7C83

Crystal structure of an integral membrane steroid 5-alpha-reductase PbSRD5A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003865	molecular_function	3-oxo-5-alpha-steroid 4-dehydrogenase activity
A	0006629	biological_process	lipid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0016020	cellular_component	membrane
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors

Functional Information from PDB Data

site_id	AC1
Number of Residues	34
Details	binding site for residue NDP A 301

Chain	Residue
A	TYR32
A	ASP163
A	LEU166
A	LEU169
A	ARG170
A	ARG176
A	TYR177
A	GLU178
A	ASN192
A	TYR193
A	GLU196
A	GLY33
A	THR219
A	ASN222
A	LEU223
A	ARG226
A	HIS230
A	TYR234
A	OLC302
A	HOH409
A	HOH410
A	HOH411
A	ARG34
A	HOH433
A	HOH440
A	HOH445
A	HOH446
A	HOH454
A	TRP50
A	ARG90
A	PHE94
A	MET98
A	ARG99
A	ASN159

---

site_id	AC2
Number of Residues	14
Details	binding site for residue OLC A 302

Chain	Residue
A	SER21
A	THR24
A	VAL28
A	TYR32
A	ALA49
A	TRP50
A	GLN53
A	GLU54
A	ALA110
A	PHE116
A	PHE218
A	ASN222
A	NDP301
A	HOH443

---

site_id	AC3
Number of Residues	7
Details	binding site for residue OLC A 303

Chain	Residue
A	GLY81
A	LEU88
A	VAL93
A	LEU160
A	ARG167
A	OLC304
A	OLC309

---

site_id	AC4
Number of Residues	8
Details	binding site for residue OLC A 304

Chain	Residue
A	LEU97
A	ARG99
A	ASP142
A	ARG167
A	ALA171
A	OLC303
A	OLC305
A	HOH420

---

site_id	AC5
Number of Residues	5
Details	binding site for residue OLC A 305

Chain	Residue
A	VAL198
A	TRP208
A	THR209
A	TYR210
A	OLC304

---

site_id	AC6
Number of Residues	1
Details	binding site for residue OLC A 306

Chain	Residue
A	GLY154

---

site_id	AC7
Number of Residues	2
Details	binding site for residue OLC A 307

Chain	Residue
A	LEU48
A	PHE114

---

site_id	AC8
Number of Residues	5
Details	binding site for residue OLC A 308

Chain	Residue
A	ARG47
A	GLY81
A	LEU82
A	LEU140
A	HOH447

---

site_id	AC9
Number of Residues	6
Details	binding site for residue OLC A 309

Chain	Residue
A	TRP156
A	HIS161
A	ALA164
A	ARG168
A	GLU178
A	OLC303

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