7CAP

Cyclic Lys48-linked triubiquitin

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 101

Chain	Residue
A	GLU18
A	HOH267
A	HOH290
C	HOH217

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 102

Chain	Residue
A	HIS68
A	HOH287
A	HOH288
B	HOH280

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN B 101

Chain	Residue
A	HOH237
A	HOH284
B	GLU18
B	HOH279
A	ASP21

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 102

Chain	Residue
B	HIS68
B	HOH281
B	HOH282
B	HOH283

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN C 101

Chain	Residue
C	HIS68
C	HOH259
C	HOH262
C	HOH263

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN C 102

Chain	Residue
B	ASP21
B	HOH230
B	HOH243
B	HOH287
C	GLU18

---

site_id	AC7
Number of Residues	27
Details	binding site for Di-peptide LYS B 48 and GLY C 76

Chain	Residue
A	LYS48
A	ARG54
A	ASP58
A	TYR59
A	GLY75
A	GLY76
A	HOH222
A	HOH255
B	ILE44
B	PHE45
B	ALA46
B	GLY47
B	GLN49
B	LEU50
B	GLY75
B	HOH237
B	HOH271
C	ILE44
C	PHE45
C	ALA46
C	GLY47
C	GLN49
C	LEU50
C	ARG74
C	ARG74
C	GLY75
C	HOH223

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
A	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
A	ARG54
A	ARG72
B	ARG54
B	ARG72
C	ARG54
C	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Essential for function

Chain	Residue	Details
A	HIS68
B	HIS68
C	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
A	SER65
B	SER65
C	SER65

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
A	THR66
B	THR66
C	THR66

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
A	LYS6
B	LYS6
C	LYS6

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY76
B	GLY76
C	GLY76

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
A	LYS11
A	LYS48
B	LYS11
B	LYS48
C	LYS11
C	LYS48

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
A	LYS27
B	LYS27
C	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
A	LYS29
B	LYS29
C	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
A	LYS33
B	LYS33
C	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
A	LYS63
B	LYS63
C	LYS63

---