7C2O
Crystal structure of the R-specific Carbonyl Reductase from Candida parapsilosis ATCC 7330 without DTT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0006066 | biological_process | alcohol metabolic process |
| A | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0006066 | biological_process | alcohol metabolic process |
| B | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS102 |
| A | CYS105 |
| A | CYS108 |
| A | CYS116 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | binding site for residue NDP A 402 |
| Chain | Residue |
| A | THR171 |
| A | GLY193 |
| A | ILE194 |
| A | GLY195 |
| A | GLY196 |
| A | LEU197 |
| A | SER216 |
| A | ARG217 |
| A | LYS221 |
| A | CYS256 |
| A | ALA257 |
| A | SER258 |
| A | GLY259 |
| A | ILE260 |
| A | ASP261 |
| A | VAL281 |
| A | GLY282 |
| A | LEU283 |
| A | SER307 |
| A | LEU308 |
| A | LEU309 |
| A | ARG356 |
| A | HOH503 |
| A | HOH514 |
| A | HOH518 |
| A | CYS48 |
| A | TYR49 |
| A | SER50 |
| A | TRP59 |
| A | CYS167 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EPE B 401 |
| Chain | Residue |
| B | TYR49 |
| B | GLY195 |
| B | GLY196 |
| B | LEU197 |
| B | ALA257 |
| B | HOH506 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 402 |
| Chain | Residue |
| B | CYS102 |
| B | CYS105 |
| B | CYS108 |
| B | CYS116 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 403 |
| Chain | Residue |
| B | CYS48 |
| B | SER50 |
| B | HIS71 |
| B | CYS167 |
Functional Information from PROSITE/UniProt
| site_id | PS00059 |
| Number of Residues | 15 |
| Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEiIGEviavGdeV |
| Chain | Residue | Details |
| A | GLY70-VAL84 |
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VGIIGiGGLGhlalqfanamgan.VTaFS |
| Chain | Residue | Details |
| A | VAL189-SER216 |
