7CC8
Crystal structure of White Spot Syndrome Virus Thymidylate Synthase - Apo form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | ARG150 |
| A | ARG151 |
| B | ARG190 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ARG249 |
| A | PRO278 |
| A | SER280 |
| A | SO4303 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLY281 |
| A | ASN282 |
| A | LEU283 |
| A | GLN284 |
| A | SO4302 |
| A | HOH466 |
| A | HIS279 |
| A | SER280 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | ARG68 |
| A | ARG115 |
| A | HIS116 |
| A | GLU264 |
| A | HOH433 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | ARG115 |
| A | LEU140 |
| A | MET215 |
| A | LYS262 |
| A | ILE263 |
| A | GLU264 |
| A | HOH403 |
| A | HOH445 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue PGE A 306 |
| Chain | Residue |
| A | GLN135 |
| A | ASN138 |
| A | ILE139 |
| A | THR142 |
| A | ASP149 |
| A | ARG151 |
| A | ILE153 |
| A | HOH440 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| A | ARG190 |
| A | SER191 |
| B | ARG150 |
| B | ARG151 |
| B | HOH458 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PGE B 302 |
| Chain | Residue |
| B | ILE133 |
| B | GLN135 |
| B | ASN138 |
| B | THR142 |
| B | ASP149 |
| B | ARG151 |
| B | ILE153 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PGE B 303 |
| Chain | Residue |
| B | GLU62 |
| B | ILE83 |
| B | ASN87 |
| B | LEU167 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrmImtaWNpmdlhlma.....LpPCHmtaQFyV |
| Chain | Residue | Details |
| A | ARG150-VAL178 |
