7C76
Cryo-EM structure of human TLR3 in complex with UNC93B1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002224 | biological_process | toll-like receptor signaling pathway |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0006955 | biological_process | immune response |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000902 | biological_process | cell morphogenesis |
| B | 0002224 | biological_process | toll-like receptor signaling pathway |
| B | 0002250 | biological_process | adaptive immune response |
| B | 0002376 | biological_process | immune system process |
| B | 0002457 | biological_process | T cell antigen processing and presentation |
| B | 0005515 | molecular_function | protein binding |
| B | 0005764 | cellular_component | lysosome |
| B | 0005768 | cellular_component | endosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0019882 | biological_process | antigen processing and presentation |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0032009 | cellular_component | early phagosome |
| B | 0032735 | biological_process | positive regulation of interleukin-12 production |
| B | 0032755 | biological_process | positive regulation of interleukin-6 production |
| B | 0034138 | biological_process | toll-like receptor 3 signaling pathway |
| B | 0034154 | biological_process | toll-like receptor 7 signaling pathway |
| B | 0034162 | biological_process | toll-like receptor 9 signaling pathway |
| B | 0035325 | molecular_function | Toll-like receptor binding |
| B | 0045087 | biological_process | innate immune response |
| B | 0045335 | cellular_component | phagocytic vesicle |
| B | 0051607 | biological_process | defense response to virus |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL64-MET84 | |
| B | VAL428-LEU448 | |
| B | PHE469-SER489 | |
| B | LEU491-TYR511 | |
| B | LYS110-ILE130 | |
| B | PHE132-THR152 | |
| B | THR160-GLY180 | |
| B | ILE223-LEU243 | |
| B | LEU285-GLY305 | |
| B | LEU343-LEU363 | |
| B | LEU378-TRP398 | |
| B | VAL403-ALA423 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER547 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER550 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN251 | |
| B | ASN272 | |
| B | ASN449 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22579623 |
| Chain | Residue | Details |
| A | ASN52 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN57 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:22579623 |
| Chain | Residue | Details |
| A | ASN70 | |
| A | ASN265 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15961631, ECO:0000269|PubMed:22579623 |
| Chain | Residue | Details |
| A | ASN124 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16043704 |
| Chain | Residue | Details |
| A | ASN196 | |
| A | ASN636 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22579623 |
| Chain | Residue | Details |
| A | ASN247 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15961631, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:22579623 |
| Chain | Residue | Details |
| A | ASN252 | |
| A | ASN275 | |
| A | ASN291 | |
| A | ASN398 | |
| A | ASN413 | |
| A | ASN507 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN662 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:37158982 |
| Chain | Residue | Details |
| A | LYS765 | |
| A | LYS812 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32878999 |
| Chain | Residue | Details |
| A | LYS831 |
