7CB2

The 6-phosphogluconate dehydrogenase (NADP-bound) from Staphylococcus aureus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
A	0005829	cellular_component	cytosol
A	0006098	biological_process	pentose-phosphate shunt
A	0008114	molecular_function	phosphogluconate 2-dehydrogenase activity
A	0009051	biological_process	pentose-phosphate shunt, oxidative branch
A	0016054	biological_process	organic acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019521	biological_process	D-gluconate metabolic process
A	0046177	biological_process	D-gluconate catabolic process
A	0050661	molecular_function	NADP binding
B	0000166	molecular_function	nucleotide binding
B	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
B	0005829	cellular_component	cytosol
B	0006098	biological_process	pentose-phosphate shunt
B	0008114	molecular_function	phosphogluconate 2-dehydrogenase activity
B	0009051	biological_process	pentose-phosphate shunt, oxidative branch
B	0016054	biological_process	organic acid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0019521	biological_process	D-gluconate metabolic process
B	0046177	biological_process	D-gluconate catabolic process
B	0050661	molecular_function	NADP binding
C	0000166	molecular_function	nucleotide binding
C	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
C	0005829	cellular_component	cytosol
C	0006098	biological_process	pentose-phosphate shunt
C	0008114	molecular_function	phosphogluconate 2-dehydrogenase activity
C	0009051	biological_process	pentose-phosphate shunt, oxidative branch
C	0016054	biological_process	organic acid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0019521	biological_process	D-gluconate metabolic process
C	0046177	biological_process	D-gluconate catabolic process
C	0050661	molecular_function	NADP binding
D	0000166	molecular_function	nucleotide binding
D	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
D	0005829	cellular_component	cytosol
D	0006098	biological_process	pentose-phosphate shunt
D	0008114	molecular_function	phosphogluconate 2-dehydrogenase activity
D	0009051	biological_process	pentose-phosphate shunt, oxidative branch
D	0016054	biological_process	organic acid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0019521	biological_process	D-gluconate metabolic process
D	0046177	biological_process	D-gluconate catabolic process
D	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue NAP A 501

Chain	Residue
A	GLY9
A	ALA11
A	ASN32
A	ARG33
A	SER34
A	LYS37
A	GLN74
A	ALA78

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site_id	AC2
Number of Residues	3
Details	binding site for residue NO3 A 502

Chain	Residue
A	ASN149
D	ARG340
A	GLU145

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site_id	AC3
Number of Residues	3
Details	binding site for residue NO3 A 503

Chain	Residue
A	ARG340
D	GLU145
D	ASN149

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site_id	AC4
Number of Residues	7
Details	binding site for residue NAP B 501

Chain	Residue
B	GLY9
B	ASN32
B	ARG33
B	SER34
B	LYS37
B	GLN74
B	ALA78

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site_id	AC5
Number of Residues	4
Details	binding site for residue NO3 B 502

Chain	Residue
B	GLU145
B	ASN149
C	ARG340
C	PRO381

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site_id	AC6
Number of Residues	7
Details	binding site for residue NAP C 501

Chain	Residue
C	ASN32
C	ARG33
C	SER34
C	LYS37
C	VAL73
C	GLN74
C	ALA78

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site_id	AC7
Number of Residues	11
Details	binding site for residue CIT C 502

Chain	Residue
C	ASN101
C	LYS182
C	ASN186
C	GLU189
C	TYR190
C	MET193
C	GLY260
C	THR261
C	ARG286
D	ARG444
D	HIS450

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site_id	AC8
Number of Residues	17
Details	binding site for residue NAP D 501

Chain	Residue
D	GLY9
D	LEU10
D	ALA11
D	MET13
D	ASN32
D	ARG33
D	SER34
D	VAL73
D	GLN74
D	ALA78
D	GLY100
D	ASN101
D	VAL126
D	SER127
D	GLY128
D	GLY129
D	CIT502

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site_id	AC9
Number of Residues	10
Details	binding site for residue CIT D 502

Chain	Residue
C	ARG444
C	PHE447
C	HIS450
D	ASN101
D	GLU189
D	TYR190
D	LYS259
D	THR261
D	ARG286
D	NAP501

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Functional Information from PROSITE/UniProt

site_id	PS00461
Number of Residues	13
Details	6PGD 6-phosphogluconate dehydrogenase signature. IlDtaGQKGTGkW

Chain	Residue	Details
A	ILE252-TRP264

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