7CGC
Silver-bound E. coli Malate dehydrogenase (C113 and C251)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006096 | biological_process | glycolytic process |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0006108 | biological_process | malate metabolic process |
A | 0006113 | biological_process | fermentation |
A | 0009061 | biological_process | anaerobic respiration |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016615 | molecular_function | malate dehydrogenase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
A | 0019898 | cellular_component | extrinsic component of membrane |
A | 0030060 | molecular_function | L-malate dehydrogenase activity |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006096 | biological_process | glycolytic process |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0006108 | biological_process | malate metabolic process |
B | 0006113 | biological_process | fermentation |
B | 0009061 | biological_process | anaerobic respiration |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016615 | molecular_function | malate dehydrogenase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0019898 | cellular_component | extrinsic component of membrane |
B | 0030060 | molecular_function | L-malate dehydrogenase activity |
B | 0042803 | molecular_function | protein homodimerization activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006096 | biological_process | glycolytic process |
C | 0006099 | biological_process | tricarboxylic acid cycle |
C | 0006108 | biological_process | malate metabolic process |
C | 0006113 | biological_process | fermentation |
C | 0009061 | biological_process | anaerobic respiration |
C | 0016020 | cellular_component | membrane |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016615 | molecular_function | malate dehydrogenase activity |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0019898 | cellular_component | extrinsic component of membrane |
C | 0030060 | molecular_function | L-malate dehydrogenase activity |
C | 0042803 | molecular_function | protein homodimerization activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006096 | biological_process | glycolytic process |
D | 0006099 | biological_process | tricarboxylic acid cycle |
D | 0006108 | biological_process | malate metabolic process |
D | 0006113 | biological_process | fermentation |
D | 0009061 | biological_process | anaerobic respiration |
D | 0016020 | cellular_component | membrane |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016615 | molecular_function | malate dehydrogenase activity |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0019898 | cellular_component | extrinsic component of membrane |
D | 0030060 | molecular_function | L-malate dehydrogenase activity |
D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue AG A 401 |
Chain | Residue |
A | ASP71 |
A | CYS113 |
A | LEU242 |
A | AG402 |
A | HOH502 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue AG A 402 |
Chain | Residue |
A | CYS113 |
A | LYS142 |
A | ASN273 |
A | AG401 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue AG A 403 |
Chain | Residue |
A | ILE151 |
A | PRO172 |
A | VAL173 |
A | CYS251 |
A | AG404 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue AG A 404 |
Chain | Residue |
A | CYS251 |
A | AG403 |
A | HOH504 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue AG B 401 |
Chain | Residue |
B | ASP71 |
B | CYS113 |
B | LEU242 |
B | AG402 |
B | HOH502 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue AG B 402 |
Chain | Residue |
B | CYS113 |
B | LYS142 |
B | ASN273 |
B | GLY274 |
B | AG401 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue AG B 403 |
Chain | Residue |
B | ILE151 |
B | PRO172 |
B | VAL173 |
B | CYS251 |
B | AG404 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue AG B 404 |
Chain | Residue |
B | CYS251 |
B | AG403 |
B | HOH504 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue AG C 401 |
Chain | Residue |
C | ASP71 |
C | LYS111 |
C | CYS113 |
C | LYS142 |
C | AG402 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue AG C 402 |
Chain | Residue |
C | CYS113 |
C | LEU238 |
C | LEU242 |
C | GLY274 |
C | AG401 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue AG C 403 |
Chain | Residue |
C | CYS251 |
C | AG404 |
C | HOH503 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue AG C 404 |
Chain | Residue |
C | PRO172 |
C | VAL173 |
C | CYS251 |
C | AG403 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue AG D 401 |
Chain | Residue |
D | ASP71 |
D | CYS113 |
D | LEU242 |
D | AG402 |
D | HOH503 |
site_id | AD5 |
Number of Residues | 3 |
Details | binding site for residue AG D 402 |
Chain | Residue |
D | CYS113 |
D | LYS142 |
D | AG401 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue AG D 403 |
Chain | Residue |
D | CYS251 |
D | AG404 |
D | HOH502 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue AG D 404 |
Chain | Residue |
D | ILE151 |
D | PRO172 |
D | VAL173 |
D | CYS251 |
D | AG403 |
Functional Information from PROSITE/UniProt
site_id | PS00068 |
Number of Residues | 13 |
Details | MDH Malate dehydrogenase active site signature. VTTLDiiRSntfV |
Chain | Residue | Details |
A | VAL146-VAL158 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000305|PubMed:11389141 |
Chain | Residue | Details |
A | HIS177 | |
B | HIS177 | |
C | HIS177 | |
D | HIS177 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:11389141, ECO:0000269|PubMed:8331658 |
Chain | Residue | Details |
A | MET227 | |
B | GLY7 | |
B | ASP34 | |
B | ASN94 | |
B | ILE117 | |
B | MET227 | |
C | GLY7 | |
C | ASP34 | |
C | ASN94 | |
C | ILE117 | |
C | MET227 | |
D | GLY7 | |
D | ASP34 | |
D | ASN94 | |
D | ILE117 | |
D | MET227 | |
A | GLY7 | |
A | ASP34 | |
A | ASN94 | |
A | ILE117 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000305|PubMed:1507230, ECO:0000305|PubMed:8331658 |
Chain | Residue | Details |
D | ARG81 | |
D | ARG87 | |
D | ASN119 | |
D | ARG153 | |
A | ARG81 | |
A | ARG87 | |
A | ASN119 | |
A | ARG153 | |
B | ARG81 | |
B | ARG87 | |
B | ASN119 | |
B | ARG153 | |
C | ARG81 | |
C | ARG87 | |
C | ASN119 | |
C | ARG153 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 2 |
Details | M-CSA 527 |
Chain | Residue | Details |
A | ASP150 | modifies pKa |
A | HIS177 | proton acceptor, proton donor |
site_id | MCSA2 |
Number of Residues | 2 |
Details | M-CSA 527 |
Chain | Residue | Details |
B | ASP150 | modifies pKa |
B | HIS177 | proton acceptor, proton donor |
site_id | MCSA3 |
Number of Residues | 2 |
Details | M-CSA 527 |
Chain | Residue | Details |
C | ASP150 | modifies pKa |
C | HIS177 | proton acceptor, proton donor |
site_id | MCSA4 |
Number of Residues | 2 |
Details | M-CSA 527 |
Chain | Residue | Details |
D | ASP150 | modifies pKa |
D | HIS177 | proton acceptor, proton donor |