7BS3

Bovine Pancreatic Trypsin with 4-Bromo-benzamidine (Cryo)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0007586	biological_process	digestion
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0097180	cellular_component	serine protease inhibitor complex
A	0097655	molecular_function	serpin family protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 301

Chain	Residue
A	GLU75
A	ASN77
A	VAL80
A	GLU85
A	HOH417
A	HOH472

---

site_id	AC2
Number of Residues	9
Details	binding site for residue F5R A 302

Chain	Residue
A	SER200
A	TRP216
A	GLY217
A	GLY219
A	GLY227
A	HOH549
A	ASP194
A	SER195
A	CYS196

---

site_id	AC3
Number of Residues	7
Details	binding site for residue DMS A 303

Chain	Residue
A	ARG72
A	ILE78
A	ASN79
A	PHE87
A	VAL95
A	HIS96
A	HOH472

---

site_id	AC4
Number of Residues	7
Details	binding site for residue DMS A 304

Chain	Residue
A	PRO129
A	THR130
A	SER131
A	SER150
A	GLY151
A	LYS209
A	GLN211

---

site_id	AC5
Number of Residues	5
Details	binding site for residue DMS A 305

Chain	Residue
A	TYR45
A	HIS46
A	ILE78
A	ASN79
A	SER93

---

site_id	AC6
Number of Residues	4
Details	binding site for residue DMS A 306

Chain	Residue
A	ASN100
A	SER101
A	ASN102
A	HOH412

---

site_id	AC7
Number of Residues	5
Details	binding site for residue DMS A 307

Chain	Residue
A	TYR28
A	CYS30
A	THR34
A	VAL35
A	HOH556

---

site_id	AC8
Number of Residues	2
Details	binding site for residue DMS A 308

Chain	Residue
A	GLU85
A	PHE87

---

site_id	AC9
Number of Residues	4
Details	binding site for residue DMS A 309

Chain	Residue
A	CYS233
A	ASN234
A	VAL236
A	SER237

---

site_id	AD1
Number of Residues	5
Details	binding site for residue DMS A 310

Chain	Residue
A	ASN54
A	SER55
A	LEU119
A	ASP168
A	LYS172

---

site_id	AD2
Number of Residues	3
Details	binding site for residue DMS A 311

Chain	Residue
A	GLY68
A	SER153
A	TYR154

---

site_id	AD3
Number of Residues	6
Details	binding site for residue DMS A 312

Chain	Residue
A	ALA32
A	ASN33
A	SER121
A	ARG122
A	PRO176
A	HOH405

---

site_id	AD4
Number of Residues	3
Details	binding site for residue DMS A 313

Chain	Residue
A	ASN54
A	LEU128
A	SER169

---

site_id	AD5
Number of Residues	3
Details	binding site for residue DMS A 314

Chain	Residue
A	THR180
A	SER181
A	HOH565

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL59-CYS64

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
A	ASP194-VAL205

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

---