7CBI
Crystal structure of threonyl-tRNA synthetase (ThrRS) from Salmonella enterica in complex with an inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004829 | molecular_function | threonine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006435 | biological_process | threonyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004829 | molecular_function | threonine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006435 | biological_process | threonyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS334 |
| A | HIS385 |
| A | HIS511 |
| A | FQU702 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue FQU A 702 |
| Chain | Residue |
| A | ARG363 |
| A | GLN381 |
| A | ASP383 |
| A | HIS385 |
| A | HIS511 |
| A | ZN701 |
| A | HOH1126 |
| A | TYR313 |
| A | ALA316 |
| A | PRO331 |
| A | MET332 |
| A | CYS334 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 703 |
| Chain | Residue |
| A | ARG349 |
| A | PRO352 |
| A | HOH900 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 701 |
| Chain | Residue |
| A | LYS294 |
| A | GLY295 |
| A | PRO296 |
| B | VAL264 |
| B | TRP266 |
| B | GLU519 |
| B | HOH850 |
| B | HOH910 |
| B | HOH943 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 702 |
| Chain | Residue |
| B | CYS334 |
| B | HIS385 |
| B | HIS511 |
| B | FQU703 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue FQU B 703 |
| Chain | Residue |
| B | TYR313 |
| B | ALA316 |
| B | PRO331 |
| B | MET332 |
| B | CYS334 |
| B | HIS362 |
| B | ARG363 |
| B | GLN381 |
| B | ASP383 |
| B | HIS385 |
| B | TYR462 |
| B | LYS465 |
| B | THR482 |
| B | GLN484 |
| B | HIS511 |
| B | ARG512 |
| B | ALA513 |
| B | ZN702 |
| B | HOH900 |
| B | HOH979 |
