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7C7J

Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(G12V,Q63E)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0007165biological_processsignal transduction
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030073biological_processinsulin secretion
A0031045cellular_componentdense core granule
A0032486biological_processRap protein signal transduction
A0033625biological_processpositive regulation of integrin activation
A0035577cellular_componentazurophil granule membrane
A0044877molecular_functionprotein-containing complex binding
A0045121cellular_componentmembrane raft
A0061028biological_processestablishment of endothelial barrier
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0071320biological_processcellular response to cAMP
A0098978cellular_componentglutamatergic synapse
A0099010biological_processmodification of postsynaptic structure
A1901888biological_processregulation of cell junction assembly
A2000114biological_processregulation of establishment of cell polarity
A2000301biological_processnegative regulation of synaptic vesicle exocytosis
B0000166molecular_functionnucleotide binding
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0007165biological_processsignal transduction
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0030073biological_processinsulin secretion
B0031045cellular_componentdense core granule
B0032486biological_processRap protein signal transduction
B0033625biological_processpositive regulation of integrin activation
B0035577cellular_componentazurophil granule membrane
B0044877molecular_functionprotein-containing complex binding
B0045121cellular_componentmembrane raft
B0061028biological_processestablishment of endothelial barrier
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0071320biological_processcellular response to cAMP
B0098978cellular_componentglutamatergic synapse
B0099010biological_processmodification of postsynaptic structure
B1901888biological_processregulation of cell junction assembly
B2000114biological_processregulation of establishment of cell polarity
B2000301biological_processnegative regulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues24
Detailsbinding site for residue GTP A 201
ChainResidue
AGLY13
ALYS31
ATYR32
APRO34
ATHR35
AGLY60
AASN116
ALYS117
AASP119
ALEU120
ASER147
AVAL14
AALA148
ALYS149
AMG203
AHOH313
AHOH317
AGLY15
ALYS16
ASER17
AALA18
APHE28
AVAL29
AGLU30

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 202
ChainResidue
AASN155
AGLU156
AHOH316
AHOH318
BASN155
BGLU156

site_idAC3
Number of Residues4
Detailsbinding site for residue MG A 203
ChainResidue
ASER17
AASP33
ATHR35
AGTP201

site_idAC4
Number of Residues22
Detailsbinding site for residue GTP B 201
ChainResidue
BGLY13
BVAL14
BGLY15
BLYS16
BSER17
BALA18
BPHE28
BVAL29
BGLU30
BLYS31
BTYR32
BPRO34
BTHR35
BGLY60
BASN116
BLYS117
BASP119
BLEU120
BSER147
BALA148
BLYS149
BMG202

site_idAC5
Number of Residues4
Detailsbinding site for residue MG B 202
ChainResidue
BSER17
BASP33
BTHR35
BGTP201

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsRegion: {"description":"Interaction with KRIT1","evidences":[{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues16
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues34
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18309292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"ADP-ribosylserine; by botulinum toxin","evidences":[{"source":"PubMed","id":"3141412","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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