7C49
nicA2 with cofactor FAD and substrate nicotine
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 40 |
| Details | binding site for residue FAD A 1001 |
| Chain | Residue |
| A | VAL59 |
| A | ARG85 |
| A | GLY89 |
| A | GLY90 |
| A | ARG91 |
| A | THR92 |
| A | PHE104 |
| A | GLY105 |
| A | GLY106 |
| A | ALA107 |
| A | TRP108 |
| A | GLY60 |
| A | PRO278 |
| A | VAL279 |
| A | THR307 |
| A | VAL308 |
| A | PRO309 |
| A | TRP417 |
| A | PHE422 |
| A | ALA426 |
| A | TRP427 |
| A | GLY452 |
| A | GLY61 |
| A | ALA453 |
| A | ALA461 |
| A | ASN462 |
| A | ILE463 |
| A | ALA466 |
| A | HNL1002 |
| A | HOH1109 |
| A | HOH1110 |
| A | HOH1123 |
| A | HOH1149 |
| A | GLY62 |
| A | HOH1152 |
| A | PHE63 |
| A | ALA64 |
| A | LEU82 |
| A | GLU83 |
| A | ALA84 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue HNL A 1002 |
| Chain | Residue |
| A | LEU217 |
| A | THR250 |
| A | THR381 |
| A | TRP427 |
| A | ALA461 |
| A | FAD1001 |
| site_id | AC3 |
| Number of Residues | 38 |
| Details | binding site for residue FAD B 1001 |
| Chain | Residue |
| B | VAL59 |
| B | GLY60 |
| B | GLY62 |
| B | PHE63 |
| B | ALA64 |
| B | GLU83 |
| B | ALA84 |
| B | ARG85 |
| B | GLY89 |
| B | GLY90 |
| B | ARG91 |
| B | THR92 |
| B | PHE104 |
| B | GLY105 |
| B | GLY106 |
| B | ALA107 |
| B | TRP108 |
| B | PRO278 |
| B | VAL279 |
| B | THR307 |
| B | VAL308 |
| B | PRO309 |
| B | TRP417 |
| B | PHE422 |
| B | ALA426 |
| B | TRP427 |
| B | ALA461 |
| B | ASN462 |
| B | ILE463 |
| B | ALA466 |
| B | HNL1002 |
| B | HOH1101 |
| B | HOH1117 |
| B | HOH1124 |
| B | HOH1146 |
| B | HOH1148 |
| B | HOH1154 |
| B | HOH1155 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue HNL B 1002 |
| Chain | Residue |
| B | LEU217 |
| B | TYR218 |
| B | THR250 |
| B | TRP364 |
| B | THR381 |
| B | TRP427 |
| B | ALA461 |
| B | FAD1001 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:29812904, ECO:0000269|PubMed:32873764, ECO:0000269|PubMed:33464876, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:6C71, ECO:0007744|PDB:7C49, ECO:0007744|PDB:7C4A, ECO:0007744|PDB:7KHN, ECO:0007744|PDB:7KHO |
| Chain | Residue | Details |
| A | ALA64 | |
| A | GLU83 | |
| A | ARG91 | |
| A | VAL279 | |
| A | ALA453 | |
| A | ILE463 | |
| B | ALA64 | |
| B | GLU83 | |
| B | ARG91 | |
| B | VAL279 | |
| B | ALA453 | |
| B | ILE463 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:33464876, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:7KHN |
| Chain | Residue | Details |
| A | ALA84 | |
| B | ALA84 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:32873764, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:7C49, ECO:0007744|PDB:7C4A |
| Chain | Residue | Details |
| A | ARG85 | |
| B | ARG85 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:29812904, ECO:0000269|PubMed:32873764, ECO:0000269|PubMed:33464876, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:6C71, ECO:0007744|PDB:7C4A, ECO:0007744|PDB:7KHN, ECO:0007744|PDB:7KHO |
| Chain | Residue | Details |
| A | TRP108 | |
| B | TRP108 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29812904, ECO:0000269|PubMed:33464876, ECO:0007744|PDB:6C71, ECO:0007744|PDB:7C49, ECO:0007744|PDB:7KHN, ECO:0007744|PDB:7KHO |
| Chain | Residue | Details |
| A | THR381 | |
| B | THR381 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27933790, ECO:0000269|PubMed:29812904, ECO:0000269|PubMed:32873764, ECO:0007744|PDB:5TTJ, ECO:0007744|PDB:5TTK, ECO:0007744|PDB:6C71, ECO:0007744|PDB:7C49 |
| Chain | Residue | Details |
| A | ASN462 | |
| B | ASN462 |
