7CGD
Silver-bound E.coli malate dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0006113 | biological_process | fermentation |
| A | 0009061 | biological_process | anaerobic respiration |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016615 | molecular_function | malate dehydrogenase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0019898 | cellular_component | extrinsic component of membrane |
| A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006096 | biological_process | glycolytic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0006113 | biological_process | fermentation |
| B | 0009061 | biological_process | anaerobic respiration |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016615 | molecular_function | malate dehydrogenase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0019898 | cellular_component | extrinsic component of membrane |
| B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006096 | biological_process | glycolytic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0006108 | biological_process | malate metabolic process |
| C | 0006113 | biological_process | fermentation |
| C | 0009061 | biological_process | anaerobic respiration |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016615 | molecular_function | malate dehydrogenase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0019898 | cellular_component | extrinsic component of membrane |
| C | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| C | 0042803 | molecular_function | protein homodimerization activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006096 | biological_process | glycolytic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006108 | biological_process | malate metabolic process |
| D | 0006113 | biological_process | fermentation |
| D | 0009061 | biological_process | anaerobic respiration |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016615 | molecular_function | malate dehydrogenase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0019898 | cellular_component | extrinsic component of membrane |
| D | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue AG A 401 |
| Chain | Residue |
| A | GLY69 |
| A | ALA70 |
| A | CYS109 |
| A | AG402 |
| A | HOH512 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue AG A 402 |
| Chain | Residue |
| A | THR108 |
| A | CYS109 |
| A | AG401 |
| A | HOH511 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue AG A 403 |
| Chain | Residue |
| A | ASP71 |
| A | LYS111 |
| A | CYS113 |
| A | LEU242 |
| A | AG404 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue AG A 404 |
| Chain | Residue |
| A | LYS111 |
| A | CYS113 |
| A | LYS142 |
| A | ASN273 |
| A | AG403 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue AG A 405 |
| Chain | Residue |
| A | PRO172 |
| A | VAL173 |
| A | CYS251 |
| A | AG406 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue AG A 406 |
| Chain | Residue |
| A | CYS251 |
| A | AG405 |
| A | HOH513 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue AG A 407 |
| Chain | Residue |
| A | ASN119 |
| A | HIS177 |
| A | MET227 |
| A | HOH509 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue AG B 401 |
| Chain | Residue |
| B | GLY69 |
| B | ALA70 |
| B | CYS109 |
| B | AG402 |
| B | HOH513 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue AG B 402 |
| Chain | Residue |
| B | THR108 |
| B | CYS109 |
| B | AG401 |
| B | HOH513 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue AG B 403 |
| Chain | Residue |
| B | ASP71 |
| B | CYS113 |
| B | LEU242 |
| B | AG404 |
| B | AG405 |
| B | HOH512 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue AG B 404 |
| Chain | Residue |
| B | LYS111 |
| B | CYS113 |
| B | LYS142 |
| B | ASN273 |
| B | AG403 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue AG B 405 |
| Chain | Residue |
| B | CYS113 |
| B | LEU238 |
| B | LEU242 |
| B | GLY274 |
| B | AG403 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue AG B 406 |
| Chain | Residue |
| B | CYS251 |
| B | AG407 |
| B | HOH511 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue AG B 407 |
| Chain | Residue |
| B | PRO172 |
| B | VAL173 |
| B | CYS251 |
| B | AG406 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue AG B 408 |
| Chain | Residue |
| B | ASN119 |
| B | HIS177 |
| B | MET227 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue AG C 401 |
| Chain | Residue |
| C | LYS111 |
| C | CYS113 |
| C | LYS142 |
| C | ASN273 |
| C | AG402 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue AG C 402 |
| Chain | Residue |
| C | ASP71 |
| C | CYS113 |
| C | LEU242 |
| C | AG401 |
| C | HOH509 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue AG C 403 |
| Chain | Residue |
| C | CYS113 |
| C | LEU238 |
| C | LEU242 |
| C | GLY274 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue AG C 404 |
| Chain | Residue |
| C | PRO172 |
| C | VAL173 |
| C | CYS251 |
| C | AG405 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue AG C 405 |
| Chain | Residue |
| C | CYS251 |
| C | AG404 |
| C | HOH510 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue AG C 406 |
| Chain | Residue |
| C | ASN119 |
| C | HIS177 |
| C | MET227 |
| C | HOH508 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue AG D 401 |
| Chain | Residue |
| D | GLY69 |
| D | ALA70 |
| D | CYS109 |
| D | AG402 |
| D | HOH510 |
| D | HOH513 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue AG D 402 |
| Chain | Residue |
| D | HOH513 |
| D | THR108 |
| D | CYS109 |
| D | AG401 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue AG D 403 |
| Chain | Residue |
| D | ASP71 |
| D | CYS113 |
| D | AG404 |
| D | HOH508 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue AG D 404 |
| Chain | Residue |
| D | CYS113 |
| D | LEU238 |
| D | LEU242 |
| D | GLY274 |
| D | AG403 |
| D | HOH501 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue AG D 405 |
| Chain | Residue |
| D | CYS251 |
| D | AG406 |
| D | HOH512 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue AG D 406 |
| Chain | Residue |
| D | PRO172 |
| D | VAL173 |
| D | CYS251 |
| D | AG405 |
Functional Information from PROSITE/UniProt
| site_id | PS00068 |
| Number of Residues | 13 |
| Details | MDH Malate dehydrogenase active site signature. VTTLDiiRSntfV |
| Chain | Residue | Details |
| A | VAL146-VAL158 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01516","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11389141","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01516","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11389141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8331658","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01516","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1507230","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8331658","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 527 |
| Chain | Residue | Details |
| A | ASP150 | modifies pKa |
| A | HIS177 | proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 527 |
| Chain | Residue | Details |
| B | ASP150 | modifies pKa |
| B | HIS177 | proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 527 |
| Chain | Residue | Details |
| C | ASP150 | modifies pKa |
| C | HIS177 | proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 527 |
| Chain | Residue | Details |
| D | ASP150 | modifies pKa |
| D | HIS177 | proton acceptor, proton donor |
