	0015180	molecular_function	L-alanine transmembrane transporter activity
B	0015187	molecular_function	glycine transmembrane transporter activity
B	0015190	molecular_function	L-leucine transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015349	molecular_function	thyroid hormone transmembrane transporter activity
B	0015804	biological_process	neutral amino acid transport
B	0015807	biological_process	L-amino acid transport
B	0015816	biological_process	glycine transport
B	0015820	biological_process	L-leucine transport
B	0015827	biological_process	tryptophan transport
B	0015829	biological_process	valine transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0019534	molecular_function	toxin transmembrane transporter activity
B	0022857	molecular_function	transmembrane transporter activity
B	0031528	cellular_component	microvillus membrane
B	0035524	biological_process	proline transmembrane transport
B	0042605	molecular_function	peptide antigen binding
B	0046982	molecular_function	protein heterodimerization activity
B	0055085	biological_process	transmembrane transport
B	0070327	biological_process	thyroid hormone transport
B	0089718	biological_process	amino acid import across plasma membrane
B	0150104	biological_process	transport across blood-brain barrier
B	1903801	biological_process	L-leucine import across plasma membrane
B	1904273	biological_process	L-alanine import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	424
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"11121428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19065266","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	60
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	73
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	32
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Site: {"description":"Important for substrate specificity","evidences":[{"source":"PubMed","id":"34848541","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)