7C8D

Cryo-EM structure of cat ACE2 and SARS-CoV-2 RBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001618	molecular_function	virus receptor activity
A	0002003	biological_process	angiotensin maturation
A	0003051	biological_process	angiotensin-mediated drinking behavior
A	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
A	0004175	molecular_function	endopeptidase activity
A	0004180	molecular_function	carboxypeptidase activity
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008241	molecular_function	peptidyl-dipeptidase activity
A	0009986	cellular_component	cell surface
A	0015827	biological_process	tryptophan transport
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0031526	cellular_component	brush border membrane
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0046718	biological_process	symbiont entry into host cell
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0046872	molecular_function	metal ion binding
A	0050727	biological_process	regulation of inflammatory response
A	0051957	biological_process	positive regulation of amino acid transport
A	0060452	biological_process	positive regulation of cardiac muscle contraction
A	0098670	biological_process	entry receptor-mediated virion attachment to host cell
A	0141109	molecular_function	transporter activator activity
A	1903598	biological_process	positive regulation of gap junction assembly
A	1903779	biological_process	regulation of cardiac conduction
A	1905737	biological_process	positive regulation of L-proline import across plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 801

Chain	Residue
A	HIS374
A	HIS378
A	GLU402

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ

Chain	Residue	Details
A	THR371-GLN380

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
B	ASN343

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355

Chain	Residue	Details
A	GLU375

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355

Chain	Residue	Details
A	HIS505

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355

Chain	Residue	Details
A	ARG169
A	HIS374
A	HIS378
A	GLU402
A	TRP477
A	LYS481

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site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9BYF1

Chain	Residue	Details
A	ARG273
A	HIS345
A	TYR515

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site_id	SWS_FT_FI6
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN53
A	ASN90
A	ASN216
A	ASN299
A	ASN322
A	ASN546
A	ASN660
A	ASN690

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