7BPY

X-ray structure of human PPARalpha ligand binding domain-clofibric acid-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue E0O A 501

Chain	Residue
A	CYS276
A	GLN277
A	SER280
A	TYR314
A	ILE354
A	HIS440
A	LEU456
A	TYR464

---

site_id	AC2
Number of Residues	8
Details	binding site for residue E0O A 502

Chain	Residue
A	LEU247
A	LEU254
A	CYS275
A	THR279
A	VAL332
A	TYR334
A	ILE339
A	ILE241

---

site_id	AC3
Number of Residues	8
Details	binding site for residue E0O C 501

Chain	Residue
C	CYS276
C	GLN277
C	SER280
C	TYR314
C	HIS440
C	ILE447
C	LEU456
C	TYR464

---

site_id	AC4
Number of Residues	4
Details	binding site for residue E0O C 502

Chain	Residue
C	LYS257
C	CYS275
C	THR279
C	ALA333

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	454
Details	Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	258
Details	Region: {"description":"Required for heterodimerization with RXRA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19116277","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ET1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Essential for heterodimerization with RXRA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Motif: {"description":"LXXLL motif 4"}

Chain

Residue

Details

---