Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CH3

Crystal structure of Arabinose isomerase from hyper thermophilic bacterium Thermotoga maritima (TMAI) triple mutant (K264A, E265A, K266A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005996	biological_process	monosaccharide metabolic process
A	0008733	molecular_function	L-arabinose isomerase activity
A	0016853	molecular_function	isomerase activity
A	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
A	0019568	biological_process	arabinose catabolic process
A	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005996	biological_process	monosaccharide metabolic process
B	0008733	molecular_function	L-arabinose isomerase activity
B	0016853	molecular_function	isomerase activity
B	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
B	0019568	biological_process	arabinose catabolic process
B	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005996	biological_process	monosaccharide metabolic process
C	0008733	molecular_function	L-arabinose isomerase activity
C	0016853	molecular_function	isomerase activity
C	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
C	0019568	biological_process	arabinose catabolic process
C	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005996	biological_process	monosaccharide metabolic process
D	0008733	molecular_function	L-arabinose isomerase activity
D	0016853	molecular_function	isomerase activity
D	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
D	0019568	biological_process	arabinose catabolic process
D	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005996	biological_process	monosaccharide metabolic process
E	0008733	molecular_function	L-arabinose isomerase activity
E	0016853	molecular_function	isomerase activity
E	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
E	0019568	biological_process	arabinose catabolic process
E	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005996	biological_process	monosaccharide metabolic process
F	0008733	molecular_function	L-arabinose isomerase activity
F	0016853	molecular_function	isomerase activity
F	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
F	0019568	biological_process	arabinose catabolic process
F	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
F	0030145	molecular_function	manganese ion binding
F	0046872	molecular_function	metal ion binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005996	biological_process	monosaccharide metabolic process
G	0008733	molecular_function	L-arabinose isomerase activity
G	0016853	molecular_function	isomerase activity
G	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
G	0019568	biological_process	arabinose catabolic process
G	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
G	0030145	molecular_function	manganese ion binding
G	0046872	molecular_function	metal ion binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005996	biological_process	monosaccharide metabolic process
H	0008733	molecular_function	L-arabinose isomerase activity
H	0016853	molecular_function	isomerase activity
H	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
H	0019568	biological_process	arabinose catabolic process
H	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
H	0030145	molecular_function	manganese ion binding
H	0046872	molecular_function	metal ion binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005996	biological_process	monosaccharide metabolic process
I	0008733	molecular_function	L-arabinose isomerase activity
I	0016853	molecular_function	isomerase activity
I	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
I	0019568	biological_process	arabinose catabolic process
I	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
I	0030145	molecular_function	manganese ion binding
I	0046872	molecular_function	metal ion binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005996	biological_process	monosaccharide metabolic process
J	0008733	molecular_function	L-arabinose isomerase activity
J	0016853	molecular_function	isomerase activity
J	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
J	0019568	biological_process	arabinose catabolic process
J	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
J	0030145	molecular_function	manganese ion binding
J	0046872	molecular_function	metal ion binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005996	biological_process	monosaccharide metabolic process
K	0008733	molecular_function	L-arabinose isomerase activity
K	0016853	molecular_function	isomerase activity
K	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
K	0019568	biological_process	arabinose catabolic process
K	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
K	0030145	molecular_function	manganese ion binding
K	0046872	molecular_function	metal ion binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005996	biological_process	monosaccharide metabolic process
L	0008733	molecular_function	L-arabinose isomerase activity
L	0016853	molecular_function	isomerase activity
L	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
L	0019568	biological_process	arabinose catabolic process
L	0019569	biological_process	L-arabinose catabolic process to xylulose 5-phosphate
L	0030145	molecular_function	manganese ion binding
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MN A 501

Chain	Residue
A	GLU302
A	GLU329
A	HIS346
A	HIS445

site_id	AC2
Number of Residues	2
Details	binding site for residue MN A 502

Chain	Residue
A	GLY395
H	GLY395

site_id	AC3
Number of Residues	4
Details	binding site for residue MN B 501

Chain	Residue
B	HIS445
B	GLU302
B	GLU329
B	HIS346

site_id	AC4
Number of Residues	3
Details	binding site for residue MN C 501

Chain	Residue
C	GLU302
C	GLU329
C	HIS445

site_id	AC5
Number of Residues	5
Details	binding site for residue MN C 502

Chain	Residue
C	ASP194
C	GLY395
D	ASP194
D	GLU197
D	GLY395

site_id	AC6
Number of Residues	3
Details	binding site for residue MN D 501

Chain	Residue
D	GLU302
D	GLU329
D	HIS445

site_id	AC7
Number of Residues	3
Details	binding site for residue MN E 501

Chain	Residue
E	GLU302
E	GLU329
E	HIS445

site_id	AC8
Number of Residues	5
Details	binding site for residue MN E 502

Chain	Residue
E	ASP194
E	GLU197
E	GLY395
I	ASP194
I	GLY395

site_id	AC9
Number of Residues	3
Details	binding site for residue MN F 501

Chain	Residue
F	GLU302
F	GLU329
F	HIS445

site_id	AD1
Number of Residues	6
Details	binding site for residue MN F 502

Chain	Residue
B	ASP194
B	GLU197
B	GLY395
F	ASP194
F	GLU197
F	GLY395

site_id	AD2
Number of Residues	3
Details	binding site for residue MN G 501

Chain	Residue
G	GLU302
G	GLU329
G	HIS445

site_id	AD3
Number of Residues	3
Details	binding site for residue MN H 501

Chain	Residue
H	GLU302
H	GLU329
H	HIS445

site_id	AD4
Number of Residues	4
Details	binding site for residue MN I 501

Chain	Residue
I	GLU302
I	GLU329
I	HIS346
I	HIS445

site_id	AD5
Number of Residues	2
Details	binding site for residue MN J 501

Chain	Residue
J	GLU302
J	GLU329

site_id	AD6
Number of Residues	5
Details	binding site for residue MN J 502

Chain	Residue
J	ASP194
J	GLU197
J	GLY395
K	ASP194
K	GLY395

site_id	AD7
Number of Residues	4
Details	binding site for residue MN K 501

Chain	Residue
K	GLU302
K	GLU329
K	HIS346
K	HIS445

site_id	AD8
Number of Residues	4
Details	binding site for residue MN L 501

Chain	Residue
L	GLU302
L	GLU329
L	HIS346
L	HIS445

site_id	AD9
Number of Residues	4
Details	binding site for residue MN L 502

Chain	Residue
G	ASP194
G	GLY395
L	GLU197
L	GLY395

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00519

Chain	Residue	Details
A	GLU302
C	GLU329
C	HIS346
C	HIS445
D	GLU302
D	GLU329
D	HIS346
D	HIS445
E	GLU302
E	GLU329
E	HIS346
A	GLU329
E	HIS445
F	GLU302
F	GLU329
F	HIS346
F	HIS445
G	GLU302
G	GLU329
G	HIS346
G	HIS445
H	GLU302
A	HIS346
H	GLU329
H	HIS346
H	HIS445
I	GLU302
I	GLU329
I	HIS346
I	HIS445
J	GLU302
J	GLU329
J	HIS346
A	HIS445
J	HIS445
K	GLU302
K	GLU329
K	HIS346
K	HIS445
L	GLU302
L	GLU329
L	HIS346
L	HIS445
B	GLU302
B	GLU329
B	HIS346
B	HIS445
C	GLU302

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)