7CB5

The 6-phosphogluconate dehydrogenase from Staphylococcus aureus (6-phosphogluconate bound)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
A	0005829	cellular_component	cytosol
A	0006098	biological_process	pentose-phosphate shunt
A	0008114	molecular_function	phosphogluconate 2-dehydrogenase activity
A	0009051	biological_process	pentose-phosphate shunt, oxidative branch
A	0016054	biological_process	organic acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019521	biological_process	D-gluconate metabolic process
A	0046177	biological_process	D-gluconate catabolic process
A	0050661	molecular_function	NADP binding
B	0000166	molecular_function	nucleotide binding
B	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
B	0005829	cellular_component	cytosol
B	0006098	biological_process	pentose-phosphate shunt
B	0008114	molecular_function	phosphogluconate 2-dehydrogenase activity
B	0009051	biological_process	pentose-phosphate shunt, oxidative branch
B	0016054	biological_process	organic acid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0019521	biological_process	D-gluconate metabolic process
B	0046177	biological_process	D-gluconate catabolic process
B	0050661	molecular_function	NADP binding
C	0000166	molecular_function	nucleotide binding
C	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
C	0005829	cellular_component	cytosol
C	0006098	biological_process	pentose-phosphate shunt
C	0008114	molecular_function	phosphogluconate 2-dehydrogenase activity
C	0009051	biological_process	pentose-phosphate shunt, oxidative branch
C	0016054	biological_process	organic acid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0019521	biological_process	D-gluconate metabolic process
C	0046177	biological_process	D-gluconate catabolic process
C	0050661	molecular_function	NADP binding
D	0000166	molecular_function	nucleotide binding
D	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
D	0005829	cellular_component	cytosol
D	0006098	biological_process	pentose-phosphate shunt
D	0008114	molecular_function	phosphogluconate 2-dehydrogenase activity
D	0009051	biological_process	pentose-phosphate shunt, oxidative branch
D	0016054	biological_process	organic acid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0019521	biological_process	D-gluconate metabolic process
D	0046177	biological_process	D-gluconate catabolic process
D	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 6PG A 501

Chain	Residue
A	SER127
A	ARG286
A	ILE364
A	HOH608
B	ARG444
B	PHE447
B	HIS450
A	GLY128
A	GLY129
A	LYS182
A	HIS185
A	ASN186
A	TYR190
A	LYS259
A	THR261

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site_id	AC2
Number of Residues	17
Details	binding site for residue 6PG B 501

Chain	Residue
A	ARG444
A	HIS450
B	ASN101
B	SER127
B	GLY128
B	GLY129
B	LYS182
B	HIS185
B	ASN186
B	GLU189
B	TYR190
B	GLN258
B	LYS259
B	ARG286
B	ILE364
B	HOH609
B	HOH620

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site_id	AC3
Number of Residues	15
Details	binding site for residue 6PG C 501

Chain	Residue
C	VAL126
C	SER127
C	GLY128
C	LYS182
C	HIS185
C	ASN186
C	GLU189
C	TYR190
C	GLN258
C	LYS259
C	ARG286
C	ILE364
D	ARG444
D	PHE447
D	HIS450

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site_id	AC4
Number of Residues	15
Details	binding site for residue 6PG D 501

Chain	Residue
C	ARG444
C	HIS450
D	SER127
D	GLY128
D	GLY129
D	LYS182
D	ASN186
D	GLU189
D	TYR190
D	GLY257
D	GLN258
D	LYS259
D	THR261
D	ARG286
D	ILE364

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Functional Information from PROSITE/UniProt

site_id	PS00461
Number of Residues	13
Details	6PGD 6-phosphogluconate dehydrogenase signature. IlDtaGQKGTGkW

Chain	Residue	Details
A	ILE252-TRP264

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