7CK8

Crystal structure of human ferritin heavy chain mutant C90S/C102S/C130S

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
A	0110076	biological_process	negative regulation of ferroptosis
A	0140315	molecular_function	iron ion sequestering activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0005829	cellular_component	cytosol
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0016491	molecular_function	oxidoreductase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0042802	molecular_function	identical protein binding
B	0044754	cellular_component	autolysosome
B	0046872	molecular_function	metal ion binding
B	0048147	biological_process	negative regulation of fibroblast proliferation
B	0070062	cellular_component	extracellular exosome
B	0070288	cellular_component	ferritin complex
B	0110076	biological_process	negative regulation of ferroptosis
B	0140315	molecular_function	iron ion sequestering activity
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016491	molecular_function	oxidoreductase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0042802	molecular_function	identical protein binding
C	0044754	cellular_component	autolysosome
C	0046872	molecular_function	metal ion binding
C	0048147	biological_process	negative regulation of fibroblast proliferation
C	0070062	cellular_component	extracellular exosome
C	0070288	cellular_component	ferritin complex
C	0110076	biological_process	negative regulation of ferroptosis
C	0140315	molecular_function	iron ion sequestering activity
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0005829	cellular_component	cytosol
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016491	molecular_function	oxidoreductase activity
D	0031410	cellular_component	cytoplasmic vesicle
D	0042802	molecular_function	identical protein binding
D	0044754	cellular_component	autolysosome
D	0046872	molecular_function	metal ion binding
D	0048147	biological_process	negative regulation of fibroblast proliferation
D	0070062	cellular_component	extracellular exosome
D	0070288	cellular_component	ferritin complex
D	0110076	biological_process	negative regulation of ferroptosis
D	0140315	molecular_function	iron ion sequestering activity
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0004322	molecular_function	ferroxidase activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005776	cellular_component	autophagosome
E	0005829	cellular_component	cytosol
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016491	molecular_function	oxidoreductase activity
E	0031410	cellular_component	cytoplasmic vesicle
E	0042802	molecular_function	identical protein binding
E	0044754	cellular_component	autolysosome
E	0046872	molecular_function	metal ion binding
E	0048147	biological_process	negative regulation of fibroblast proliferation
E	0070062	cellular_component	extracellular exosome
E	0070288	cellular_component	ferritin complex
E	0110076	biological_process	negative regulation of ferroptosis
E	0140315	molecular_function	iron ion sequestering activity
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0004322	molecular_function	ferroxidase activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005776	cellular_component	autophagosome
F	0005829	cellular_component	cytosol
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0016491	molecular_function	oxidoreductase activity
F	0031410	cellular_component	cytoplasmic vesicle
F	0042802	molecular_function	identical protein binding
F	0044754	cellular_component	autolysosome
F	0046872	molecular_function	metal ion binding
F	0048147	biological_process	negative regulation of fibroblast proliferation
F	0070062	cellular_component	extracellular exosome
F	0070288	cellular_component	ferritin complex
F	0110076	biological_process	negative regulation of ferroptosis
F	0140315	molecular_function	iron ion sequestering activity
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0004322	molecular_function	ferroxidase activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005776	cellular_component	autophagosome
G	0005829	cellular_component	cytosol
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0008285	biological_process	negative regulation of cell population proliferation
G	0016491	molecular_function	oxidoreductase activity
G	0031410	cellular_component	cytoplasmic vesicle
G	0042802	molecular_function	identical protein binding
G	0044754	cellular_component	autolysosome
G	0046872	molecular_function	metal ion binding
G	0048147	biological_process	negative regulation of fibroblast proliferation
G	0070062	cellular_component	extracellular exosome
G	0070288	cellular_component	ferritin complex
G	0110076	biological_process	negative regulation of ferroptosis
G	0140315	molecular_function	iron ion sequestering activity
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0004322	molecular_function	ferroxidase activity
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005776	cellular_component	autophagosome
H	0005829	cellular_component	cytosol
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0008285	biological_process	negative regulation of cell population proliferation
H	0016491	molecular_function	oxidoreductase activity
H	0031410	cellular_component	cytoplasmic vesicle
H	0042802	molecular_function	identical protein binding
H	0044754	cellular_component	autolysosome
H	0046872	molecular_function	metal ion binding
H	0048147	biological_process	negative regulation of fibroblast proliferation
H	0070062	cellular_component	extracellular exosome
H	0070288	cellular_component	ferritin complex
H	0110076	biological_process	negative regulation of ferroptosis
H	0140315	molecular_function	iron ion sequestering activity
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0004322	molecular_function	ferroxidase activity
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005776	cellular_component	autophagosome
I	0005829	cellular_component	cytosol
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006955	biological_process	immune response
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0008285	biological_process	negative regulation of cell population proliferation
I	0016491	molecular_function	oxidoreductase activity
I	0031410	cellular_component	cytoplasmic vesicle
I	0042802	molecular_function	identical protein binding
I	0044754	cellular_component	autolysosome
I	0046872	molecular_function	metal ion binding
I	0048147	biological_process	negative regulation of fibroblast proliferation
I	0070062	cellular_component	extracellular exosome
I	0070288	cellular_component	ferritin complex
I	0110076	biological_process	negative regulation of ferroptosis
I	0140315	molecular_function	iron ion sequestering activity
I	1904724	cellular_component	tertiary granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0004322	molecular_function	ferroxidase activity
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005776	cellular_component	autophagosome
J	0005829	cellular_component	cytosol
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0008285	biological_process	negative regulation of cell population proliferation
J	0016491	molecular_function	oxidoreductase activity
J	0031410	cellular_component	cytoplasmic vesicle
J	0042802	molecular_function	identical protein binding
J	0044754	cellular_component	autolysosome
J	0046872	molecular_function	metal ion binding
J	0048147	biological_process	negative regulation of fibroblast proliferation
J	0070062	cellular_component	extracellular exosome
J	0070288	cellular_component	ferritin complex
J	0110076	biological_process	negative regulation of ferroptosis
J	0140315	molecular_function	iron ion sequestering activity
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0004322	molecular_function	ferroxidase activity
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005776	cellular_component	autophagosome
K	0005829	cellular_component	cytosol
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0008285	biological_process	negative regulation of cell population proliferation
K	0016491	molecular_function	oxidoreductase activity
K	0031410	cellular_component	cytoplasmic vesicle
K	0042802	molecular_function	identical protein binding
K	0044754	cellular_component	autolysosome
K	0046872	molecular_function	metal ion binding
K	0048147	biological_process	negative regulation of fibroblast proliferation
K	0070062	cellular_component	extracellular exosome
K	0070288	cellular_component	ferritin complex
K	0110076	biological_process	negative regulation of ferroptosis
K	0140315	molecular_function	iron ion sequestering activity
K	1904724	cellular_component	tertiary granule lumen
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0004322	molecular_function	ferroxidase activity
L	0005506	molecular_function	iron ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005776	cellular_component	autophagosome
L	0005829	cellular_component	cytosol
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0008285	biological_process	negative regulation of cell population proliferation
L	0016491	molecular_function	oxidoreductase activity
L	0031410	cellular_component	cytoplasmic vesicle
L	0042802	molecular_function	identical protein binding
L	0044754	cellular_component	autolysosome
L	0046872	molecular_function	metal ion binding
L	0048147	biological_process	negative regulation of fibroblast proliferation
L	0070062	cellular_component	extracellular exosome
L	0070288	cellular_component	ferritin complex
L	0110076	biological_process	negative regulation of ferroptosis
L	0140315	molecular_function	iron ion sequestering activity
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 201

Chain	Residue
A	ARG9
A	ASN11
A	TYR12
A	HOH515

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 202

Chain	Residue
A	GLN14
A	HOH481

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 203

Chain	Residue
A	ASP91
A	ASP92

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG A 204

Chain	Residue
A	GLU62
A	HIS65
A	HOH314
A	HOH320
A	GLU27

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 205

Chain	Residue
A	GLN58
A	GLU61
A	HOH312
A	HOH366
A	HOH440
A	HOH457

---

site_id	AC6
Number of Residues	9
Details	binding site for residue MG A 206

Chain	Residue
A	ASP131
A	HOH303
A	HOH331
B	ASP131
B	HOH309
B	HOH328
C	ASP131
C	HOH304
C	HOH347

---

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 207

Chain	Residue
A	SER31
A	ARG63
H	SER31
H	ARG63

---

site_id	AC8
Number of Residues	3
Details	binding site for residue OXY A 208

Chain	Residue
A	HIS105
A	LEU106
A	ASN109

---

site_id	AC9
Number of Residues	2
Details	binding site for residue CL B 201

Chain	Residue
B	ASP91
B	ASP92

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CL B 202

Chain	Residue
B	GLN83
B	ASP84
E	LYS86
E	HOH524

---

site_id	AD2
Number of Residues	4
Details	binding site for residue CL B 203

Chain	Residue
B	ARG9
B	ASN11
B	TYR12
B	HOH522

---

site_id	AD3
Number of Residues	4
Details	binding site for residue CL B 204

Chain	Residue
B	HIS173
E	HIS173
F	HIS173
J	HIS173

---

site_id	AD4
Number of Residues	5
Details	binding site for residue MG B 205

Chain	Residue
B	GLU27
B	GLU62
B	HIS65
B	HOH313
B	HOH319

---

site_id	AD5
Number of Residues	6
Details	binding site for residue MG B 206

Chain	Residue
B	GLN58
B	GLU61
B	HOH306
B	HOH402
B	HOH429
B	HOH438

---

site_id	AD6
Number of Residues	4
Details	binding site for residue GOL B 207

Chain	Residue
B	SER31
B	ARG63
G	SER31
G	ARG63

---

site_id	AD7
Number of Residues	5
Details	binding site for residue OXY B 208

Chain	Residue
B	SER163
B	GLY164
B	LEU165
B	HOH466
J	LYS157

---

site_id	AD8
Number of Residues	2
Details	binding site for residue CL C 201

Chain	Residue
C	ASP91
C	ASP92

---

site_id	AD9
Number of Residues	5
Details	binding site for residue CL C 202

Chain	Residue
C	ARG9
C	ASN11
C	TYR12
C	HOH513
C	HOH529

---

site_id	AE1
Number of Residues	4
Details	binding site for residue CL C 203

Chain	Residue
C	HIS173
C	HIS173
H	HIS173
H	HIS173

---

site_id	AE2
Number of Residues	5
Details	binding site for residue MG C 204

Chain	Residue
C	GLU27
C	GLU62
C	HIS65
C	HOH315
C	HOH321

---

site_id	AE3
Number of Residues	6
Details	binding site for residue MG C 205

Chain	Residue
C	GLN58
C	GLU61
C	HOH309
C	HOH316
C	HOH400
C	HOH412

---

site_id	AE4
Number of Residues	4
Details	binding site for residue GOL C 206

Chain	Residue
C	ARG63
C	HOH306
F	SER31
F	ARG63

---

site_id	AE5
Number of Residues	2
Details	binding site for residue OXY C 207

Chain	Residue
C	GLN14
C	HOH327

---

site_id	AE6
Number of Residues	3
Details	binding site for residue OXY C 208

Chain	Residue
C	HOH394
C	ARG79
C	HOH342

---

site_id	AE7
Number of Residues	5
Details	binding site for residue OXY C 209

Chain	Residue
C	THR122
C	ASN125
C	HOH312
C	HOH428
C	HOH477

---

site_id	AE8
Number of Residues	4
Details	binding site for residue CL D 201

Chain	Residue
D	ARG9
D	ASN11
D	TYR12
D	HOH516

---

site_id	AE9
Number of Residues	2
Details	binding site for residue CL D 202

Chain	Residue
D	ASN11
D	HOH570

---

site_id	AF1
Number of Residues	2
Details	binding site for residue CL D 203

Chain	Residue
D	GLN14
D	HOH483

---

site_id	AF2
Number of Residues	2
Details	binding site for residue CL D 204

Chain	Residue
D	ASP91
D	ASP92

---

site_id	AF3
Number of Residues	4
Details	binding site for residue CL D 205

Chain	Residue
A	GLN83
A	ASP84
D	LYS86
D	HOH542

---

site_id	AF4
Number of Residues	4
Details	binding site for residue CL D 206

Chain	Residue
A	HIS173
D	HIS173
G	HIS173
K	HIS173

---

site_id	AF5
Number of Residues	6
Details	binding site for residue MG D 207

Chain	Residue
D	GLU27
D	GLU62
D	HIS65
D	HOH310
D	HOH315
D	HOH324

---

site_id	AF6
Number of Residues	6
Details	binding site for residue MG D 208

Chain	Residue
D	GLN58
D	GLU61
D	HOH311
D	HOH377
D	HOH450
D	HOH455

---

site_id	AF7
Number of Residues	9
Details	binding site for residue FE D 209

Chain	Residue
D	ASP131
D	HOH303
D	HOH340
E	ASP131
E	HOH305
E	HOH327
I	ASP131
I	HOH303
I	HOH357

---

site_id	AF8
Number of Residues	4
Details	binding site for residue GOL D 210

Chain	Residue
D	SER31
D	ARG63
L	SER31
L	ARG63

---

site_id	AF9
Number of Residues	4
Details	binding site for residue OXY D 211

Chain	Residue
D	SER163
D	GLY164
D	LEU165
G	LYS157

---

site_id	AG1
Number of Residues	5
Details	binding site for residue CL E 201

Chain	Residue
E	ARG43
E	HOH390
E	HOH570
K	HOH439
K	HOH581

---

site_id	AG2
Number of Residues	2
Details	binding site for residue CL E 202

Chain	Residue
E	ASP91
E	ASP92

---

site_id	AG3
Number of Residues	4
Details	binding site for residue CL E 203

Chain	Residue
B	LYS86
B	HOH532
E	GLN83
E	ASP84

---

site_id	AG4
Number of Residues	5
Details	binding site for residue MG E 204

Chain	Residue
E	GLU27
E	GLU62
E	HIS65
E	HOH313
E	HOH318

---

site_id	AG5
Number of Residues	6
Details	binding site for residue MG E 205

Chain	Residue
E	GLN58
E	GLU61
E	HOH310
E	HOH398
E	HOH434
E	HOH441

---

site_id	AG6
Number of Residues	4
Details	binding site for residue GOL E 206

Chain	Residue
E	SER31
E	ARG63
K	SER31
K	ARG63

---

site_id	AG7
Number of Residues	6
Details	binding site for residue OXY E 207

Chain	Residue
E	SER163
E	GLY164
E	LEU165
E	HOH439
F	LYS157
F	MET158

---

site_id	AG8
Number of Residues	3
Details	binding site for residue OXY E 208

Chain	Residue
E	ARG79
E	HOH359
E	HOH435

---

site_id	AG9
Number of Residues	2
Details	binding site for residue CL F 201

Chain	Residue
F	ASP91
F	ASP92

---

site_id	AH1
Number of Residues	2
Details	binding site for residue CL F 202

Chain	Residue
F	HOH457
F	HOH544

---

site_id	AH2
Number of Residues	2
Details	binding site for residue CL F 203

Chain	Residue
F	GLU94
F	HOH376

---

site_id	AH3
Number of Residues	5
Details	binding site for residue CL F 204

Chain	Residue
F	ARG9
F	ASN11
F	TYR12
F	HOH512
F	HOH523

---

site_id	AH4
Number of Residues	2
Details	binding site for residue CL F 205

Chain	Residue
F	GLN14
F	HOH476

---

site_id	AH5
Number of Residues	5
Details	binding site for residue MG F 206

Chain	Residue
F	GLU27
F	GLU62
F	HIS65
F	HOH317
F	HOH324

---

site_id	AH6
Number of Residues	6
Details	binding site for residue MG F 207

Chain	Residue
F	GLN58
F	GLU61
F	HOH310
F	HOH388
F	HOH424
F	HOH472

---

site_id	AH7
Number of Residues	3
Details	binding site for residue OXY F 208

Chain	Residue
F	HIS105
F	LEU106
F	ASN109

---

site_id	AH8
Number of Residues	5
Details	binding site for residue CL G 201

Chain	Residue
G	ARG9
G	ASN11
G	TYR12
G	HOH517
G	HOH530

---

site_id	AH9
Number of Residues	3
Details	binding site for residue CL G 202

Chain	Residue
G	GLN14
G	HOH478
G	HOH556

---

site_id	AI1
Number of Residues	2
Details	binding site for residue CL G 203

Chain	Residue
G	ASP91
G	ASP92

---

site_id	AI2
Number of Residues	4
Details	binding site for residue CL G 204

Chain	Residue
G	GLN83
G	ASP84
K	LYS86
K	HOH544

---

site_id	AI3
Number of Residues	5
Details	binding site for residue MG G 205

Chain	Residue
G	GLU27
G	GLU62
G	HIS65
G	HOH316
G	HOH321

---

site_id	AI4
Number of Residues	9
Details	binding site for residue MG G 206

Chain	Residue
G	ASP131
G	HOH304
G	HOH330
J	ASP131
J	HOH303
L	ASP131
L	HOH304
L	HOH328
L	HOH340

---

site_id	AI5
Number of Residues	5
Details	binding site for residue MG G 207

Chain	Residue
G	GLN58
G	GLU61
G	HOH314
G	HOH406
G	HOH408

---

site_id	AI6
Number of Residues	4
Details	binding site for residue OXY G 208

Chain	Residue
A	LYS157
G	SER163
G	GLY164
G	LEU165

---

site_id	AI7
Number of Residues	4
Details	binding site for residue OXY G 209

Chain	Residue
G	HIS105
G	LEU106
G	ASN109
G	HOH437

---

site_id	AI8
Number of Residues	5
Details	binding site for residue CL H 201

Chain	Residue
H	ARG9
H	ASN11
H	TYR12
H	HOH511
H	HOH524

---

site_id	AI9
Number of Residues	1
Details	binding site for residue CL H 202

Chain	Residue
H	ASN11

---

site_id	AJ1
Number of Residues	2
Details	binding site for residue CL H 203

Chain	Residue
H	ASP91
H	ASP92

---

site_id	AJ2
Number of Residues	6
Details	binding site for residue MG H 204

Chain	Residue
H	GLU27
H	GLU62
H	HIS65
H	HOH310
H	HOH312
H	HOH317

---

site_id	AJ3
Number of Residues	9
Details	binding site for residue MG H 205

Chain	Residue
F	ASP131
F	HOH303
F	HOH348
H	ASP131
H	HOH303
H	HOH330
K	ASP131
K	HOH302
K	HOH333

---

site_id	AJ4
Number of Residues	3
Details	binding site for residue MG H 206

Chain	Residue
H	ASN125
H	HOH425
K	LYS119

---

site_id	AJ5
Number of Residues	6
Details	binding site for residue MG H 207

Chain	Residue
H	GLN58
H	GLU61
H	HOH308
H	HOH393
H	HOH405
H	HOH421

---

site_id	AJ6
Number of Residues	4
Details	binding site for residue OXY H 208

Chain	Residue
H	SER4
H	ARG79
H	HOH339
H	HOH441

---

site_id	AJ7
Number of Residues	2
Details	binding site for residue CL I 201

Chain	Residue
I	GLN14
I	HOH490

---

site_id	AJ8
Number of Residues	5
Details	binding site for residue CL I 202

Chain	Residue
I	ARG9
I	ASN11
I	TYR12
I	HOH514
I	HOH524

---

site_id	AJ9
Number of Residues	4
Details	binding site for residue CL I 203

Chain	Residue
I	HIS173
I	HIS173
L	HIS173
L	HIS173

---

site_id	AK1
Number of Residues	2
Details	binding site for residue CL I 204

Chain	Residue
I	ASP91
I	ASP92

---

site_id	AK2
Number of Residues	3
Details	binding site for residue CL I 205

Chain	Residue
I	GLU94
I	SER95
I	HOH534

---

site_id	AK3
Number of Residues	3
Details	binding site for residue CL I 206

Chain	Residue
I	GLN83
I	ASP84
I	HOH547

---

site_id	AK4
Number of Residues	6
Details	binding site for residue MG I 207

Chain	Residue
I	HOH325
I	HOH347
I	HOH547
J	HOH367
J	HOH539
J	HOH576

---

site_id	AK5
Number of Residues	5
Details	binding site for residue MG I 208

Chain	Residue
I	GLU27
I	GLU62
I	HIS65
I	HOH313
I	HOH319

---

site_id	AK6
Number of Residues	6
Details	binding site for residue MG I 209

Chain	Residue
I	GLN58
I	GLU61
I	HOH315
I	HOH391
I	HOH399
I	HOH420

---

site_id	AK7
Number of Residues	3
Details	binding site for residue GOL I 210

Chain	Residue
I	ARG63
J	SER31
J	ARG63

---

site_id	AK8
Number of Residues	4
Details	binding site for residue OXY I 211

Chain	Residue
I	THR122
I	ASN125
I	HOH385
I	HOH418

---

site_id	AK9
Number of Residues	3
Details	binding site for residue OXY I 212

Chain	Residue
I	HIS105
I	LEU106
I	ASN109

---

site_id	AL1
Number of Residues	2
Details	binding site for residue CL J 201

Chain	Residue
J	ASP91
J	ASP92

---

site_id	AL2
Number of Residues	5
Details	binding site for residue CL J 202

Chain	Residue
J	ARG9
J	ASN11
J	TYR12
J	HOH518
J	HOH525

---

site_id	AL3
Number of Residues	2
Details	binding site for residue CL J 203

Chain	Residue
J	GLN14
J	HOH481

---

site_id	AL4
Number of Residues	5
Details	binding site for residue MG J 204

Chain	Residue
J	GLU27
J	GLU62
J	HIS65
J	HOH318
J	HOH322

---

site_id	AL5
Number of Residues	6
Details	binding site for residue MG J 205

Chain	Residue
J	GLN58
J	GLU61
J	HOH311
J	HOH373
J	HOH429
J	HOH468

---

site_id	AL6
Number of Residues	5
Details	binding site for residue CL K 201

Chain	Residue
K	ARG9
K	ASN11
K	TYR12
K	HOH519
K	HOH529

---

site_id	AL7
Number of Residues	3
Details	binding site for residue CL K 202

Chain	Residue
K	GLN14
K	HOH480
K	HOH558

---

site_id	AL8
Number of Residues	2
Details	binding site for residue CL K 203

Chain	Residue
K	ASP91
K	ASP92

---

site_id	AL9
Number of Residues	5
Details	binding site for residue MG K 204

Chain	Residue
K	GLU27
K	GLU62
K	HIS65
K	HOH316
K	HOH319

---

site_id	AM1
Number of Residues	5
Details	binding site for residue MG K 205

Chain	Residue
K	GLN58
K	GLU61
K	HOH311
K	HOH399
K	HOH412

---

site_id	AM2
Number of Residues	2
Details	binding site for residue CL L 201

Chain	Residue
L	ASP91
L	ASP92

---

site_id	AM3
Number of Residues	4
Details	binding site for residue CL L 202

Chain	Residue
L	ARG9
L	ASN11
L	TYR12
L	HOH507

---

site_id	AM4
Number of Residues	6
Details	binding site for residue MG L 203

Chain	Residue
L	GLU27
L	GLU62
L	HIS65
L	HOH312
L	HOH313
L	HOH320

---

site_id	AM5
Number of Residues	6
Details	binding site for residue MG L 204

Chain	Residue
L	GLN58
L	GLU61
L	HOH308
L	HOH310
L	HOH375
L	HOH418

---

site_id	AM6
Number of Residues	4
Details	binding site for residue OXY L 205

Chain	Residue
L	HIS105
L	LEU106
L	ASN109
L	HOH440

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLSDFIEthYLneqvkaIK

Chain	Residue	Details
A	ASP126-LYS146

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1788
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1992356","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FHA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Site: {"description":"Essential for association with cargo receptor NCOA4","evidences":[{"source":"PubMed","id":"26436293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---