7CH1
The overall structure of SLC26A9
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006820 | biological_process | monoatomic anion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0009986 | cellular_component | cell surface |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015116 | molecular_function | sulfate transmembrane transporter activity |
| A | 0015701 | biological_process | bicarbonate transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0019531 | molecular_function | oxalate transmembrane transporter activity |
| A | 0019532 | biological_process | oxalate transport |
| A | 0051117 | molecular_function | ATPase binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1902358 | biological_process | sulfate transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006820 | biological_process | monoatomic anion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0009986 | cellular_component | cell surface |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0015106 | molecular_function | bicarbonate transmembrane transporter activity |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015116 | molecular_function | sulfate transmembrane transporter activity |
| B | 0015701 | biological_process | bicarbonate transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0019531 | molecular_function | oxalate transmembrane transporter activity |
| B | 0019532 | biological_process | oxalate transport |
| B | 0051117 | molecular_function | ATPase binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1902358 | biological_process | sulfate transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 801 |
| Chain | Residue |
| A | ASN97 |
| A | ARG169 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 802 |
| Chain | Residue |
| A | THR127 |
| A | PHE128 |
| A | ILE131 |
| A | HIS385 |
| A | VAL386 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 803 |
| Chain | Residue |
| A | THR127 |
| A | GLN85 |
| A | SER107 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 801 |
| Chain | Residue |
| B | ASN97 |
| B | ARG169 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 802 |
| Chain | Residue |
| B | THR127 |
| B | PHE128 |
| B | ILE131 |
| B | HIS385 |
| B | VAL386 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 803 |
| Chain | Residue |
| B | GLN85 |
| B | SER107 |
| B | THR127 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 862 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-TYR70 | |
| B | GLY118-PHE128 | |
| B | GLN191-SER202 | |
| B | ALA274-ARG281 | |
| B | LEU349-ASN366 | |
| B | GLY401-SER404 | |
| B | ASP451-CYS464 | |
| B | VAL490-LEU791 | |
| A | GLY118-PHE128 | |
| A | GLN191-SER202 | |
| A | ALA274-ARG281 | |
| A | LEU349-ASN366 | |
| A | GLY401-SER404 | |
| A | ASP451-CYS464 | |
| A | VAL490-LEU791 | |
| B | MET1-TYR70 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 446 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1 |
| Chain | Residue | Details |
| A | ILE71-ALA96 | |
| A | GLN405-GLY423 | |
| A | LEU429-THR450 | |
| A | ILE465-LEU476 | |
| A | LEU478-SER489 | |
| B | ILE71-ALA96 | |
| B | ALA100-LEU117 | |
| B | ALA129-LEU142 | |
| B | VAL172-MET190 | |
| B | PHE203-PHE224 | |
| B | SER255-ASN273 | |
| A | ALA100-LEU117 | |
| B | PHE282-ILE297 | |
| B | SER328-ASN348 | |
| B | GLN367-PHE382 | |
| B | GLN405-GLY423 | |
| B | LEU429-THR450 | |
| B | ILE465-LEU476 | |
| B | LEU478-SER489 | |
| A | ALA129-LEU142 | |
| A | VAL172-MET190 | |
| A | PHE203-PHE224 | |
| A | SER255-ASN273 | |
| A | PHE282-ILE297 | |
| A | SER328-ASN348 | |
| A | GLN367-PHE382 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 180 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | ASN97-PRO99 | |
| B | ALA143-HIS171 | |
| B | GLY225-GLY235 | |
| B | CYS245-ALA254 | |
| B | SER298-VAL327 | |
| B | LYS383-ALA390 | |
| B | ILE424-PRO428 | |
| B | SER477 | |
| A | ALA143-HIS171 | |
| A | GLY225-GLY235 | |
| A | CYS245-ALA254 | |
| A | SER298-VAL327 | |
| A | LYS383-ALA390 | |
| A | ILE424-PRO428 | |
| A | SER477 | |
| B | ASN97-PRO99 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | INTRAMEM: Helical => ECO:0000250|UniProtKB:Q8BU91 |
| Chain | Residue | Details |
| A | SER236-ILE244 | |
| B | SER236-ILE244 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q8BU91 |
| Chain | Residue | Details |
| A | LEU391-ALA400 | |
| B | LEU391-ALA400 |
