Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7C8Z

Crystal structure of salicylate 5-hydroxylase NagGH (a Rieske non-heme iron-dependent monooxgenase)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0034785	molecular_function	salicylate 5-hydroxylase (NADH) activity
A	0046244	biological_process	salicylic acid catabolic process
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	1902494	cellular_component	catalytic complex
B	0004497	molecular_function	monooxygenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0034785	molecular_function	salicylate 5-hydroxylase (NADH) activity
B	0046244	biological_process	salicylic acid catabolic process
B	1902494	cellular_component	catalytic complex
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0016491	molecular_function	oxidoreductase activity
C	0034785	molecular_function	salicylate 5-hydroxylase (NADH) activity
C	0046244	biological_process	salicylic acid catabolic process
C	0046872	molecular_function	metal ion binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
C	1902494	cellular_component	catalytic complex
D	0004497	molecular_function	monooxygenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0034785	molecular_function	salicylate 5-hydroxylase (NADH) activity
D	0046244	biological_process	salicylic acid catabolic process
D	1902494	cellular_component	catalytic complex
E	0004497	molecular_function	monooxygenase activity
E	0005506	molecular_function	iron ion binding
E	0016491	molecular_function	oxidoreductase activity
E	0034785	molecular_function	salicylate 5-hydroxylase (NADH) activity
E	0046244	biological_process	salicylic acid catabolic process
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	1902494	cellular_component	catalytic complex
F	0004497	molecular_function	monooxygenase activity
F	0016491	molecular_function	oxidoreductase activity
F	0034785	molecular_function	salicylate 5-hydroxylase (NADH) activity
F	0046244	biological_process	salicylic acid catabolic process
F	1902494	cellular_component	catalytic complex
G	0004497	molecular_function	monooxygenase activity
G	0005506	molecular_function	iron ion binding
G	0016491	molecular_function	oxidoreductase activity
G	0034785	molecular_function	salicylate 5-hydroxylase (NADH) activity
G	0046244	biological_process	salicylic acid catabolic process
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	1902494	cellular_component	catalytic complex
H	0004497	molecular_function	monooxygenase activity
H	0016491	molecular_function	oxidoreductase activity
H	0034785	molecular_function	salicylate 5-hydroxylase (NADH) activity
H	0046244	biological_process	salicylic acid catabolic process
H	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FES A 501

Chain	Residue
A	CYS91
A	HIS93
A	ARG94
A	CYS111
A	HIS114

site_id	AC2
Number of Residues	5
Details	binding site for residue FE A 502

Chain	Residue
A	HOH614
A	ASN218
A	HIS224
A	HIS229
A	ASP370

site_id	AC3
Number of Residues	5
Details	binding site for residue FES C 501

Chain	Residue
C	CYS91
C	HIS93
C	ARG94
C	CYS111
C	HIS114

site_id	AC4
Number of Residues	3
Details	binding site for residue FE C 502

Chain	Residue
C	HIS224
C	HIS229
C	ASP370

site_id	AC5
Number of Residues	6
Details	binding site for residue FES E 501

Chain	Residue
E	CYS91
E	HIS93
E	ARG94
E	CYS111
E	HIS114
E	TRP116

site_id	AC6
Number of Residues	3
Details	binding site for residue FE E 502

Chain	Residue
E	HIS224
E	HIS229
E	ASP370

site_id	AC7
Number of Residues	6
Details	binding site for residue FES G 501

Chain	Residue
G	CYS91
G	HIS93
G	ARG94
G	CYS111
G	HIS114
G	TRP116

site_id	AC8
Number of Residues	4
Details	binding site for residue FE G 502

Chain	Residue
G	HIS224
G	HIS229
G	ASP370
G	HOH609

Functional Information from PROSITE/UniProt

site_id	PS00570
Number of Residues	24
Details	RING_HYDROXYL_ALPHA Bacterial ring hydroxylating dioxygenases alpha-subunit signature. CaHRGmrfcrerhGNakdffCpYH

Chain	Residue	Details
A	CYS91-HIS114

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:O85673, ECO:0000255\|PROSITE-ProRule:PRU00628

Chain	Residue	Details
A	CYS91
E	HIS93
E	CYS111
E	HIS114
G	CYS91
G	HIS93
G	CYS111
G	HIS114
A	HIS93
A	CYS111
A	HIS114
C	CYS91
C	HIS93
C	CYS111
C	HIS114
E	CYS91

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:O85673

Chain	Residue	Details
A	HIS224
G	HIS224
G	HIS229
G	ASP370
A	HIS229
A	ASP370
C	HIS224
C	HIS229
C	ASP370
E	HIS224
E	HIS229
E	ASP370

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)