7BPY

X-ray structure of human PPARalpha ligand binding domain-clofibric acid-SRC1 coactivator peptide co-crystals obtained by delipidation and co-crystallization

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue E0O A 501

Chain	Residue
A	CYS276
A	GLN277
A	SER280
A	TYR314
A	ILE354
A	HIS440
A	LEU456
A	TYR464

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site_id	AC2
Number of Residues	8
Details	binding site for residue E0O A 502

Chain	Residue
A	LEU247
A	LEU254
A	CYS275
A	THR279
A	VAL332
A	TYR334
A	ILE339
A	ILE241

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site_id	AC3
Number of Residues	8
Details	binding site for residue E0O C 501

Chain	Residue
C	CYS276
C	GLN277
C	SER280
C	TYR314
C	HIS440
C	ILE447
C	LEU456
C	TYR464

---

site_id	AC4
Number of Residues	4
Details	binding site for residue E0O C 502

Chain	Residue
C	LYS257
C	CYS275
C	THR279
C	ALA333

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1

Chain	Residue	Details
A	SER280
A	TYR314
A	TYR464
C	SER280
C	TYR314
C	TYR464

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Essential for heterodimerization with RXRA

Chain	Residue	Details
A	LEU433
C	LEU433

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