7CM6

NAD+-bound Sarm1 in the self-inhibited state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003953	molecular_function	NAD+ nucleosidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0007165	biological_process	signal transduction
A	0007399	biological_process	nervous system development
A	0009749	biological_process	response to glucose
A	0009986	cellular_component	cell surface
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0019677	biological_process	NAD catabolic process
A	0030154	biological_process	cell differentiation
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0032991	cellular_component	protein-containing complex
A	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
A	0035591	molecular_function	signaling adaptor activity
A	0042995	cellular_component	cell projection
A	0043523	biological_process	regulation of neuron apoptotic process
A	0045087	biological_process	innate immune response
A	0045202	cellular_component	synapse
A	0048678	biological_process	response to axon injury
A	0048814	biological_process	regulation of dendrite morphogenesis
A	0050135	molecular_function	NADP+ nucleosidase activity
A	0050877	biological_process	nervous system process
A	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating
A	0070585	biological_process	protein localization to mitochondrion
B	0003953	molecular_function	NAD+ nucleosidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0007165	biological_process	signal transduction
B	0007399	biological_process	nervous system development
B	0009749	biological_process	response to glucose
B	0009986	cellular_component	cell surface
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0019677	biological_process	NAD catabolic process
B	0030154	biological_process	cell differentiation
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0032991	cellular_component	protein-containing complex
B	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
B	0035591	molecular_function	signaling adaptor activity
B	0042995	cellular_component	cell projection
B	0043523	biological_process	regulation of neuron apoptotic process
B	0045087	biological_process	innate immune response
B	0045202	cellular_component	synapse
B	0048678	biological_process	response to axon injury
B	0048814	biological_process	regulation of dendrite morphogenesis
B	0050135	molecular_function	NADP+ nucleosidase activity
B	0050877	biological_process	nervous system process
B	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating
B	0070585	biological_process	protein localization to mitochondrion
C	0003953	molecular_function	NAD+ nucleosidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005829	cellular_component	cytosol
C	0005874	cellular_component	microtubule
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0009749	biological_process	response to glucose
C	0009986	cellular_component	cell surface
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0019677	biological_process	NAD catabolic process
C	0030154	biological_process	cell differentiation
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0032991	cellular_component	protein-containing complex
C	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
C	0035591	molecular_function	signaling adaptor activity
C	0042995	cellular_component	cell projection
C	0043523	biological_process	regulation of neuron apoptotic process
C	0045087	biological_process	innate immune response
C	0045202	cellular_component	synapse
C	0048678	biological_process	response to axon injury
C	0048814	biological_process	regulation of dendrite morphogenesis
C	0050135	molecular_function	NADP+ nucleosidase activity
C	0050877	biological_process	nervous system process
C	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating
C	0070585	biological_process	protein localization to mitochondrion
D	0003953	molecular_function	NAD+ nucleosidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005829	cellular_component	cytosol
D	0005874	cellular_component	microtubule
D	0007165	biological_process	signal transduction
D	0007399	biological_process	nervous system development
D	0009749	biological_process	response to glucose
D	0009986	cellular_component	cell surface
D	0015630	cellular_component	microtubule cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0019677	biological_process	NAD catabolic process
D	0030154	biological_process	cell differentiation
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0032991	cellular_component	protein-containing complex
D	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
D	0035591	molecular_function	signaling adaptor activity
D	0042995	cellular_component	cell projection
D	0043523	biological_process	regulation of neuron apoptotic process
D	0045087	biological_process	innate immune response
D	0045202	cellular_component	synapse
D	0048678	biological_process	response to axon injury
D	0048814	biological_process	regulation of dendrite morphogenesis
D	0050135	molecular_function	NADP+ nucleosidase activity
D	0050877	biological_process	nervous system process
D	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating
D	0070585	biological_process	protein localization to mitochondrion
E	0003953	molecular_function	NAD+ nucleosidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005829	cellular_component	cytosol
E	0005874	cellular_component	microtubule
E	0007165	biological_process	signal transduction
E	0007399	biological_process	nervous system development
E	0009749	biological_process	response to glucose
E	0009986	cellular_component	cell surface
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0019677	biological_process	NAD catabolic process
E	0030154	biological_process	cell differentiation
E	0030424	cellular_component	axon
E	0030425	cellular_component	dendrite
E	0032991	cellular_component	protein-containing complex
E	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
E	0035591	molecular_function	signaling adaptor activity
E	0042995	cellular_component	cell projection
E	0043523	biological_process	regulation of neuron apoptotic process
E	0045087	biological_process	innate immune response
E	0045202	cellular_component	synapse
E	0048678	biological_process	response to axon injury
E	0048814	biological_process	regulation of dendrite morphogenesis
E	0050135	molecular_function	NADP+ nucleosidase activity
E	0050877	biological_process	nervous system process
E	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating
E	0070585	biological_process	protein localization to mitochondrion
F	0003953	molecular_function	NAD+ nucleosidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005829	cellular_component	cytosol
F	0005874	cellular_component	microtubule
F	0007165	biological_process	signal transduction
F	0007399	biological_process	nervous system development
F	0009749	biological_process	response to glucose
F	0009986	cellular_component	cell surface
F	0015630	cellular_component	microtubule cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0019677	biological_process	NAD catabolic process
F	0030154	biological_process	cell differentiation
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0032991	cellular_component	protein-containing complex
F	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
F	0035591	molecular_function	signaling adaptor activity
F	0042995	cellular_component	cell projection
F	0043523	biological_process	regulation of neuron apoptotic process
F	0045087	biological_process	innate immune response
F	0045202	cellular_component	synapse
F	0048678	biological_process	response to axon injury
F	0048814	biological_process	regulation of dendrite morphogenesis
F	0050135	molecular_function	NADP+ nucleosidase activity
F	0050877	biological_process	nervous system process
F	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating
F	0070585	biological_process	protein localization to mitochondrion
G	0003953	molecular_function	NAD+ nucleosidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005829	cellular_component	cytosol
G	0005874	cellular_component	microtubule
G	0007165	biological_process	signal transduction
G	0007399	biological_process	nervous system development
G	0009749	biological_process	response to glucose
G	0009986	cellular_component	cell surface
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0019677	biological_process	NAD catabolic process
G	0030154	biological_process	cell differentiation
G	0030424	cellular_component	axon
G	0030425	cellular_component	dendrite
G	0032991	cellular_component	protein-containing complex
G	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
G	0035591	molecular_function	signaling adaptor activity
G	0042995	cellular_component	cell projection
G	0043523	biological_process	regulation of neuron apoptotic process
G	0045087	biological_process	innate immune response
G	0045202	cellular_component	synapse
G	0048678	biological_process	response to axon injury
G	0048814	biological_process	regulation of dendrite morphogenesis
G	0050135	molecular_function	NADP+ nucleosidase activity
G	0050877	biological_process	nervous system process
G	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating
G	0070585	biological_process	protein localization to mitochondrion
H	0003953	molecular_function	NAD+ nucleosidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005829	cellular_component	cytosol
H	0005874	cellular_component	microtubule
H	0007165	biological_process	signal transduction
H	0007399	biological_process	nervous system development
H	0009749	biological_process	response to glucose
H	0009986	cellular_component	cell surface
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0019677	biological_process	NAD catabolic process
H	0030154	biological_process	cell differentiation
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0032991	cellular_component	protein-containing complex
H	0034128	biological_process	negative regulation of MyD88-independent toll-like receptor signaling pathway
H	0035591	molecular_function	signaling adaptor activity
H	0042995	cellular_component	cell projection
H	0043523	biological_process	regulation of neuron apoptotic process
H	0045087	biological_process	innate immune response
H	0045202	cellular_component	synapse
H	0048678	biological_process	response to axon injury
H	0048814	biological_process	regulation of dendrite morphogenesis
H	0050135	molecular_function	NADP+ nucleosidase activity
H	0050877	biological_process	nervous system process
H	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating
H	0070585	biological_process	protein localization to mitochondrion

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue NAD A 1000

Chain	Residue
A	TRP103
A	LYS193
A	GLN320
A	GLY321
A	GLY323
A	ARG110
A	GLU149
A	GLN150
A	ILE151
A	LEU152
A	VAL153
A	ARG157
A	HIS190

---

site_id	AC2
Number of Residues	13
Details	binding site for residue NAD B 1000

Chain	Residue
B	TRP103
B	ARG110
B	GLU149
B	GLN150
B	ILE151
B	LEU152
B	VAL153
B	ARG157
B	HIS190
B	LYS193
B	GLN320
B	GLY321
B	GLY323

---

site_id	AC3
Number of Residues	13
Details	binding site for residue NAD C 1000

Chain	Residue
C	TRP103
C	ARG110
C	GLU149
C	GLN150
C	ILE151
C	LEU152
C	VAL153
C	ARG157
C	HIS190
C	LYS193
C	GLN320
C	GLY321
C	GLY323

---

site_id	AC4
Number of Residues	13
Details	binding site for residue NAD D 1000

Chain	Residue
D	TRP103
D	ARG110
D	GLU149
D	GLN150
D	ILE151
D	LEU152
D	VAL153
D	ARG157
D	HIS190
D	LYS193
D	GLN320
D	GLY321
D	GLY323

---

site_id	AC5
Number of Residues	13
Details	binding site for residue NAD E 1000

Chain	Residue
E	TRP103
E	ARG110
E	GLU149
E	GLN150
E	ILE151
E	LEU152
E	VAL153
E	ARG157
E	HIS190
E	LYS193
E	GLN320
E	GLY321
E	GLY323

---

site_id	AC6
Number of Residues	12
Details	binding site for residue NAD F 1000

Chain	Residue
F	TRP103
F	ARG110
F	GLU149
F	GLN150
F	ILE151
F	LEU152
F	ARG157
F	HIS190
F	LYS193
F	GLN320
F	GLY321
F	GLY323

---

site_id	AC7
Number of Residues	13
Details	binding site for residue NAD G 1000

Chain	Residue
G	TRP103
G	ARG110
G	GLU149
G	GLN150
G	ILE151
G	LEU152
G	VAL153
G	ARG157
G	HIS190
G	LYS193
G	GLN320
G	GLY321
G	GLY323

---

site_id	AC8
Number of Residues	13
Details	binding site for residue NAD H 1000

Chain	Residue
H	LYS193
H	GLN320
H	GLY321
H	GLY323
H	TRP103
H	ARG110
H	GLU149
H	GLN150
H	ILE151
H	LEU152
H	VAL153
H	ARG157
H	HIS190

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00204, ECO:0000305|PubMed:28334607, ECO:0000305|PubMed:31439792, ECO:0000305|PubMed:31439793

Chain	Residue	Details
A	GLU642
B	GLU642
C	GLU642
D	GLU642
E	GLU642
F	GLU642
G	GLU642
H	GLU642

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:33053563, ECO:0007744|PDB:7CM6, ECO:0007744|PDB:7CM7

Chain	Residue	Details
A	TRP103
C	ARG110
C	GLU149
C	HIS190
D	TRP103
D	ARG110
D	GLU149
D	HIS190
E	TRP103
E	ARG110
E	GLU149
A	ARG110
E	HIS190
F	TRP103
F	ARG110
F	GLU149
F	HIS190
G	TRP103
G	ARG110
G	GLU149
G	HIS190
H	TRP103
A	GLU149
H	ARG110
H	GLU149
H	HIS190
A	HIS190
B	TRP103
B	ARG110
B	GLU149
B	HIS190
C	TRP103

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000305|PubMed:31439792

Chain	Residue	Details
A	ARG569
E	GLU599
F	ARG569
F	GLU599
G	ARG569
G	GLU599
H	ARG569
H	GLU599
A	GLU599
B	ARG569
B	GLU599
C	ARG569
C	GLU599
D	ARG569
D	GLU599
E	ARG569

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:30333228

Chain	Residue	Details
A	SER548
B	SER548
C	SER548
D	SER548
E	SER548
F	SER548
G	SER548
H	SER548

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6PDS3

Chain	Residue	Details
A	SER558
B	SER558
C	SER558
D	SER558
E	SER558
F	SER558
G	SER558
H	SER558

---