7C77
Cryo-EM structure of mouse TLR3 in complex with UNC93B1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007165 | biological_process | signal transduction |
| B | 0000902 | biological_process | cell morphogenesis |
| B | 0002224 | biological_process | toll-like receptor signaling pathway |
| B | 0002250 | biological_process | adaptive immune response |
| B | 0002376 | biological_process | immune system process |
| B | 0002457 | biological_process | T cell antigen processing and presentation |
| B | 0005515 | molecular_function | protein binding |
| B | 0005764 | cellular_component | lysosome |
| B | 0005768 | cellular_component | endosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0019882 | biological_process | antigen processing and presentation |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0032009 | cellular_component | early phagosome |
| B | 0032735 | biological_process | positive regulation of interleukin-12 production |
| B | 0032755 | biological_process | positive regulation of interleukin-6 production |
| B | 0034138 | biological_process | toll-like receptor 3 signaling pathway |
| B | 0034154 | biological_process | toll-like receptor 7 signaling pathway |
| B | 0034162 | biological_process | toll-like receptor 9 signaling pathway |
| B | 0035325 | molecular_function | Toll-like receptor binding |
| B | 0045087 | biological_process | innate immune response |
| B | 0045335 | cellular_component | phagocytic vesicle |
| B | 0051607 | biological_process | defense response to virus |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"LRR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 20 |
| Details | Repeat: {"description":"LRR 17"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 19"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 20"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 21"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 22"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 53 |
| Details | Domain: {"description":"LRRCT"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 7 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 11 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18420935","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
