Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue D8F A 401 |
| Chain | Residue |
| A | TYR38 |
| A | HOH548 |
| A | HOH762 |
| A | GLY89 |
| A | GLY90 |
| A | GLY91 |
| A | SER162 |
| A | ALA163 |
| A | LEU212 |
| A | HIS284 |
| A | HOH519 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 402 |
| Chain | Residue |
| A | GLU76 |
| A | SER77 |
| A | HOH694 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | PRO68 |
| A | ASP119 |
| A | TYR120 |
| A | HOH510 |
| A | HOH513 |
| A | HOH595 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | GLU136 |
| A | ARG232 |
| A | HOH503 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ASP196 |
| A | ALA197 |
| A | ASP221 |
| A | ARG228 |
| A | HOH511 |
| A | HOH626 |
| A | HOH667 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 406 |
| Chain | Residue |
| A | ALA205 |
| A | ARG257 |
| A | DMS407 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 407 |
| Chain | Residue |
| A | ARG257 |
| A | ARG261 |
| A | DMS406 |
| B | HOH735 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | PHE14 |
| A | ALA292 |
| A | HOH550 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | ARG140 |
| A | ALA180 |
| A | HOH635 |
| A | HOH668 |
| A | HOH697 |
| C | HOH887 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | HIS42 |
| A | GLY43 |
| A | ASP98 |
| A | THR99 |
| A | HIS101 |
| A | ASN102 |
| A | HOH540 |
| A | HOH587 |
| A | HOH643 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | ILE55 |
| A | ASN57 |
| A | HIS101 |
| A | HOH699 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 412 |
| Chain | Residue |
| A | ALA22 |
| A | GLY23 |
| A | PRO24 |
| A | MET29 |
| A | HOH618 |
| C | VAL39 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 413 |
| Chain | Residue |
| A | LYS12 |
| A | GLY209 |
| A | HOH734 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | LEU193 |
| B | ASP196 |
| B | ALA197 |
| B | VAL198 |
| B | ILE217 |
| B | ARG228 |
| B | HOH683 |
| B | HOH687 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue D8F B 502 |
| Chain | Residue |
| B | TYR38 |
| B | GLY90 |
| B | GLY91 |
| B | SER162 |
| B | ALA163 |
| B | LEU212 |
| B | PHE220 |
| B | HIS284 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | ASP96 |
| B | LEU97 |
| B | ASP98 |
| B | ASP119 |
| B | HOH677 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 504 |
| Chain | Residue |
| A | HOH640 |
| B | ARG257 |
| B | ARG261 |
| B | EDO509 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | THR152 |
| B | HOH610 |
| B | HOH810 |
| D | THR152 |
| D | HOH613 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue DIO B 506 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 507 |
| Chain | Residue |
| B | ASP119 |
| B | TYR120 |
| B | HOH613 |
| B | HOH708 |
| B | HOH767 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | GLY312 |
| B | HOH654 |
| B | HOH748 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | ARG257 |
| B | DMS504 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | GLN173 |
| B | PRO231 |
| B | HOH661 |
| B | HOH691 |
| B | HOH728 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | ILE55 |
| B | ARG56 |
| D | GLU76 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 512 |
| Chain | Residue |
| B | ILE7 |
| B | LEU15 |
| B | GLY209 |
| B | PHE210 |
| B | HOH784 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue NPO B 513 |
| Chain | Residue |
| B | PHE14 |
| B | MET21 |
| B | MET44 |
| B | NPO514 |
| B | HOH602 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue NPO B 514 |
| Chain | Residue |
| B | PHE14 |
| B | MET21 |
| B | NPO513 |
| B | HOH602 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 515 |
| Chain | Residue |
| B | PRO9 |
| B | ASP10 |
| B | SER295 |
| B | HOH653 |
| B | HOH704 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 516 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 517 |
| Chain | Residue |
| B | ARG75 |
| B | GLU76 |
| B | SER77 |
| B | HOH624 |
| B | HOH647 |
| B | HOH703 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue DMS C 501 |
| Chain | Residue |
| C | GLU76 |
| C | SER77 |
| C | HOH610 |
| site_id | AF5 |
| Number of Residues | 12 |
| Details | binding site for residue D8F C 502 |
| Chain | Residue |
| C | TYR38 |
| C | GLY90 |
| C | GLY91 |
| C | SER162 |
| C | ALA163 |
| C | LEU193 |
| C | LEU212 |
| C | PHE220 |
| C | HIS284 |
| C | HOH642 |
| C | HOH755 |
| C | HOH803 |
| site_id | AF6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | ARG257 |
| C | ARG261 |
| C | EDO509 |
| C | HOH702 |
| C | HOH812 |
| D | GLU269 |
| D | HOH659 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| A | HOH502 |
| C | GLU136 |
| C | ARG232 |
| C | HOH619 |
| C | HOH679 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 505 |
| Chain | Residue |
| C | ARG70 |
| C | ASP96 |
| C | LEU97 |
| C | ASP98 |
| C | ASP119 |
| site_id | AF9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 506 |
| Chain | Residue |
| C | PRO68 |
| C | ASP119 |
| C | TYR120 |
| C | HOH601 |
| C | HOH608 |
| C | HOH639 |
| C | HOH685 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 507 |
| Chain | Residue |
| C | ARG140 |
| C | PRO179 |
| C | ALA180 |
| C | HOH633 |
| site_id | AG2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 508 |
| Chain | Residue |
| C | PRO24 |
| C | HOH703 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 509 |
| Chain | Residue |
| C | ARG257 |
| C | GOL503 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue DMS C 510 |
| Chain | Residue |
| C | ASN57 |
| C | ARG70 |
| C | HIS101 |
| C | HOH895 |
| site_id | AG5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL C 511 |
| Chain | Residue |
| C | LEU193 |
| C | ASP196 |
| C | ALA197 |
| C | VAL198 |
| C | ILE217 |
| C | ASP221 |
| C | ARG228 |
| C | HOH612 |
| C | HOH738 |
| C | HOH755 |
| site_id | AG6 |
| Number of Residues | 8 |
| Details | binding site for residue D8F D 501 |
| Chain | Residue |
| D | TYR38 |
| D | GLY90 |
| D | GLY91 |
| D | SER162 |
| D | ALA163 |
| D | LEU212 |
| D | HIS284 |
| D | HOH657 |
| site_id | AG7 |
| Number of Residues | 10 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| D | LEU193 |
| D | ASP196 |
| D | ALA197 |
| D | VAL198 |
| D | ILE217 |
| D | ASP221 |
| D | ARG228 |
| D | PHE234 |
| D | HOH686 |
| D | HOH704 |
| site_id | AG8 |
| Number of Residues | 1 |
| Details | binding site for residue DIO D 503 |
| site_id | AG9 |
| Number of Residues | 2 |
| Details | binding site for residue DIO D 504 |
| Chain | Residue |
| D | LEU15 |
| D | GLY209 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue DMS D 505 |
| Chain | Residue |
| D | ARG75 |
| D | GLU76 |
| D | SER77 |
| D | HOH712 |
| D | HOH737 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 506 |
| Chain | Residue |
| D | ARG140 |
| D | ALA180 |
| D | HOH665 |
| D | HOH672 |
| site_id | AH3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 507 |
| Chain | Residue |
| D | ASP119 |
| D | TYR120 |
| site_id | AH4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 508 |
| Chain | Residue |
| B | HOH610 |
| B | HOH755 |
| D | PRO146 |
| D | SER147 |
| D | HOH601 |
| site_id | AH5 |
| Number of Residues | 3 |
| Details | binding site for residue DIO D 509 |
| Chain | Residue |
| D | PHE14 |
| D | ALA292 |
| D | ALA292 |
| site_id | AH6 |
| Number of Residues | 5 |
| Details | binding site for residue DMS D 510 |
| Chain | Residue |
| C | HOH635 |
| D | ARG257 |
| D | ARG261 |
| D | DMS511 |
| D | HOH776 |
| site_id | AH7 |
| Number of Residues | 2 |
| Details | binding site for residue DMS D 511 |
| Chain | Residue |
| D | ARG257 |
| D | DMS510 |
| site_id | AH8 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 D 512 |
| Chain | Residue |
| B | SER145 |
| B | PRO146 |
| B | SER147 |
| B | GLY150 |
| B | ARG151 |
| B | THR152 |
| D | SER145 |
| D | SER147 |
| D | GLY150 |
| D | ARG151 |
| D | THR152 |
