7CGE

The overall structure of nucleotide free MlaFEDB complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005548	molecular_function	phospholipid transporter activity
A	0005886	cellular_component	plasma membrane
A	0015914	biological_process	phospholipid transport
A	0016020	cellular_component	membrane
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0120010	biological_process	intermembrane phospholipid transfer
A	0120014	molecular_function	phospholipid transfer activity
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0015914	biological_process	phospholipid transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0120010	biological_process	intermembrane phospholipid transfer
B	0120014	molecular_function	phospholipid transfer activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006974	biological_process	DNA damage response
C	0015914	biological_process	phospholipid transport
C	0016020	cellular_component	membrane
C	0046677	biological_process	response to antibiotic
C	0120010	biological_process	intermembrane phospholipid transfer
C	0120014	molecular_function	phospholipid transfer activity
C	1990531	cellular_component	phospholipid-translocating ATPase complex
D	0005515	molecular_function	protein binding
D	0005548	molecular_function	phospholipid transporter activity
D	0005886	cellular_component	plasma membrane
D	0015914	biological_process	phospholipid transport
D	0016020	cellular_component	membrane
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0120010	biological_process	intermembrane phospholipid transfer
D	0120014	molecular_function	phospholipid transfer activity
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006869	biological_process	lipid transport
E	0015914	biological_process	phospholipid transport
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0120010	biological_process	intermembrane phospholipid transfer
E	0120014	molecular_function	phospholipid transfer activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006974	biological_process	DNA damage response
F	0015914	biological_process	phospholipid transport
F	0016020	cellular_component	membrane
F	0046677	biological_process	response to antibiotic
F	0120010	biological_process	intermembrane phospholipid transfer
F	0120014	molecular_function	phospholipid transfer activity
F	1990531	cellular_component	phospholipid-translocating ATPase complex
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005886	cellular_component	plasma membrane
G	0015914	biological_process	phospholipid transport
G	0016020	cellular_component	membrane
G	0120010	biological_process	intermembrane phospholipid transfer
G	0120014	molecular_function	phospholipid transfer activity
H	0005515	molecular_function	protein binding
H	0005543	molecular_function	phospholipid binding
H	0005886	cellular_component	plasma membrane
H	0015914	biological_process	phospholipid transport
H	0016020	cellular_component	membrane
H	0120010	biological_process	intermembrane phospholipid transfer
H	0120014	molecular_function	phospholipid transfer activity
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005886	cellular_component	plasma membrane
I	0015914	biological_process	phospholipid transport
I	0016020	cellular_component	membrane
I	0120010	biological_process	intermembrane phospholipid transfer
I	0120014	molecular_function	phospholipid transfer activity
J	0005515	molecular_function	protein binding
J	0005543	molecular_function	phospholipid binding
J	0005886	cellular_component	plasma membrane
J	0015914	biological_process	phospholipid transport
J	0016020	cellular_component	membrane
J	0120010	biological_process	intermembrane phospholipid transfer
J	0120014	molecular_function	phospholipid transfer activity
K	0005515	molecular_function	protein binding
K	0005543	molecular_function	phospholipid binding
K	0005886	cellular_component	plasma membrane
K	0015914	biological_process	phospholipid transport
K	0016020	cellular_component	membrane
K	0120010	biological_process	intermembrane phospholipid transfer
K	0120014	molecular_function	phospholipid transfer activity
L	0005515	molecular_function	protein binding
L	0005543	molecular_function	phospholipid binding
L	0005886	cellular_component	plasma membrane
L	0015914	biological_process	phospholipid transport
L	0016020	cellular_component	membrane
L	0120010	biological_process	intermembrane phospholipid transfer
L	0120014	molecular_function	phospholipid transfer activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PGW A 301

Chain	Residue
A	HIS241
A	GLY248
A	PGW302
D	LEU57
D	PGW301

---

site_id	AC2
Number of Residues	8
Details	binding site for residue PGW A 302

Chain	Residue
A	TRP215
A	ARG237
A	PGW301
A	PGW303
A	LYS15
A	THR16
A	PHE20
A	THR212

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PGW A 303

Chain	Residue
A	ARG196
A	PGW302
G	PGW201

---

site_id	AC4
Number of Residues	12
Details	binding site for residue PGW A 304

Chain	Residue
A	MET89
A	LEU90
A	LEU93
A	ARG97
A	GLU98
A	PGW306
D	GLN73
D	TYR81
G	LEU106
G	LEU107
K	LEU107
L	LEU106

---

site_id	AC5
Number of Residues	4
Details	binding site for residue PGW A 305

Chain	Residue
A	TYR49
A	LEU54
D	PGW302
G	TRP9

---

site_id	AC6
Number of Residues	11
Details	binding site for residue PGW A 306

Chain	Residue
A	GLN73
A	TYR81
A	PGW304
D	MET89
D	LEU90
D	LEU93
D	ARG97
D	GLU98
H	LEU107
I	LEU106
J	LEU107

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PGW D 301

Chain	Residue
A	PGW301
D	TYR49
D	LEU54
J	TRP9

---

site_id	AC8
Number of Residues	5
Details	binding site for residue PGW D 302

Chain	Residue
A	LEU57
A	PGW305
D	HIS241
D	GLY248
D	PGW303

---

site_id	AC9
Number of Residues	8
Details	binding site for residue PGW D 303

Chain	Residue
D	LYS15
D	THR16
D	PHE20
D	THR212
D	TRP215
D	ARG237
D	PGW302
D	PGW304

---

site_id	AD1
Number of Residues	3
Details	binding site for residue PGW D 304

Chain	Residue
D	ARG196
D	PGW303
J	PGW201

---

site_id	AD2
Number of Residues	4
Details	binding site for residue PGW G 201

Chain	Residue
A	TRP195
A	PGW303
G	ARG55
G	ARG67

---

site_id	AD3
Number of Residues	4
Details	binding site for residue PGW J 201

Chain	Residue
D	TRP195
D	PGW304
J	ARG55
J	ARG67

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGMARRAALARAI

Chain	Residue	Details
B	LEU145-ILE159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	200
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	90
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	110
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	472
Details	Domain: {"description":"ABC transporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	120
Details	Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	462
Details	Region: {"description":"MCE/MlaD","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---