Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7C4J

Cryo-EM structure of the yeast Swi/Snf complex in a nucleosome free state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016514	cellular_component	SWI/SNF complex
A	0030527	molecular_function	structural constituent of chromatin
A	0034198	biological_process	cellular response to amino acid starvation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0000436	biological_process	carbon catabolite activation of transcription from RNA polymerase II promoter
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005829	cellular_component	cytosol
B	0006338	biological_process	chromatin remodeling
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016514	cellular_component	SWI/SNF complex
B	0031496	biological_process	positive regulation of mating type switching
B	0042393	molecular_function	histone binding
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0000182	molecular_function	rDNA binding
C	0000470	biological_process	maturation of LSU-rRNA
C	0000785	cellular_component	chromatin
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006289	biological_process	nucleotide-excision repair
C	0006338	biological_process	chromatin remodeling
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016514	cellular_component	SWI/SNF complex
C	0045943	biological_process	positive regulation of transcription by RNA polymerase I
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0000436	biological_process	carbon catabolite activation of transcription from RNA polymerase II promoter
D	0000785	cellular_component	chromatin
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016514	cellular_component	SWI/SNF complex
D	0031496	biological_process	positive regulation of mating type switching
D	0042393	molecular_function	histone binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0000785	cellular_component	chromatin
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005829	cellular_component	cytosol
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0016514	cellular_component	SWI/SNF complex
E	0016586	cellular_component	RSC-type complex
E	0031490	molecular_function	chromatin DNA binding
F	0000228	cellular_component	nuclear chromosome
F	0000436	biological_process	carbon catabolite activation of transcription from RNA polymerase II promoter
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0000785	cellular_component	chromatin
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0006338	biological_process	chromatin remodeling
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016514	cellular_component	SWI/SNF complex
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
H	0000182	molecular_function	rDNA binding
H	0000785	cellular_component	chromatin
H	0003677	molecular_function	DNA binding
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0006261	biological_process	DNA-templated DNA replication
H	0006302	biological_process	double-strand break repair
H	0006338	biological_process	chromatin remodeling
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0008094	molecular_function	ATP-dependent activity, acting on DNA
H	0016514	cellular_component	SWI/SNF complex
H	0016787	molecular_function	hydrolase activity
H	0031492	molecular_function	nucleosomal DNA binding
H	0031496	biological_process	positive regulation of mating type switching
H	0034198	biological_process	cellular response to amino acid starvation
H	0035973	biological_process	aggrephagy
H	0042148	biological_process	DNA strand invasion
H	0042393	molecular_function	histone binding
H	0045815	biological_process	transcription initiation-coupled chromatin remodeling
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0070577	molecular_function	lysine-acetylated histone binding
H	0140566	molecular_function	histone reader activity
H	0140658	molecular_function	ATP-dependent chromatin remodeler activity
H	1900189	biological_process	positive regulation of cell adhesion involved in single-species biofilm formation
H	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
I	0000436	biological_process	carbon catabolite activation of transcription from RNA polymerase II promoter
I	0000785	cellular_component	chromatin
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0003677	molecular_function	DNA binding
I	0005634	cellular_component	nucleus
I	0006261	biological_process	DNA-templated DNA replication
I	0006338	biological_process	chromatin remodeling
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0008270	molecular_function	zinc ion binding
I	0016514	cellular_component	SWI/SNF complex
I	0031496	biological_process	positive regulation of mating type switching
I	0034198	biological_process	cellular response to amino acid starvation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046872	molecular_function	metal ion binding
I	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
J	0000785	cellular_component	chromatin
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0006337	biological_process	nucleosome disassembly
J	0006338	biological_process	chromatin remodeling
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0007059	biological_process	chromosome segregation
J	0015616	molecular_function	DNA translocase activity
J	0016514	cellular_component	SWI/SNF complex
J	0016586	cellular_component	RSC-type complex
K	0000785	cellular_component	chromatin
K	0003674	molecular_function	molecular_function
K	0003682	molecular_function	chromatin binding
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0006325	biological_process	chromatin organization
K	0006337	biological_process	nucleosome disassembly
K	0006338	biological_process	chromatin remodeling
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0016514	cellular_component	SWI/SNF complex
K	0016586	cellular_component	RSC-type complex
K	0035267	cellular_component	NuA4 histone acetyltransferase complex
K	0043232	cellular_component	intracellular non-membrane-bounded organelle
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0000785	cellular_component	chromatin
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0006325	biological_process	chromatin organization
L	0006337	biological_process	nucleosome disassembly
L	0006338	biological_process	chromatin remodeling
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0016514	cellular_component	SWI/SNF complex
L	0016586	cellular_component	RSC-type complex
L	0043232	cellular_component	intracellular non-membrane-bounded organelle
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SdiFlskpSkalyp..DYYmiIkypVafdnInthietla..Ynslketlqdfhl.IfsNAriY

Chain	Residue	Details
H	SER1573-TYR1630

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19779198

Chain	Residue	Details
J	SER77
B	SER185
B	SER657
D	SER88
D	SER185
D	SER657

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
J	SER122
D	THR235

site_id	SWS_FT_FI3
Number of Residues	10
Details	DNA_BIND: A.T hook 3

Chain	Residue	Details
H	GLY1516-LYS1526

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00541

Chain	Residue	Details
H	ASP792

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
H	SER358

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:19779198

Chain	Residue	Details
H	THR383

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
H	SER716

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956

Chain	Residue	Details
H	SER1340

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744\|PubMed:22106047

Chain	Residue	Details
H	LYS543

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)