7BYN

Cryo-EM structure of human KCNQ4 with linopirdine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0007605	biological_process	sensory perception of sound
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008218	biological_process	bioluminescence
A	0009925	cellular_component	basal plasma membrane
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0042472	biological_process	inner ear morphogenesis
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000922	cellular_component	spindle pole
B	0001975	biological_process	response to amphetamine
B	0002027	biological_process	regulation of heart rate
B	0005246	molecular_function	calcium channel regulator activity
B	0005509	molecular_function	calcium ion binding
B	0005513	biological_process	detection of calcium ion
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005856	cellular_component	cytoskeleton
B	0005876	cellular_component	spindle microtubule
B	0005886	cellular_component	plasma membrane
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0008179	molecular_function	adenylate cyclase binding
B	0010856	molecular_function	adenylate cyclase activator activity
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0019901	molecular_function	protein kinase binding
B	0019904	molecular_function	protein domain specific binding
B	0021762	biological_process	substantia nigra development
B	0030017	cellular_component	sarcomere
B	0030235	molecular_function	nitric-oxide synthase regulator activity
B	0030426	cellular_component	growth cone
B	0030672	cellular_component	synaptic vesicle membrane
B	0031432	molecular_function	titin binding
B	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
B	0031966	cellular_component	mitochondrial membrane
B	0031982	cellular_component	vesicle
B	0032465	biological_process	regulation of cytokinesis
B	0032991	cellular_component	protein-containing complex
B	0034704	cellular_component	calcium channel complex
B	0043209	cellular_component	myelin sheath
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0043548	molecular_function	phosphatidylinositol 3-kinase binding
B	0044305	cellular_component	calyx of Held
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0050998	molecular_function	nitric-oxide synthase binding
B	0051412	biological_process	response to corticosterone
B	0051592	biological_process	response to calcium ion
B	0055117	biological_process	regulation of cardiac muscle contraction
B	0060291	biological_process	long-term synaptic potentiation
B	0072542	molecular_function	protein phosphatase activator activity
B	0090150	biological_process	establishment of protein localization to membrane
B	0090151	biological_process	establishment of protein localization to mitochondrial membrane
B	0097225	cellular_component	sperm midpiece
B	0097720	biological_process	calcineurin-mediated signaling
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098901	biological_process	regulation of cardiac muscle cell action potential
B	0099523	cellular_component	presynaptic cytosol
B	0099524	cellular_component	postsynaptic cytosol
B	0140238	biological_process	presynaptic endocytosis
B	0141110	molecular_function	transporter inhibitor activity
B	1900242	biological_process	regulation of synaptic vesicle endocytosis
B	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
B	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
B	1902494	cellular_component	catalytic complex
B	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
B	2000300	biological_process	regulation of synaptic vesicle exocytosis
C	0005216	molecular_function	monoatomic ion channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005267	molecular_function	potassium channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006091	biological_process	generation of precursor metabolites and energy
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0007605	biological_process	sensory perception of sound
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008218	biological_process	bioluminescence
C	0009925	cellular_component	basal plasma membrane
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0042472	biological_process	inner ear morphogenesis
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
D	0000086	biological_process	G2/M transition of mitotic cell cycle
D	0000922	cellular_component	spindle pole
D	0001975	biological_process	response to amphetamine
D	0002027	biological_process	regulation of heart rate
D	0005246	molecular_function	calcium channel regulator activity
D	0005509	molecular_function	calcium ion binding
D	0005513	biological_process	detection of calcium ion
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005856	cellular_component	cytoskeleton
D	0005876	cellular_component	spindle microtubule
D	0005886	cellular_component	plasma membrane
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0008179	molecular_function	adenylate cyclase binding
D	0010856	molecular_function	adenylate cyclase activator activity
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0016020	cellular_component	membrane
D	0019901	molecular_function	protein kinase binding
D	0019904	molecular_function	protein domain specific binding
D	0021762	biological_process	substantia nigra development
D	0030017	cellular_component	sarcomere
D	0030235	molecular_function	nitric-oxide synthase regulator activity
D	0030426	cellular_component	growth cone
D	0030672	cellular_component	synaptic vesicle membrane
D	0031432	molecular_function	titin binding
D	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
D	0031966	cellular_component	mitochondrial membrane
D	0031982	cellular_component	vesicle
D	0032465	biological_process	regulation of cytokinesis
D	0032991	cellular_component	protein-containing complex
D	0034704	cellular_component	calcium channel complex
D	0043209	cellular_component	myelin sheath
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0043548	molecular_function	phosphatidylinositol 3-kinase binding
D	0044305	cellular_component	calyx of Held
D	0044325	molecular_function	transmembrane transporter binding
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0050998	molecular_function	nitric-oxide synthase binding
D	0051412	biological_process	response to corticosterone
D	0051592	biological_process	response to calcium ion
D	0055117	biological_process	regulation of cardiac muscle contraction
D	0060291	biological_process	long-term synaptic potentiation
D	0072542	molecular_function	protein phosphatase activator activity
D	0090150	biological_process	establishment of protein localization to membrane
D	0090151	biological_process	establishment of protein localization to mitochondrial membrane
D	0097225	cellular_component	sperm midpiece
D	0097720	biological_process	calcineurin-mediated signaling
D	0098685	cellular_component	Schaffer collateral - CA1 synapse
D	0098901	biological_process	regulation of cardiac muscle cell action potential
D	0099523	cellular_component	presynaptic cytosol
D	0099524	cellular_component	postsynaptic cytosol
D	0140238	biological_process	presynaptic endocytosis
D	0141110	molecular_function	transporter inhibitor activity
D	1900242	biological_process	regulation of synaptic vesicle endocytosis
D	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
D	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
D	1902494	cellular_component	catalytic complex
D	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
D	2000300	biological_process	regulation of synaptic vesicle exocytosis
E	0005216	molecular_function	monoatomic ion channel activity
E	0005249	molecular_function	voltage-gated potassium channel activity
E	0005267	molecular_function	potassium channel activity
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0006091	biological_process	generation of precursor metabolites and energy
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0007605	biological_process	sensory perception of sound
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0008218	biological_process	bioluminescence
E	0009925	cellular_component	basal plasma membrane
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034702	cellular_component	monoatomic ion channel complex
E	0042472	biological_process	inner ear morphogenesis
E	0055085	biological_process	transmembrane transport
E	0071805	biological_process	potassium ion transmembrane transport
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0001975	biological_process	response to amphetamine
F	0002027	biological_process	regulation of heart rate
F	0005246	molecular_function	calcium channel regulator activity
F	0005509	molecular_function	calcium ion binding
F	0005513	biological_process	detection of calcium ion
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005856	cellular_component	cytoskeleton
F	0005876	cellular_component	spindle microtubule
F	0005886	cellular_component	plasma membrane
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0008179	molecular_function	adenylate cyclase binding
F	0010856	molecular_function	adenylate cyclase activator activity
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0019901	molecular_function	protein kinase binding
F	0019904	molecular_function	protein domain specific binding
F	0021762	biological_process	substantia nigra development
F	0030017	cellular_component	sarcomere
F	0030235	molecular_function	nitric-oxide synthase regulator activity
F	0030426	cellular_component	growth cone
F	0030672	cellular_component	synaptic vesicle membrane
F	0031432	molecular_function	titin binding
F	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
F	0031966	cellular_component	mitochondrial membrane
F	0031982	cellular_component	vesicle
F	0032465	biological_process	regulation of cytokinesis
F	0032991	cellular_component	protein-containing complex
F	0034704	cellular_component	calcium channel complex
F	0043209	cellular_component	myelin sheath
F	0043539	molecular_function	protein serine/threonine kinase activator activity
F	0043548	molecular_function	phosphatidylinositol 3-kinase binding
F	0044305	cellular_component	calyx of Held
F	0044325	molecular_function	transmembrane transporter binding
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050848	biological_process	regulation of calcium-mediated signaling
F	0050998	molecular_function	nitric-oxide synthase binding
F	0051412	biological_process	response to corticosterone
F	0051592	biological_process	response to calcium ion
F	0055117	biological_process	regulation of cardiac muscle contraction
F	0060291	biological_process	long-term synaptic potentiation
F	0072542	molecular_function	protein phosphatase activator activity
F	0090150	biological_process	establishment of protein localization to membrane
F	0090151	biological_process	establishment of protein localization to mitochondrial membrane
F	0097225	cellular_component	sperm midpiece
F	0097720	biological_process	calcineurin-mediated signaling
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098901	biological_process	regulation of cardiac muscle cell action potential
F	0099523	cellular_component	presynaptic cytosol
F	0099524	cellular_component	postsynaptic cytosol
F	0140238	biological_process	presynaptic endocytosis
F	0141110	molecular_function	transporter inhibitor activity
F	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
F	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
F	1902494	cellular_component	catalytic complex
F	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
F	2000300	biological_process	regulation of synaptic vesicle exocytosis
G	0005216	molecular_function	monoatomic ion channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005267	molecular_function	potassium channel activity
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0006091	biological_process	generation of precursor metabolites and energy
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0007605	biological_process	sensory perception of sound
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0008218	biological_process	bioluminescence
G	0009925	cellular_component	basal plasma membrane
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034702	cellular_component	monoatomic ion channel complex
G	0042472	biological_process	inner ear morphogenesis
G	0055085	biological_process	transmembrane transport
G	0071805	biological_process	potassium ion transmembrane transport
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0001975	biological_process	response to amphetamine
H	0002027	biological_process	regulation of heart rate
H	0005246	molecular_function	calcium channel regulator activity
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005856	cellular_component	cytoskeleton
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0008179	molecular_function	adenylate cyclase binding
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0019901	molecular_function	protein kinase binding
H	0019904	molecular_function	protein domain specific binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0030235	molecular_function	nitric-oxide synthase regulator activity
H	0030426	cellular_component	growth cone
H	0030672	cellular_component	synaptic vesicle membrane
H	0031432	molecular_function	titin binding
H	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
H	0031966	cellular_component	mitochondrial membrane
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0043548	molecular_function	phosphatidylinositol 3-kinase binding
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0050998	molecular_function	nitric-oxide synthase binding
H	0051412	biological_process	response to corticosterone
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060291	biological_process	long-term synaptic potentiation
H	0072542	molecular_function	protein phosphatase activator activity
H	0090150	biological_process	establishment of protein localization to membrane
H	0090151	biological_process	establishment of protein localization to mitochondrial membrane
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0099524	cellular_component	postsynaptic cytosol
H	0140238	biological_process	presynaptic endocytosis
H	0141110	molecular_function	transporter inhibitor activity
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
H	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue PT5 A 701

Chain	Residue
A	LEU91
A	GLU92
A	PRO94
A	PHE99
A	HIS102
A	ARG150
A	PHE174
A	ARG216
A	MET217

---

site_id	AC2
Number of Residues	9
Details	binding site for residue K A 702

Chain	Residue
A	THR283
A	ILE284
A	K704
C	THR283
C	ILE284
E	THR283
E	ILE284
G	THR283
G	ILE284

---

site_id	AC3
Number of Residues	8
Details	binding site for residue K A 703

Chain	Residue
A	GLY285
A	TYR286
C	GLY285
C	TYR286
E	GLY285
E	TYR286
G	GLY285
G	TYR286

---

site_id	AC4
Number of Residues	5
Details	binding site for residue K A 704

Chain	Residue
A	THR283
A	K702
C	THR283
E	THR283
G	THR283

---

site_id	AC5
Number of Residues	10
Details	binding site for residue PT5 C 701

Chain	Residue
C	GLU92
C	PRO94
C	PHE99
C	HIS102
C	VAL103
C	ARG150
C	PHE174
C	ARG216
C	MET217
C	ARG219

---

site_id	AC6
Number of Residues	3
Details	binding site for residue FCC C 702

Chain	Residue
C	ARG331
E	ARG331
G	ARG331

---

site_id	AC7
Number of Residues	10
Details	binding site for residue PT5 E 701

Chain	Residue
E	GLU92
E	PRO94
E	PHE99
E	HIS102
E	VAL103
E	ARG150
E	PHE174
E	ARG216
E	MET217
E	ARG219

---

site_id	AC8
Number of Residues	10
Details	binding site for residue PT5 G 701

Chain	Residue
G	GLU92
G	PRO94
G	PHE99
G	HIS102
G	VAL103
G	ARG150
G	PHE174
G	ARG216
G	MET217
G	ARG219

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
B	ASP20-LEU32
B	ASP56-PHE68
B	ASP93-LEU105
B	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	88
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	104
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	84
Details	Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	36
Details	Region: {"description":"Interaction with CALM","evidences":[{"source":"PubMed","id":"29429937","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	56
Details	Region: {"description":"Interaction with CALM","evidences":[{"source":"UniProtKB","id":"P51787","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"34767770","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VNP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	80
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP31","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---