7C49

nicA2 with cofactor FAD and substrate nicotine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	40
Details	binding site for residue FAD A 1001

Chain	Residue
A	VAL59
A	ARG85
A	GLY89
A	GLY90
A	ARG91
A	THR92
A	PHE104
A	GLY105
A	GLY106
A	ALA107
A	TRP108
A	GLY60
A	PRO278
A	VAL279
A	THR307
A	VAL308
A	PRO309
A	TRP417
A	PHE422
A	ALA426
A	TRP427
A	GLY452
A	GLY61
A	ALA453
A	ALA461
A	ASN462
A	ILE463
A	ALA466
A	HNL1002
A	HOH1109
A	HOH1110
A	HOH1123
A	HOH1149
A	GLY62
A	HOH1152
A	PHE63
A	ALA64
A	LEU82
A	GLU83
A	ALA84

---

site_id	AC2
Number of Residues	6
Details	binding site for residue HNL A 1002

Chain	Residue
A	LEU217
A	THR250
A	THR381
A	TRP427
A	ALA461
A	FAD1001

---

site_id	AC3
Number of Residues	38
Details	binding site for residue FAD B 1001

Chain	Residue
B	VAL59
B	GLY60
B	GLY62
B	PHE63
B	ALA64
B	GLU83
B	ALA84
B	ARG85
B	GLY89
B	GLY90
B	ARG91
B	THR92
B	PHE104
B	GLY105
B	GLY106
B	ALA107
B	TRP108
B	PRO278
B	VAL279
B	THR307
B	VAL308
B	PRO309
B	TRP417
B	PHE422
B	ALA426
B	TRP427
B	ALA461
B	ASN462
B	ILE463
B	ALA466
B	HNL1002
B	HOH1101
B	HOH1117
B	HOH1124
B	HOH1146
B	HOH1148
B	HOH1154
B	HOH1155

---

site_id	AC4
Number of Residues	8
Details	binding site for residue HNL B 1002

Chain	Residue
B	LEU217
B	TYR218
B	THR250
B	TRP364
B	THR381
B	TRP427
B	ALA461
B	FAD1001

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29812904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32873764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33464876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33464876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32873764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C4A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29812904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32873764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33464876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29812904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33464876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27933790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29812904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32873764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C49","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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