7CHA
Cryo-EM structure of P.aeruginosa MlaFEBD with AMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005548 | molecular_function | phospholipid transporter activity |
| A | 0015914 | biological_process | phospholipid transport |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005548 | molecular_function | phospholipid transporter activity |
| B | 0015914 | biological_process | phospholipid transport |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005548 | molecular_function | phospholipid transporter activity |
| C | 0015914 | biological_process | phospholipid transport |
| D | 0005543 | molecular_function | phospholipid binding |
| D | 0005548 | molecular_function | phospholipid transporter activity |
| D | 0015914 | biological_process | phospholipid transport |
| E | 0005543 | molecular_function | phospholipid binding |
| E | 0005548 | molecular_function | phospholipid transporter activity |
| E | 0015914 | biological_process | phospholipid transport |
| F | 0005543 | molecular_function | phospholipid binding |
| F | 0005548 | molecular_function | phospholipid transporter activity |
| F | 0015914 | biological_process | phospholipid transport |
| G | 0005548 | molecular_function | phospholipid transporter activity |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0015914 | biological_process | phospholipid transport |
| G | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| G | 0080033 | biological_process | response to nitrite |
| H | 0005548 | molecular_function | phospholipid transporter activity |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0015914 | biological_process | phospholipid transport |
| H | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| H | 0080033 | biological_process | response to nitrite |
| I | 0005524 | molecular_function | ATP binding |
| I | 0016887 | molecular_function | ATP hydrolysis activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0016887 | molecular_function | ATP hydrolysis activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue LPP G 301 |
| Chain | Residue |
| C | LEU21 |
| G | LEU68 |
| H | LEU248 |
| H | LPP302 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue LPP G 302 |
| Chain | Residue |
| G | ARG241 |
| G | TYR245 |
| G | ALA249 |
| G | LEU253 |
| G | PHE255 |
| G | LPP303 |
| H | PHE69 |
| H | MET72 |
| H | LPP303 |
| G | ALA23 |
| G | SER27 |
| G | TRP219 |
| G | ILE220 |
| G | GLN224 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue LPP G 303 |
| Chain | Residue |
| G | VAL20 |
| G | VAL21 |
| G | TYR245 |
| G | LPP302 |
| H | LPP303 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue LPP H 302 |
| Chain | Residue |
| A | ILE8 |
| A | GLY11 |
| A | LEU12 |
| A | LEU15 |
| C | LEU14 |
| G | LPP301 |
| H | VAL20 |
| H | VAL21 |
| H | LEU24 |
| H | TYR245 |
| H | LPP301 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue LPP H 303 |
| Chain | Residue |
| G | VAL244 |
| G | LEU248 |
| G | LPP302 |
| G | LPP303 |
| H | LEU58 |
| H | LEU68 |
| H | PHE69 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide LPP G 304 and ILE G 81 |
| Chain | Residue |
| G | GLN77 |
| G | GLY78 |
| G | TYR79 |
| G | ASN80 |
| G | LEU82 |
| G | SER84 |
| G | TYR85 |
| G | SER87 |
| G | ALA90 |
| G | GLN93 |
| G | MET94 |
| G | THR98 |
| G | GLU102 |
| H | LEU74 |
| H | GLN77 |
| H | ILE81 |
| H | LEU82 |
| H | TYR85 |
| H | GLN93 |
| H | MET94 |
| H | LEU97 |
| H | THR98 |
| H | GLU102 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide LPP G 304 and TYR G 85 |
| Chain | Residue |
| G | ILE81 |
| G | LEU82 |
| G | ILE83 |
| G | SER84 |
| G | GLY86 |
| G | SER87 |
| G | ALA90 |
| G | GLN93 |
| G | MET94 |
| G | THR98 |
| G | GLU102 |
| H | LEU74 |
| H | GLN77 |
| H | ILE81 |
| H | LEU82 |
| H | TYR85 |
| H | GLN93 |
| H | MET94 |
| H | THR98 |
| H | GLU102 |
| site_id | AC8 |
| Number of Residues | 33 |
| Details | binding site for Di-peptide LPP G 304 and LEU H 74 |
| Chain | Residue |
| G | LEU99 |
| G | GLU102 |
| H | ILE70 |
| H | GLY71 |
| H | MET72 |
| H | VAL73 |
| H | ALA75 |
| H | LEU76 |
| H | GLN77 |
| H | GLY78 |
| H | ILE81 |
| H | LEU82 |
| H | TYR85 |
| H | GLN93 |
| H | MET94 |
| H | THR98 |
| H | LEU99 |
| H | GLU102 |
| G | ILE70 |
| G | GLY71 |
| G | MET72 |
| G | VAL73 |
| G | ALA75 |
| G | LEU76 |
| G | GLN77 |
| G | GLY78 |
| G | ILE81 |
| G | TYR85 |
| G | SER87 |
| G | ALA90 |
| G | GLN93 |
| G | MET94 |
| G | THR98 |
| site_id | AC9 |
| Number of Residues | 27 |
| Details | binding site for Di-peptide LPP G 304 and ILE H 81 |
| Chain | Residue |
| G | GLN77 |
| G | GLY78 |
| G | TYR79 |
| G | ASN80 |
| G | LEU82 |
| G | SER84 |
| G | TYR85 |
| G | SER87 |
| G | ALA90 |
| G | GLN93 |
| G | MET94 |
| G | LEU97 |
| G | THR98 |
| G | GLU102 |
| H | LEU74 |
| H | GLN77 |
| H | GLY78 |
| H | TYR79 |
| H | ASN80 |
| H | LEU82 |
| H | SER84 |
| H | TYR85 |
| H | GLN93 |
| H | MET94 |
| H | LEU97 |
| H | THR98 |
| H | GLU102 |
| site_id | AD1 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide LPP G 304 and TYR H 85 |
| Chain | Residue |
| G | ILE81 |
| G | LEU82 |
| G | ILE83 |
| G | SER84 |
| G | GLY86 |
| G | SER87 |
| G | ALA90 |
| G | GLN93 |
| G | MET94 |
| G | THR98 |
| G | GLU102 |
| H | LEU74 |
| H | GLN77 |
| H | ILE81 |
| H | LEU82 |
| H | ILE83 |
| H | SER84 |
| H | GLY86 |
| H | SER87 |
| H | GLN93 |
| H | MET94 |
| H | THR98 |
| H | GLU102 |
| site_id | AD2 |
| Number of Residues | 28 |
| Details | binding site for Di-peptide LPP G 304 and GLU H 102 |
| Chain | Residue |
| G | VAL73 |
| G | GLN77 |
| G | ILE81 |
| G | TYR85 |
| G | SER87 |
| G | ALA90 |
| G | GLN93 |
| G | MET94 |
| G | THR98 |
| G | ARG101 |
| G | LEU103 |
| G | GLY104 |
| G | PRO105 |
| G | VAL106 |
| H | VAL73 |
| H | LEU74 |
| H | GLN77 |
| H | ILE81 |
| H | LEU82 |
| H | TYR85 |
| H | GLN93 |
| H | MET94 |
| H | THR98 |
| H | ARG101 |
| H | LEU103 |
| H | GLY104 |
| H | PRO105 |
| H | VAL106 |
| site_id | AD3 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide LPP H 301 and ILE H 220 |
| Chain | Residue |
| A | LEU22 |
| G | PHE69 |
| H | ALA23 |
| H | SER27 |
| H | VAL216 |
| H | VAL217 |
| H | TRP219 |
| H | ALA221 |
| H | VAL222 |
| H | TYR223 |
| H | GLN224 |
| H | ARG241 |
| H | TYR245 |
| H | ALA246 |
| H | ALA249 |
| H | LPP302 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ANP I 301 and GLY I 46 |
| Chain | Residue |
| I | ARG18 |
| I | ARG21 |
| I | ILE23 |
| I | PHE24 |
| I | PRO42 |
| I | SER43 |
| I | GLY44 |
| I | CYS45 |
| I | LYS47 |
| I | THR48 |
| I | THR49 |
| I | LEU50 |
| I | HIS203 |
| site_id | AD5 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide ANP I 301 and LYS I 47 |
| Chain | Residue |
| I | ARG18 |
| I | ARG21 |
| I | ILE23 |
| I | MET40 |
| I | GLY41 |
| I | PRO42 |
| I | SER43 |
| I | GLY44 |
| I | CYS45 |
| I | GLY46 |
| I | THR48 |
| I | THR49 |
| I | LEU50 |
| I | LEU51 |
| I | VAL201 |
| I | HIS203 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide ANP I 301 and ARG I 18 |
| Chain | Residue |
| I | LYS17 |
| I | GLY19 |
| I | SER20 |
| I | ARG21 |
| I | ILE23 |
| I | PRO42 |
| I | SER43 |
| I | GLY44 |
| I | CYS45 |
| I | GLY46 |
| I | LYS47 |
| I | THR48 |
| I | THR49 |
| I | HIS203 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ANP J 301 and GLY J 46 |
| Chain | Residue |
| J | ARG18 |
| J | ARG21 |
| J | ILE23 |
| J | PHE24 |
| J | PRO42 |
| J | SER43 |
| J | GLY44 |
| J | CYS45 |
| J | LYS47 |
| J | THR48 |
| J | THR49 |
| J | LEU50 |
| J | HIS203 |
| site_id | AD8 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide ANP J 301 and LYS J 47 |
| Chain | Residue |
| J | ARG18 |
| J | ARG21 |
| J | ILE23 |
| J | MET40 |
| J | GLY41 |
| J | PRO42 |
| J | SER43 |
| J | GLY44 |
| J | CYS45 |
| J | GLY46 |
| J | THR48 |
| J | THR49 |
| J | LEU50 |
| J | LEU51 |
| J | VAL201 |
| J | HIS203 |
| site_id | AD9 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide ANP J 301 and ARG J 18 |
| Chain | Residue |
| J | LYS17 |
| J | GLY19 |
| J | SER20 |
| J | ARG21 |
| J | ILE23 |
| J | PRO42 |
| J | SER43 |
| J | GLY44 |
| J | CYS45 |
| J | GLY46 |
| J | LYS47 |
| J | THR48 |
| J | THR49 |
| J | HIS203 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGMKRRVALARAI |
| Chain | Residue | Details |
| I | LEU145-ILE159 |
