7CGP

Cryo-EM structure of the human mitochondrial translocase TIM22 complex at 3.7 angstrom.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0008320	molecular_function	protein transmembrane transporter activity
A	0015031	biological_process	protein transport
A	0030943	molecular_function	mitochondrion targeting sequence binding
A	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
A	0045039	biological_process	protein insertion into mitochondrial inner membrane
A	0071806	biological_process	protein transmembrane transport
A	0140318	molecular_function	protein transporter activity
B	0001727	molecular_function	lipid kinase activity
B	0001729	molecular_function	ceramide kinase activity
B	0004143	molecular_function	ATP-dependent diacylglycerol kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0031966	cellular_component	mitochondrial membrane
B	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0045039	biological_process	protein insertion into mitochondrial inner membrane
B	0046486	biological_process	glycerolipid metabolic process
B	0046513	biological_process	ceramide biosynthetic process
B	0046834	biological_process	lipid phosphorylation
B	0047620	molecular_function	acylglycerol kinase activity
B	0102773	molecular_function	dihydroceramide kinase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0015031	biological_process	protein transport
C	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
C	0045039	biological_process	protein insertion into mitochondrial inner membrane
C	0140318	molecular_function	protein transporter activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005758	cellular_component	mitochondrial intermembrane space
D	0006626	biological_process	protein targeting to mitochondrion
D	0007605	biological_process	sensory perception of sound
D	0008270	molecular_function	zinc ion binding
D	0015031	biological_process	protein transport
D	0032977	molecular_function	membrane insertase activity
D	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
D	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
D	0042803	molecular_function	protein homodimerization activity
D	0045039	biological_process	protein insertion into mitochondrial inner membrane
D	0046872	molecular_function	metal ion binding
D	0051087	molecular_function	protein-folding chaperone binding
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0006626	biological_process	protein targeting to mitochondrion
E	0007605	biological_process	sensory perception of sound
E	0008270	molecular_function	zinc ion binding
E	0015031	biological_process	protein transport
E	0032977	molecular_function	membrane insertase activity
E	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
E	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
E	0042803	molecular_function	protein homodimerization activity
E	0045039	biological_process	protein insertion into mitochondrial inner membrane
E	0046872	molecular_function	metal ion binding
E	0051087	molecular_function	protein-folding chaperone binding
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0006626	biological_process	protein targeting to mitochondrion
F	0007605	biological_process	sensory perception of sound
F	0008270	molecular_function	zinc ion binding
F	0015031	biological_process	protein transport
F	0032977	molecular_function	membrane insertase activity
F	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
F	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
F	0042803	molecular_function	protein homodimerization activity
F	0045039	biological_process	protein insertion into mitochondrial inner membrane
F	0046872	molecular_function	metal ion binding
F	0051087	molecular_function	protein-folding chaperone binding
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
G	0005758	cellular_component	mitochondrial intermembrane space
G	0006626	biological_process	protein targeting to mitochondrion
G	0007605	biological_process	sensory perception of sound
G	0008270	molecular_function	zinc ion binding
G	0015031	biological_process	protein transport
G	0032977	molecular_function	membrane insertase activity
G	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
G	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
G	0042803	molecular_function	protein homodimerization activity
G	0045039	biological_process	protein insertion into mitochondrial inner membrane
G	0046872	molecular_function	metal ion binding
G	0051087	molecular_function	protein-folding chaperone binding
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
H	0005758	cellular_component	mitochondrial intermembrane space
H	0006626	biological_process	protein targeting to mitochondrion
H	0007605	biological_process	sensory perception of sound
H	0008270	molecular_function	zinc ion binding
H	0015031	biological_process	protein transport
H	0032977	molecular_function	membrane insertase activity
H	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
H	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
H	0042803	molecular_function	protein homodimerization activity
H	0045039	biological_process	protein insertion into mitochondrial inner membrane
H	0046872	molecular_function	metal ion binding
H	0051087	molecular_function	protein-folding chaperone binding
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
I	0005758	cellular_component	mitochondrial intermembrane space
I	0006626	biological_process	protein targeting to mitochondrion
I	0007605	biological_process	sensory perception of sound
I	0008270	molecular_function	zinc ion binding
I	0015031	biological_process	protein transport
I	0032977	molecular_function	membrane insertase activity
I	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
I	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
I	0042803	molecular_function	protein homodimerization activity
I	0045039	biological_process	protein insertion into mitochondrial inner membrane
I	0046872	molecular_function	metal ion binding
I	0051087	molecular_function	protein-folding chaperone binding
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005758	cellular_component	mitochondrial intermembrane space
J	0007160	biological_process	cell-matrix adhesion
J	0015031	biological_process	protein transport
J	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
J	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
J	0045039	biological_process	protein insertion into mitochondrial inner membrane
J	0046872	molecular_function	metal ion binding
J	0051082	molecular_function	unfolded protein binding
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005758	cellular_component	mitochondrial intermembrane space
K	0006626	biological_process	protein targeting to mitochondrion
K	0007605	biological_process	sensory perception of sound
K	0008270	molecular_function	zinc ion binding
K	0015031	biological_process	protein transport
K	0032977	molecular_function	membrane insertase activity
K	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
K	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
K	0042803	molecular_function	protein homodimerization activity
K	0045039	biological_process	protein insertion into mitochondrial inner membrane
K	0046872	molecular_function	metal ion binding
K	0051087	molecular_function	protein-folding chaperone binding
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005758	cellular_component	mitochondrial intermembrane space
L	0006626	biological_process	protein targeting to mitochondrion
L	0007605	biological_process	sensory perception of sound
L	0008270	molecular_function	zinc ion binding
L	0015031	biological_process	protein transport
L	0032977	molecular_function	membrane insertase activity
L	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
L	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
L	0042803	molecular_function	protein homodimerization activity
L	0045039	biological_process	protein insertion into mitochondrial inner membrane
L	0046872	molecular_function	metal ion binding
L	0051087	molecular_function	protein-folding chaperone binding
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
M	0005758	cellular_component	mitochondrial intermembrane space
M	0006626	biological_process	protein targeting to mitochondrion
M	0007605	biological_process	sensory perception of sound
M	0008270	molecular_function	zinc ion binding
M	0015031	biological_process	protein transport
M	0032977	molecular_function	membrane insertase activity
M	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
M	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
M	0042803	molecular_function	protein homodimerization activity
M	0045039	biological_process	protein insertion into mitochondrial inner membrane
M	0046872	molecular_function	metal ion binding
M	0051087	molecular_function	protein-folding chaperone binding
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
N	0005758	cellular_component	mitochondrial intermembrane space
N	0006626	biological_process	protein targeting to mitochondrion
N	0007605	biological_process	sensory perception of sound
N	0008270	molecular_function	zinc ion binding
N	0015031	biological_process	protein transport
N	0032977	molecular_function	membrane insertase activity
N	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
N	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
N	0042803	molecular_function	protein homodimerization activity
N	0045039	biological_process	protein insertion into mitochondrial inner membrane
N	0046872	molecular_function	metal ion binding
N	0051087	molecular_function	protein-folding chaperone binding
O	0005515	molecular_function	protein binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
O	0005758	cellular_component	mitochondrial intermembrane space
O	0006626	biological_process	protein targeting to mitochondrion
O	0007605	biological_process	sensory perception of sound
O	0008270	molecular_function	zinc ion binding
O	0015031	biological_process	protein transport
O	0032977	molecular_function	membrane insertase activity
O	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
O	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
O	0042803	molecular_function	protein homodimerization activity
O	0045039	biological_process	protein insertion into mitochondrial inner membrane
O	0046872	molecular_function	metal ion binding
O	0051087	molecular_function	protein-folding chaperone binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
D	ALA2
E	ALA2
F	ALA2
K	ALA2
L	ALA2

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site_id	SWS_FT_FI2
Number of Residues	17
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	ALA60-ALA77

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site_id	SWS_FT_FI3
Number of Residues	182
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000305|PubMed:27554484, ECO:0000305|PubMed:27718247

Chain	Residue	Details
C	PRO78-ARG260

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