7CD1
Crystal structure of inhibitory Smad, Smad7
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | GLY274 |
| A | ARG275 |
| A | LEU301 |
| A | HOH602 |
| A | HOH633 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | ARG258 |
| A | HOH741 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 503 |
| Chain | Residue |
| A | LYS359 |
| B | HOH721 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | GLN410 |
| A | SER414 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| B | PHE341 |
| B | LYS359 |
| B | TYR407 |
| B | HOH619 |
| B | HOH662 |
| B | HOH690 |
| D | TYR407 |
| D | THR408 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | TYR407 |
| B | THR408 |
| B | ARG409 |
| B | HOH631 |
| B | HOH642 |
| D | LYS401 |
| D | ARG409 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 501 |
| Chain | Residue |
| A | HOH640 |
| C | GLY274 |
| C | ARG275 |
| C | LEU301 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 C 502 |
| Chain | Residue |
| A | LYS312 |
| A | LYS316 |
| B | GLN292 |
| C | SER337 |
| C | TYR338 |
| C | HOH641 |
| C | HOH647 |
| C | HOH651 |
| C | HOH678 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 503 |
| Chain | Residue |
| C | LYS401 |
| C | THR408 |
| C | ARG409 |
| C | HOH601 |
| C | HOH677 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 C 504 |
| Chain | Residue |
| A | SER337 |
| A | TYR338 |
| A | HOH650 |
| A | HOH655 |
| C | PRO339 |
| C | LYS359 |
| C | HOH602 |
| C | HOH603 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL C 505 |
| Chain | Residue |
| C | ARG258 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 506 |
| Chain | Residue |
| C | GLN410 |
| C | SER414 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 D 501 |
| Chain | Residue |
| B | LYS316 |
| B | TYR338 |
| B | HOH617 |
| D | THR408 |
| D | ARG409 |
| D | GLN410 |
| D | PHE411 |
| D | SER414 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 502 |
| Chain | Residue |
| D | ARG275 |
| D | LEU301 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 503 |
| Chain | Residue |
| B | HOH721 |
| D | ARG258 |
| D | HOH657 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 660 |
| Details | Domain: {"description":"MH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00439","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00439","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11278814","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
