7CAL

Cryo-EM Structure of the Hyperpolarization-Activated Inwardly Rectifying Potassium Channel KAT1 from Arabidopsis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0042802	molecular_function	identical protein binding
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005242	molecular_function	inward rectifier potassium channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0042802	molecular_function	identical protein binding
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005242	molecular_function	inward rectifier potassium channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0042802	molecular_function	identical protein binding
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005242	molecular_function	inward rectifier potassium channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0042802	molecular_function	identical protein binding
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 3PE A 701

Chain	Residue
A	TRP75
A	GLY286
A	TYR290
B	LEU206
A	LEU175
A	ARG197
A	LYS200
A	SER203
A	VAL204
A	LEU206
A	MET282
A	PHE283

---

site_id	AC2
Number of Residues	16
Details	binding site for Di-peptide 3PE B 701 and LYS B 200

Chain	Residue
B	TRP75
B	SER179
B	ILE196
B	ARG197
B	CYS198
B	THR199
B	LEU201
B	ILE202
B	SER203
B	VAL204
B	LEU206
B	MET282
B	PHE283
B	GLY286
B	TYR290
C	LEU206

---

site_id	AC3
Number of Residues	13
Details	binding site for Di-peptide 3PE C 701 and LYS C 200

Chain	Residue
C	TRP75
C	ILE196
C	ARG197
C	CYS198
C	THR199
C	LEU201
C	ILE202
C	SER203
C	VAL204
C	LEU206
C	PHE283
C	GLY286
C	TYR290

---

site_id	AC4
Number of Residues	16
Details	binding site for Di-peptide 3PE D 701 and LYS D 200

Chain	Residue
D	TRP75
D	SER179
D	ILE196
D	ARG197
D	CYS198
D	THR199
D	LEU201
D	ILE202
D	SER203
D	VAL204
D	LEU206
D	PHE279
D	MET282
D	PHE283
D	GLY286
D	TYR290

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	172
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	140
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	76
Details	Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---