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7BRP

Crystal structure of the 2019-nCoV main protease complexed with Boceprevir

Functional Information from GO Data
ChainGOidnamespacecontents
A0008233molecular_functionpeptidase activity
A0019082biological_processviral protein processing
B0008233molecular_functionpeptidase activity
B0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue U5G B 401
ChainResidue
BHIS41
BASP187
BTHR190
BGLN192
BGLY251
BPRO252
BHOH641
BMET49
BASN142
BGLY143
BSER144
BCYS145
BHIS164
BMET165
BGLU166

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291
ChainResidueDetails
BHIS41
AHIS41

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291
ChainResidueDetails
BCYS145
ACYS145

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
BGLN306
AGLN306

219869

PDB entries from 2024-05-15

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