7BN7

Crystal structure of ene-reductase OYE2 from S. cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003959	molecular_function	NADPH dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006915	biological_process	apoptotic process
A	0010181	molecular_function	FMN binding
A	0016491	molecular_function	oxidoreductase activity
B	0003959	molecular_function	NADPH dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006915	biological_process	apoptotic process
B	0010181	molecular_function	FMN binding
B	0016491	molecular_function	oxidoreductase activity
C	0003959	molecular_function	NADPH dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0006915	biological_process	apoptotic process
C	0010181	molecular_function	FMN binding
C	0016491	molecular_function	oxidoreductase activity
D	0003959	molecular_function	NADPH dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0006915	biological_process	apoptotic process
D	0010181	molecular_function	FMN binding
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue FMN A 501

Chain	Residue
A	PRO35
A	GLY325
A	ASN326
A	GLY348
A	ARG349
A	TYR376
A	GOL502
A	HOH628
A	HOH639
A	HOH677
A	PRO36
A	LEU37
A	THR38
A	GLY73
A	GLN115
A	HIS192
A	ASN195
A	ARG244

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 502

Chain	Residue
A	HIS192
A	ASN195
A	TYR197
A	PHE251
A	PRO296
A	TYR376
A	FMN501

---

site_id	AC3
Number of Residues	19
Details	binding site for residue FMN B 501

Chain	Residue
B	PRO35
B	PRO36
B	LEU37
B	THR38
B	GLY73
B	GLN115
B	HIS192
B	ASN195
B	ARG244
B	GLY325
B	ASN326
B	GLY348
B	ARG349
B	PHE375
B	TYR376
B	GOL502
B	HOH604
B	HOH623
B	HOH643

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL B 502

Chain	Residue
B	ASN195
B	TYR197
B	PHE251
B	PRO296
B	TYR376
B	FMN501
B	HOH643

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL B 503

Chain	Residue
B	SER309
B	HOH614
D	HOH629

---

site_id	AC6
Number of Residues	19
Details	binding site for residue FMN C 501

Chain	Residue
C	PRO35
C	PRO36
C	LEU37
C	THR38
C	GLY73
C	GLN115
C	HIS192
C	ASN195
C	ARG244
C	GLY325
C	ASN326
C	GLY348
C	ARG349
C	PHE375
C	TYR376
C	GOL502
C	HOH607
C	HOH630
C	HOH638

---

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL C 502

Chain	Residue
C	TRP117
C	HIS192
C	ASN195
C	TYR197
C	PHE251
C	PRO296
C	FMN501

---

site_id	AC8
Number of Residues	18
Details	binding site for residue FMN D 501

Chain	Residue
D	PRO35
D	PRO36
D	LEU37
D	THR38
D	GLY73
D	GLN115
D	HIS192
D	ASN195
D	ARG244
D	GLY325
D	ASN326
D	GLY348
D	ARG349
D	PHE375
D	GOL502
D	HOH623
D	HOH630
D	HOH659

---

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL D 502

Chain	Residue
D	ASN195
D	TYR197
D	PHE251
D	PRO296
D	TYR376
D	FMN501
D	HIS192

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q02899

Chain	Residue	Details
A	TYR197
B	TYR197
C	TYR197
D	TYR197

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q02899

Chain	Residue	Details
A	THR38
B	HIS192
B	ASN195
B	ARG244
B	ARG349
B	TYR376
C	THR38
C	GLN115
C	HIS192
C	ASN195
C	ARG244
A	GLN115
C	ARG349
C	TYR376
D	THR38
D	GLN115
D	HIS192
D	ASN195
D	ARG244
D	ARG349
D	TYR376
A	HIS192
A	ASN195
A	ARG244
A	ARG349
A	TYR376
B	THR38
B	GLN115

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER353
B	SER353
C	SER353
D	SER353

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER379
B	SER379
C	SER379
D	SER379

---