7BTI
Phalloidin bound F-actin complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001725 | cellular_component | stress fiber |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005865 | cellular_component | striated muscle thin filament |
| A | 0005884 | cellular_component | actin filament |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030240 | biological_process | skeletal muscle thin filament assembly |
| A | 0048741 | biological_process | skeletal muscle fiber development |
| B | 0001725 | cellular_component | stress fiber |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005865 | cellular_component | striated muscle thin filament |
| B | 0005884 | cellular_component | actin filament |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030240 | biological_process | skeletal muscle thin filament assembly |
| B | 0048741 | biological_process | skeletal muscle fiber development |
| C | 0001725 | cellular_component | stress fiber |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005865 | cellular_component | striated muscle thin filament |
| C | 0005884 | cellular_component | actin filament |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030240 | biological_process | skeletal muscle thin filament assembly |
| C | 0048741 | biological_process | skeletal muscle fiber development |
| D | 0001725 | cellular_component | stress fiber |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005865 | cellular_component | striated muscle thin filament |
| D | 0005884 | cellular_component | actin filament |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0030240 | biological_process | skeletal muscle thin filament assembly |
| D | 0048741 | biological_process | skeletal muscle fiber development |
| E | 0001725 | cellular_component | stress fiber |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0005865 | cellular_component | striated muscle thin filament |
| E | 0005884 | cellular_component | actin filament |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0030240 | biological_process | skeletal muscle thin filament assembly |
| E | 0048741 | biological_process | skeletal muscle fiber development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | ASP154 |
| A | ADP402 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue ADP A 402 |
| Chain | Residue |
| A | GLU214 |
| A | GLY301 |
| A | GLY302 |
| A | TYR306 |
| A | LYS336 |
| A | MG401 |
| A | GLY13 |
| A | SER14 |
| A | GLY15 |
| A | LEU16 |
| A | LYS18 |
| A | GLY156 |
| A | ASP157 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | GLN137 |
| B | ASP154 |
| B | ADP402 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue ADP B 402 |
| Chain | Residue |
| B | GLY13 |
| B | SER14 |
| B | GLY15 |
| B | LEU16 |
| B | LYS18 |
| B | GLY156 |
| B | ASP157 |
| B | LYS213 |
| B | GLU214 |
| B | GLY301 |
| B | GLY302 |
| B | MET305 |
| B | TYR306 |
| B | LYS336 |
| B | MG401 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 401 |
| Chain | Residue |
| C | GLN137 |
| C | ADP402 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue ADP C 402 |
| Chain | Residue |
| C | GLY13 |
| C | SER14 |
| C | LEU16 |
| C | LYS18 |
| C | SER155 |
| C | GLY156 |
| C | ASP157 |
| C | GLY182 |
| C | LYS213 |
| C | GLU214 |
| C | GLY301 |
| C | GLY302 |
| C | THR303 |
| C | MET305 |
| C | TYR306 |
| C | LYS336 |
| C | MG401 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue MG D 401 |
| Chain | Residue |
| D | GLN137 |
| D | ADP402 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue ADP D 402 |
| Chain | Residue |
| D | GLY13 |
| D | SER14 |
| D | GLY15 |
| D | LEU16 |
| D | LYS18 |
| D | GLY156 |
| D | ASP157 |
| D | GLY182 |
| D | LYS213 |
| D | GLU214 |
| D | GLY301 |
| D | GLY302 |
| D | TYR306 |
| D | LYS336 |
| D | MG401 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue MG E 401 |
| Chain | Residue |
| E | ASP154 |
| E | ADP402 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for residue ADP E 402 |
| Chain | Residue |
| E | GLY13 |
| E | SER14 |
| E | GLY15 |
| E | LEU16 |
| E | LYS18 |
| E | SER155 |
| E | GLY156 |
| E | ASP157 |
| E | LYS213 |
| E | GLU214 |
| E | GLY301 |
| E | GLY302 |
| E | MET305 |
| E | TYR306 |
| E | LYS336 |
| E | MG401 |
| site_id | AD2 |
| Number of Residues | 13 |
| Details | binding site for Phalloidin chain X |
| Chain | Residue |
| E | ILE287 |
| C | THR194 |
| C | GLY197 |
| C | TYR198 |
| C | SER199 |
| C | PHE200 |
| C | GLU205 |
| C | GLN246 |
| D | GLU72 |
| D | ILE75 |
| D | THR77 |
| D | PRO112 |
| D | ARG177 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for Phalloidin chain Y |
| Chain | Residue |
| A | THR194 |
| A | GLY197 |
| A | TYR198 |
| A | SER199 |
| A | GLU205 |
| A | GLN246 |
| B | GLU72 |
| B | ILE75 |
| B | LEU110 |
| B | PRO112 |
| B | ARG177 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for Phalloidin chain Z |
| Chain | Residue |
| B | THR194 |
| B | GLY197 |
| B | TYR198 |
| B | SER199 |
| B | GLU205 |
| B | GLN246 |
| C | GLU72 |
| C | ILE75 |
| C | PRO112 |
| C | ARG177 |
| D | ILE287 |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| A | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WITKqEYDE |
| Chain | Residue | Details |
| A | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| A | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | CROSSLNK: 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys) => ECO:0000250|UniProtKB:P85421 |
| Chain | Residue | Details |
| X | TRP3 | |
| X | CYS7 | |
| Y | TRP3 | |
| Y | CYS7 | |
| Z | TRP3 | |
| Z | CYS7 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | MOD_RES: N-acetylaspartate; in Actin, alpha skeletal muscle => ECO:0000269|PubMed:456601 |
| Chain | Residue | Details |
| A | ASP1 | |
| B | ASP1 | |
| C | ASP1 | |
| D | ASP1 | |
| E | ASP1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | MOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P68134 |
| Chain | Residue | Details |
| A | MET44 | |
| E | MET47 | |
| A | MET47 | |
| B | MET44 | |
| B | MET47 | |
| C | MET44 | |
| C | MET47 | |
| D | MET44 | |
| D | MET47 | |
| E | MET44 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | MOD_RES: Tele-methylhistidine => ECO:0000269|PubMed:12356759, ECO:0007744|PDB:1MDU |
| Chain | Residue | Details |
| A | HIS73 | |
| B | HIS73 | |
| C | HIS73 | |
| D | HIS73 | |
| E | HIS73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68133 |
| Chain | Residue | Details |
| A | LYS84 | |
| B | LYS84 | |
| C | LYS84 | |
| D | LYS84 | |
| E | LYS84 |
