Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7CFU

Crystal Structure of FMN-dependent Cysteine Decarboxylases SpaF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
A	0010181	molecular_function	FMN binding
A	0015937	biological_process	coenzyme A biosynthetic process
A	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
B	0010181	molecular_function	FMN binding
B	0015937	biological_process	coenzyme A biosynthetic process
B	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
C	0010181	molecular_function	FMN binding
C	0015937	biological_process	coenzyme A biosynthetic process
C	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
D	0010181	molecular_function	FMN binding
D	0015937	biological_process	coenzyme A biosynthetic process
D	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
E	0010181	molecular_function	FMN binding
E	0015937	biological_process	coenzyme A biosynthetic process
E	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
F	0010181	molecular_function	FMN binding
F	0015937	biological_process	coenzyme A biosynthetic process
F	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
G	0010181	molecular_function	FMN binding
G	0015937	biological_process	coenzyme A biosynthetic process
G	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
H	0010181	molecular_function	FMN binding
H	0015937	biological_process	coenzyme A biosynthetic process
H	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
I	0000166	molecular_function	nucleotide binding
I	0003824	molecular_function	catalytic activity
I	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
I	0010181	molecular_function	FMN binding
I	0015937	biological_process	coenzyme A biosynthetic process
I	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
J	0000166	molecular_function	nucleotide binding
J	0003824	molecular_function	catalytic activity
J	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
J	0010181	molecular_function	FMN binding
J	0015937	biological_process	coenzyme A biosynthetic process
J	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
K	0000166	molecular_function	nucleotide binding
K	0003824	molecular_function	catalytic activity
K	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
K	0010181	molecular_function	FMN binding
K	0015937	biological_process	coenzyme A biosynthetic process
K	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
L	0000166	molecular_function	nucleotide binding
L	0003824	molecular_function	catalytic activity
L	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
L	0010181	molecular_function	FMN binding
L	0015937	biological_process	coenzyme A biosynthetic process
L	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
M	0000166	molecular_function	nucleotide binding
M	0003824	molecular_function	catalytic activity
M	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
M	0010181	molecular_function	FMN binding
M	0015937	biological_process	coenzyme A biosynthetic process
M	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
N	0000166	molecular_function	nucleotide binding
N	0003824	molecular_function	catalytic activity
N	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
N	0010181	molecular_function	FMN binding
N	0015937	biological_process	coenzyme A biosynthetic process
N	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
O	0000166	molecular_function	nucleotide binding
O	0003824	molecular_function	catalytic activity
O	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
O	0010181	molecular_function	FMN binding
O	0015937	biological_process	coenzyme A biosynthetic process
O	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
P	0000166	molecular_function	nucleotide binding
P	0003824	molecular_function	catalytic activity
P	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
P	0010181	molecular_function	FMN binding
P	0015937	biological_process	coenzyme A biosynthetic process
P	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
Q	0000166	molecular_function	nucleotide binding
Q	0003824	molecular_function	catalytic activity
Q	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
Q	0010181	molecular_function	FMN binding
Q	0015937	biological_process	coenzyme A biosynthetic process
Q	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
R	0000166	molecular_function	nucleotide binding
R	0003824	molecular_function	catalytic activity
R	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
R	0010181	molecular_function	FMN binding
R	0015937	biological_process	coenzyme A biosynthetic process
R	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
S	0000166	molecular_function	nucleotide binding
S	0003824	molecular_function	catalytic activity
S	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
S	0010181	molecular_function	FMN binding
S	0015937	biological_process	coenzyme A biosynthetic process
S	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
T	0000166	molecular_function	nucleotide binding
T	0003824	molecular_function	catalytic activity
T	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
T	0010181	molecular_function	FMN binding
T	0015937	biological_process	coenzyme A biosynthetic process
T	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
U	0000166	molecular_function	nucleotide binding
U	0003824	molecular_function	catalytic activity
U	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
U	0010181	molecular_function	FMN binding
U	0015937	biological_process	coenzyme A biosynthetic process
U	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
V	0000166	molecular_function	nucleotide binding
V	0003824	molecular_function	catalytic activity
V	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
V	0010181	molecular_function	FMN binding
V	0015937	biological_process	coenzyme A biosynthetic process
V	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
W	0000166	molecular_function	nucleotide binding
W	0003824	molecular_function	catalytic activity
W	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
W	0010181	molecular_function	FMN binding
W	0015937	biological_process	coenzyme A biosynthetic process
W	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
X	0000166	molecular_function	nucleotide binding
X	0003824	molecular_function	catalytic activity
X	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
X	0010181	molecular_function	FMN binding
X	0015937	biological_process	coenzyme A biosynthetic process
X	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue FMN F 301

Chain	Residue
D	ALA72
F	ASN110
F	VAL140
F	MET141
F	MET145
F	HOH405
F	HOH421
F	HOH431
F	HOH432
F	HOH439
F	HOH441
F	CYS29
F	HOH444
H	TRP82
H	GLY89
H	ALA90
H	HIS92
H	ALA120
H	ASP121
F	GLY30
F	SER31
F	PHE32
F	THR58
F	GLN60
F	THR108
F	ALA109

site_id	AC2
Number of Residues	3
Details	binding site for residue ARG S 301

Chain	Residue
S	GLN197
S	ALA198
S	ALA200

site_id	AC3
Number of Residues	22
Details	binding site for residue FMN S 302

Chain	Residue
L	ALA72
S	CYS29
S	GLY30
S	SER31
S	PHE32
S	THR58
S	GLN60
S	THR108
S	ALA109
S	ASN110
S	VAL140
S	MET141
S	MET145
S	HOH414
S	HOH418
S	HOH431
S	HOH445
S	HOH450
T	TRP82
T	HIS92
T	ALA120
T	ASP121

site_id	AC4
Number of Residues	24
Details	binding site for residue FMN H 301

Chain	Residue
H	CYS29
H	GLY30
H	SER31
H	PHE32
H	THR58
H	GLN60
H	THR108
H	ALA109
H	ASN110
H	VAL140
H	MET145
H	HOH407
H	HOH412
H	HOH423
H	HOH431
H	HOH432
H	HOH439
H	HOH460
P	TRP82
P	ALA90
P	HIS92
P	ALA120
P	ASP121
T	ALA72

site_id	AC5
Number of Residues	23
Details	binding site for residue FMN P 301

Chain	Residue
F	TRP82
F	ALA90
F	HIS92
F	ALA120
F	ASP121
N	ALA72
P	CYS29
P	GLY30
P	SER31
P	PHE32
P	THR58
P	GLN60
P	THR108
P	ALA109
P	ASN110
P	VAL140
P	MET145
P	HOH404
P	HOH409
P	HOH419
P	HOH421
P	HOH428
P	HOH447

site_id	AC6
Number of Residues	25
Details	binding site for residue FMN A 301

Chain	Residue
A	GLY30
A	SER31
A	PHE32
A	THR58
A	GLN60
A	THR108
A	ALA109
A	ASN110
A	VAL140
A	MET145
A	HOH417
A	HOH424
A	HOH428
A	HOH431
A	HOH438
A	HOH441
B	TRP82
B	GLY89
B	ALA90
B	HIS92
B	ALA120
B	ASP121
B	HOH426
I	ALA72
A	CYS29

site_id	AC7
Number of Residues	23
Details	binding site for residue FMN B 301

Chain	Residue
B	CYS29
B	GLY30
B	SER31
B	PHE32
B	THR58
B	GLN60
B	THR108
B	ALA109
B	ASN110
B	VAL140
B	MET145
B	HOH408
B	HOH421
B	HOH422
B	HOH436
B	HOH444
C	TRP82
C	ALA90
C	HIS92
C	ALA120
C	ASP121
C	HOH451
W	ALA72

site_id	AC8
Number of Residues	22
Details	binding site for residue FMN C 301

Chain	Residue
A	TRP82
A	ALA90
A	HIS92
A	ALA120
A	ASP121
C	CYS29
C	GLY30
C	SER31
C	PHE32
C	THR58
C	GLN60
C	THR108
C	ALA109
C	ASN110
C	VAL140
C	MET145
C	HOH408
C	HOH414
C	HOH415
C	HOH420
C	HOH424
C	HOH456

site_id	AC9
Number of Residues	25
Details	binding site for residue FMN D 301

Chain	Residue
D	CYS29
D	GLY30
D	SER31
D	PHE32
D	THR58
D	GLN60
D	THR108
D	ALA109
D	ASN110
D	VAL140
D	MET141
D	MET145
D	HOH412
D	HOH431
D	HOH435
D	HOH437
D	HOH451
D	HOH460
D	HOH461
E	TRP82
E	ALA90
E	HIS92
E	ALA120
E	ASP121
F	ALA72

site_id	AD1
Number of Residues	25
Details	binding site for residue FMN E 301

Chain	Residue
E	CYS29
E	GLY30
E	SER31
E	PHE32
E	THR58
E	GLN60
E	THR108
E	ALA109
E	ASN110
E	VAL140
E	MET145
E	HOH408
E	HOH418
E	HOH421
E	HOH431
E	HOH435
E	HOH443
E	HOH447
E	HOH457
G	TRP82
G	ALA90
G	HIS92
G	ALA120
G	ASP121
M	ALA72

site_id	AD2
Number of Residues	26
Details	binding site for residue FMN G 301

Chain	Residue
D	TRP82
D	ALA90
D	HIS92
D	ALA120
D	ASP121
G	CYS29
G	GLY30
G	SER31
G	PHE32
G	THR58
G	GLN60
G	THR108
G	ALA109
G	ASN110
G	VAL140
G	MET141
G	MET145
G	HOH412
G	HOH428
G	HOH436
G	HOH440
G	HOH448
G	HOH449
G	HOH453
G	HOH463
U	ALA72

site_id	AD3
Number of Residues	23
Details	binding site for residue FMN I 301

Chain	Residue
A	ALA72
I	CYS29
I	GLY30
I	SER31
I	PHE32
I	THR58
I	GLN60
I	THR108
I	ALA109
I	ASN110
I	VAL140
I	MET145
I	HOH407
I	HOH424
I	HOH429
I	HOH443
I	HOH447
J	TRP82
J	ALA90
J	HIS92
J	ALA120
J	ASP121
J	HOH412

site_id	AD4
Number of Residues	24
Details	binding site for residue FMN J 301

Chain	Residue
J	CYS29
J	GLY30
J	SER31
J	PHE32
J	THR58
J	GLN60
J	THR108
J	ALA109
J	ASN110
J	VAL140
J	MET141
J	MET145
J	HOH415
J	HOH417
J	HOH421
J	HOH435
J	HOH439
K	TRP82
K	GLY89
K	ALA90
K	HIS92
K	ALA120
K	ASP121
K	HOH427

site_id	AD5
Number of Residues	23
Details	binding site for residue FMN K 301

Chain	Residue
I	TRP82
I	ALA90
I	HIS92
I	ALA120
I	ASP121
K	CYS29
K	GLY30
K	SER31
K	PHE32
K	THR58
K	GLN60
K	THR108
K	ALA109
K	ASN110
K	VAL140
K	MET145
K	HOH413
K	HOH416
K	HOH417
K	HOH419
K	HOH426
K	HOH428
K	HOH438

site_id	AD6
Number of Residues	25
Details	binding site for residue FMN L 301

Chain	Residue
L	CYS29
L	GLY30
L	SER31
L	PHE32
L	THR58
L	GLN60
L	THR108
L	ALA109
L	ASN110
L	VAL140
L	MET141
L	MET145
L	HOH404
L	HOH408
L	HOH420
L	HOH422
L	HOH427
L	HOH450
M	TRP82
M	ALA90
M	HIS92
M	ALA120
M	ASP121
M	HOH444
S	ALA72

site_id	AD7
Number of Residues	25
Details	binding site for residue FMN M 301

Chain	Residue
E	ALA72
M	CYS29
M	GLY30
M	SER31
M	PHE32
M	THR58
M	GLN60
M	THR108
M	ALA109
M	ASN110
M	VAL140
M	MET145
M	HOH402
M	HOH422
M	HOH423
M	HOH434
M	HOH438
M	HOH443
M	HOH450
N	TRP82
N	GLY89
N	ALA90
N	HIS92
N	ALA120
N	ASP121

site_id	AD8
Number of Residues	25
Details	binding site for residue FMN N 301

Chain	Residue
L	TRP82
L	ALA90
L	HIS92
L	ALA120
L	ASP121
L	HOH438
L	HOH444
N	CYS29
N	GLY30
N	SER31
N	PHE32
N	THR58
N	GLN60
N	THR108
N	ALA109
N	ASN110
N	VAL140
N	MET145
N	HOH410
N	HOH412
N	HOH417
N	HOH421
N	HOH425
N	HOH428
P	ALA72

site_id	AD9
Number of Residues	22
Details	binding site for residue FMN O 301

Chain	Residue
O	CYS29
O	GLY30
O	SER31
O	PHE32
O	THR58
O	GLN60
O	THR108
O	ALA109
O	ASN110
O	VAL140
O	MET145
O	HOH413
O	HOH414
O	HOH422
O	HOH433
O	HOH439
Q	TRP82
Q	ALA90
Q	HIS92
Q	ALA120
Q	ASP121
Q	HOH437

site_id	AE1
Number of Residues	23
Details	binding site for residue FMN Q 301

Chain	Residue
Q	CYS29
Q	GLY30
Q	SER31
Q	PHE32
Q	THR58
Q	GLN60
Q	THR108
Q	ALA109
Q	ASN110
Q	VAL140
Q	MET145
Q	HOH403
Q	HOH420
Q	HOH421
Q	HOH422
Q	HOH423
Q	HOH428
Q	HOH432
R	TRP82
R	ALA90
R	HIS92
R	ALA120
R	ASP121

site_id	AE2
Number of Residues	25
Details	binding site for residue FMN R 301

Chain	Residue
O	TRP82
O	ALA90
O	HIS92
O	ALA120
O	ASP121
O	HOH431
O	HOH443
R	CYS29
R	GLY30
R	SER31
R	PHE32
R	THR58
R	GLN60
R	THR108
R	ALA109
R	ASN110
R	VAL140
R	MET141
R	MET145
R	HOH410
R	HOH417
R	HOH419
R	HOH421
R	HOH423
R	HOH425

site_id	AE3
Number of Residues	21
Details	binding site for residue FMN T 301

Chain	Residue
H	ALA72
T	CYS29
T	GLY30
T	SER31
T	PHE32
T	THR58
T	GLN60
T	THR108
T	ALA109
T	ASN110
T	VAL140
T	MET145
T	HOH408
T	HOH409
T	HOH411
T	HOH415
U	TRP82
U	ALA90
U	HIS92
U	ALA120
U	ASP121

site_id	AE4
Number of Residues	23
Details	binding site for residue FMN U 301

Chain	Residue
G	ALA72
S	TRP82
S	ALA90
S	HIS92
S	ALA120
S	ASP121
S	HOH409
U	CYS29
U	GLY30
U	SER31
U	PHE32
U	THR58
U	GLN60
U	THR108
U	ALA109
U	ASN110
U	VAL140
U	MET145
U	HOH407
U	HOH411
U	HOH418
U	HOH419
U	HOH422

site_id	AE5
Number of Residues	23
Details	binding site for residue FMN V 301

Chain	Residue
V	CYS29
V	GLY30
V	SER31
V	PHE32
V	THR58
V	GLN60
V	THR108
V	ALA109
V	ASN110
V	VAL140
V	MET141
V	MET145
V	HOH406
V	HOH412
V	HOH429
V	HOH433
V	HOH439
V	HOH443
W	TRP82
W	ALA90
W	HIS92
W	ALA120
W	ASP121

site_id	AE6
Number of Residues	22
Details	binding site for residue FMN W 301

Chain	Residue
B	ALA72
W	GLY30
W	SER31
W	PHE32
W	THR58
W	GLN60
W	THR108
W	ALA109
W	ASN110
W	VAL140
W	MET145
W	HOH408
W	HOH423
W	HOH424
W	HOH426
W	HOH437
X	TRP82
X	GLY89
X	ALA90
X	HIS92
X	ALA120
X	ASP121

site_id	AE7
Number of Residues	21
Details	binding site for residue FMN X 301

Chain	Residue
K	ALA72
V	TRP82
V	ALA90
V	HIS92
V	ALA120
V	ASP121
X	CYS29
X	GLY30
X	SER31
X	PHE32
X	THR58
X	GLN60
X	THR108
X	ALA109
X	ASN110
X	VAL140
X	MET145
X	HOH404
X	HOH417
X	HOH429
X	HOH435

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)