Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002039 | molecular_function | p53 binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0002039 | molecular_function | p53 binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0042054 | molecular_function | histone methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1501 |
| Chain | Residue |
| A | CYS980 |
| A | CYS1017 |
| A | CYS1023 |
| A | CYS1027 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1502 |
| Chain | Residue |
| A | CYS974 |
| A | CYS987 |
| A | CYS1017 |
| A | CYS1021 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1503 |
| Chain | Residue |
| A | CYS976 |
| A | CYS980 |
| A | CYS985 |
| A | CYS974 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1504 |
| Chain | Residue |
| A | CYS1115 |
| A | CYS1168 |
| A | CYS1170 |
| A | CYS1175 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue SAM A 1505 |
| Chain | Residue |
| A | MET1048 |
| A | TRP1050 |
| A | SER1084 |
| A | TYR1085 |
| A | ARG1109 |
| A | PHE1110 |
| A | ASN1112 |
| A | HIS1113 |
| A | TYR1154 |
| A | PHE1158 |
| A | PHE1166 |
| A | THR1167 |
| A | CYS1168 |
| A | GLN1169 |
| A | N471506 |
| A | HOH1652 |
| A | HOH1677 |
| A | HOH1686 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue N47 A 1506 |
| Chain | Residue |
| A | TYR1067 |
| A | ALA1077 |
| A | ASP1078 |
| A | ASP1083 |
| A | SER1084 |
| A | LEU1086 |
| A | ASP1088 |
| A | VAL1096 |
| A | CYS1098 |
| A | TYR1154 |
| A | ARG1157 |
| A | PHE1158 |
| A | SAM1505 |
| A | HOH1641 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1501 |
| Chain | Residue |
| B | CYS980 |
| B | CYS1017 |
| B | CYS1023 |
| B | CYS1027 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 1502 |
| Chain | Residue |
| B | CYS974 |
| B | CYS987 |
| B | CYS1017 |
| B | CYS1021 |
| B | ZN1503 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 1503 |
| Chain | Residue |
| B | CYS974 |
| B | CYS976 |
| B | CYS980 |
| B | CYS985 |
| B | ZN1502 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1504 |
| Chain | Residue |
| B | CYS1115 |
| B | CYS1168 |
| B | CYS1170 |
| B | CYS1175 |
| site_id | AD2 |
| Number of Residues | 20 |
| Details | binding site for residue SAM B 1505 |
| Chain | Residue |
| B | MET1048 |
| B | TRP1050 |
| B | SER1084 |
| B | TYR1085 |
| B | ARG1109 |
| B | PHE1110 |
| B | ASN1112 |
| B | HIS1113 |
| B | TYR1154 |
| B | PHE1158 |
| B | PHE1166 |
| B | THR1167 |
| B | CYS1168 |
| B | GLN1169 |
| B | N471506 |
| B | HOH1642 |
| B | HOH1725 |
| B | HOH1727 |
| B | HOH1744 |
| B | HOH1756 |
| site_id | AD3 |
| Number of Residues | 14 |
| Details | binding site for residue N47 B 1506 |
| Chain | Residue |
| B | HOH1653 |
| B | TYR1067 |
| B | ASP1074 |
| B | ALA1077 |
| B | ASP1078 |
| B | ASP1083 |
| B | SER1084 |
| B | LEU1086 |
| B | ASP1088 |
| B | CYS1098 |
| B | TYR1154 |
| B | ARG1157 |
| B | PHE1158 |
| B | SAM1505 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 126 |
| Details | Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Domain: {"description":"Post-SET"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"Interaction with histone H3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Histone H3K9me binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
