7CGP

Cryo-EM structure of the human mitochondrial translocase TIM22 complex at 3.7 angstrom.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0008320	molecular_function	transmembrane protein transporter activity
A	0030943	molecular_function	mitochondrion targeting sequence binding
A	0032977	molecular_function	membrane insertase activity
A	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
A	0045039	biological_process	protein insertion into mitochondrial inner membrane
A	0071806	biological_process	protein transmembrane transport
A	0090150	biological_process	establishment of protein localization to membrane
B	0001727	molecular_function	lipid kinase activity
B	0001729	molecular_function	ceramide kinase activity
B	0004143	molecular_function	ATP-dependent diacylglycerol kinase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0031966	cellular_component	mitochondrial membrane
B	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
B	0045039	biological_process	protein insertion into mitochondrial inner membrane
B	0046486	biological_process	glycerolipid metabolic process
B	0046512	biological_process	sphingosine biosynthetic process
B	0046513	biological_process	ceramide biosynthetic process
B	0047620	molecular_function	acylglycerol kinase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
C	0045039	biological_process	protein insertion into mitochondrial inner membrane
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0008270	molecular_function	zinc ion binding
D	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
D	0042803	molecular_function	protein homodimerization activity
D	0045039	biological_process	protein insertion into mitochondrial inner membrane
D	0051087	molecular_function	protein-folding chaperone binding
D	0140309	molecular_function	unfolded protein holdase activity
D	0140318	molecular_function	protein transporter activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0008270	molecular_function	zinc ion binding
E	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
E	0042803	molecular_function	protein homodimerization activity
E	0045039	biological_process	protein insertion into mitochondrial inner membrane
E	0051087	molecular_function	protein-folding chaperone binding
E	0140309	molecular_function	unfolded protein holdase activity
E	0140318	molecular_function	protein transporter activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0008270	molecular_function	zinc ion binding
F	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
F	0042803	molecular_function	protein homodimerization activity
F	0045039	biological_process	protein insertion into mitochondrial inner membrane
F	0051087	molecular_function	protein-folding chaperone binding
F	0140309	molecular_function	unfolded protein holdase activity
F	0140318	molecular_function	protein transporter activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
G	0005758	cellular_component	mitochondrial intermembrane space
G	0008270	molecular_function	zinc ion binding
G	0032977	molecular_function	membrane insertase activity
G	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
G	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
G	0042803	molecular_function	protein homodimerization activity
G	0045039	biological_process	protein insertion into mitochondrial inner membrane
G	0051087	molecular_function	protein-folding chaperone binding
G	0090150	biological_process	establishment of protein localization to membrane
G	0140309	molecular_function	unfolded protein holdase activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
H	0005758	cellular_component	mitochondrial intermembrane space
H	0008270	molecular_function	zinc ion binding
H	0032977	molecular_function	membrane insertase activity
H	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
H	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
H	0042803	molecular_function	protein homodimerization activity
H	0045039	biological_process	protein insertion into mitochondrial inner membrane
H	0051087	molecular_function	protein-folding chaperone binding
H	0090150	biological_process	establishment of protein localization to membrane
H	0140309	molecular_function	unfolded protein holdase activity
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
I	0005758	cellular_component	mitochondrial intermembrane space
I	0008270	molecular_function	zinc ion binding
I	0032977	molecular_function	membrane insertase activity
I	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
I	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
I	0042803	molecular_function	protein homodimerization activity
I	0045039	biological_process	protein insertion into mitochondrial inner membrane
I	0051087	molecular_function	protein-folding chaperone binding
I	0090150	biological_process	establishment of protein localization to membrane
I	0140309	molecular_function	unfolded protein holdase activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005758	cellular_component	mitochondrial intermembrane space
J	0007160	biological_process	cell-matrix adhesion
J	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
J	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
J	0045039	biological_process	protein insertion into mitochondrial inner membrane
J	0051082	molecular_function	unfolded protein binding
J	0140318	molecular_function	protein transporter activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005758	cellular_component	mitochondrial intermembrane space
K	0008270	molecular_function	zinc ion binding
K	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
K	0042803	molecular_function	protein homodimerization activity
K	0045039	biological_process	protein insertion into mitochondrial inner membrane
K	0051087	molecular_function	protein-folding chaperone binding
K	0140309	molecular_function	unfolded protein holdase activity
K	0140318	molecular_function	protein transporter activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005758	cellular_component	mitochondrial intermembrane space
L	0008270	molecular_function	zinc ion binding
L	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
L	0042803	molecular_function	protein homodimerization activity
L	0045039	biological_process	protein insertion into mitochondrial inner membrane
L	0051087	molecular_function	protein-folding chaperone binding
L	0140309	molecular_function	unfolded protein holdase activity
L	0140318	molecular_function	protein transporter activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
M	0005758	cellular_component	mitochondrial intermembrane space
M	0008270	molecular_function	zinc ion binding
M	0032977	molecular_function	membrane insertase activity
M	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
M	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
M	0042803	molecular_function	protein homodimerization activity
M	0045039	biological_process	protein insertion into mitochondrial inner membrane
M	0051087	molecular_function	protein-folding chaperone binding
M	0090150	biological_process	establishment of protein localization to membrane
M	0140309	molecular_function	unfolded protein holdase activity
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
N	0005758	cellular_component	mitochondrial intermembrane space
N	0008270	molecular_function	zinc ion binding
N	0032977	molecular_function	membrane insertase activity
N	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
N	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
N	0042803	molecular_function	protein homodimerization activity
N	0045039	biological_process	protein insertion into mitochondrial inner membrane
N	0051087	molecular_function	protein-folding chaperone binding
N	0090150	biological_process	establishment of protein localization to membrane
N	0140309	molecular_function	unfolded protein holdase activity
O	0005515	molecular_function	protein binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
O	0005758	cellular_component	mitochondrial intermembrane space
O	0008270	molecular_function	zinc ion binding
O	0032977	molecular_function	membrane insertase activity
O	0042719	cellular_component	mitochondrial intermembrane space chaperone complex
O	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
O	0042803	molecular_function	protein homodimerization activity
O	0045039	biological_process	protein insertion into mitochondrial inner membrane
O	0051087	molecular_function	protein-folding chaperone binding
O	0090150	biological_process	establishment of protein localization to membrane
O	0140309	molecular_function	unfolded protein holdase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	141
Details	Domain: {"description":"DAGKc","evidences":[{"source":"PROSITE-ProRule","id":"PRU00783","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	294
Details	Motif: {"description":"Twin CX3C motif"}

Chain

Residue

Details

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