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7CJ2

Crystal structure of the Fab antibody complexed with human YKL-40

Functional Information from GO Data
ChainGOidnamespacecontents
A0004568molecular_functionchitinase activity
A0005201molecular_functionextracellular matrix structural constituent
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005975biological_processcarbohydrate metabolic process
A0006032biological_processchitin catabolic process
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0007250biological_processactivation of NF-kappaB-inducing kinase activity
A0008061molecular_functionchitin binding
A0009612biological_processresponse to mechanical stimulus
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0030246molecular_functioncarbohydrate binding
A0030324biological_processlung development
A0031012cellular_componentextracellular matrix
A0032757biological_processpositive regulation of interleukin-8 production
A0034612biological_processresponse to tumor necrosis factor
A0035580cellular_componentspecific granule lumen
A0045766biological_processpositive regulation of angiogenesis
A0048471cellular_componentperinuclear region of cytoplasm
A0051216biological_processcartilage development
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070555biological_processresponse to interleukin-1
A0070741biological_processresponse to interleukin-6
A0071356biological_processcellular response to tumor necrosis factor
B0004568molecular_functionchitinase activity
B0005201molecular_functionextracellular matrix structural constituent
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005975biological_processcarbohydrate metabolic process
B0006032biological_processchitin catabolic process
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0007250biological_processactivation of NF-kappaB-inducing kinase activity
B0008061molecular_functionchitin binding
B0009612biological_processresponse to mechanical stimulus
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0030246molecular_functioncarbohydrate binding
B0030324biological_processlung development
B0031012cellular_componentextracellular matrix
B0032757biological_processpositive regulation of interleukin-8 production
B0034612biological_processresponse to tumor necrosis factor
B0035580cellular_componentspecific granule lumen
B0045766biological_processpositive regulation of angiogenesis
B0048471cellular_componentperinuclear region of cytoplasm
B0051216biological_processcartilage development
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0070062cellular_componentextracellular exosome
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070555biological_processresponse to interleukin-1
B0070741biological_processresponse to interleukin-6
B0071356biological_processcellular response to tumor necrosis factor
Functional Information from PROSITE/UniProt
site_idPS00217
Number of Residues26
DetailsSUGAR_TRANSPORT_2 Sugar transport proteins signature 2. FhGAWrGTtghhsplFrgQedaspdR
ChainResidueDetails
APHE187-ARG212

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
DTYR193-HIS199
CTYR197-HIS203

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01258
ChainResidueDetails
AGLU49
BTRP331
AGLY76
ATYR120
AMET183
ATRP331
BGLU49
BGLY76
BTYR120
BMET183

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING:
ChainResidueDetails
AARG242
BARG242

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12775711
ChainResidueDetails
AASN39
BASN39

222415

PDB entries from 2024-07-10

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