Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7BLO

VPS26 dimer region of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015031	biological_process	protein transport
A	0030906	cellular_component	retromer, cargo-selective complex
A	0042147	biological_process	retrograde transport, endosome to Golgi
C	0015031	biological_process	protein transport
C	0030906	cellular_component	retromer, cargo-selective complex
C	0042147	biological_process	retrograde transport, endosome to Golgi
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005768	cellular_component	endosome
F	0005769	cellular_component	early endosome
F	0005829	cellular_component	cytosol
F	0006886	biological_process	intracellular protein transport
F	0010008	cellular_component	endosome membrane
F	0015031	biological_process	protein transport
F	0016241	biological_process	regulation of macroautophagy
F	0030904	cellular_component	retromer complex
F	0030906	cellular_component	retromer, cargo-selective complex
F	0031982	cellular_component	vesicle
F	0032456	biological_process	endocytic recycling
F	0042147	biological_process	retrograde transport, endosome to Golgi
F	0097422	cellular_component	tubular endosome
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005769	cellular_component	early endosome
G	0005829	cellular_component	cytosol
G	0008289	molecular_function	lipid binding
G	0009617	biological_process	response to bacterium
G	0010008	cellular_component	endosome membrane
G	0010314	molecular_function	phosphatidylinositol-5-phosphate binding
G	0010324	biological_process	membrane invagination
G	0010976	biological_process	positive regulation of neuron projection development
G	0015031	biological_process	protein transport
G	0019903	molecular_function	protein phosphatase binding
G	0022615	biological_process	protein to membrane docking
G	0030111	biological_process	regulation of Wnt signaling pathway
G	0030136	cellular_component	clathrin-coated vesicle
G	0030904	cellular_component	retromer complex
G	0031410	cellular_component	cytoplasmic vesicle
G	0031901	cellular_component	early endosome membrane
G	0032009	cellular_component	early phagosome
G	0032266	molecular_function	phosphatidylinositol-3-phosphate binding
G	0032456	biological_process	endocytic recycling
G	0034499	biological_process	late endosome to Golgi transport
G	0035091	molecular_function	phosphatidylinositol binding
G	0042177	biological_process	negative regulation of protein catabolic process
G	0045335	cellular_component	phagocytic vesicle
G	0046597	biological_process	host-mediated suppression of symbiont invasion
G	0050765	biological_process	negative regulation of phagocytosis
G	0051224	biological_process	negative regulation of protein transport
G	0070062	cellular_component	extracellular exosome
G	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
G	0070676	biological_process	intralumenal vesicle formation
G	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
G	1901981	molecular_function	phosphatidylinositol phosphate binding
G	1905394	molecular_function	retromer complex binding
G	2000642	biological_process	negative regulation of early endosome to late endosome transport
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005768	cellular_component	endosome
J	0005769	cellular_component	early endosome
J	0005829	cellular_component	cytosol
J	0006886	biological_process	intracellular protein transport
J	0010008	cellular_component	endosome membrane
J	0015031	biological_process	protein transport
J	0016241	biological_process	regulation of macroautophagy
J	0030904	cellular_component	retromer complex
J	0030906	cellular_component	retromer, cargo-selective complex
J	0031982	cellular_component	vesicle
J	0032456	biological_process	endocytic recycling
J	0042147	biological_process	retrograde transport, endosome to Golgi
J	0097422	cellular_component	tubular endosome
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005769	cellular_component	early endosome
L	0005829	cellular_component	cytosol
L	0008289	molecular_function	lipid binding
L	0009617	biological_process	response to bacterium
L	0010008	cellular_component	endosome membrane
L	0010314	molecular_function	phosphatidylinositol-5-phosphate binding
L	0010324	biological_process	membrane invagination
L	0010976	biological_process	positive regulation of neuron projection development
L	0015031	biological_process	protein transport
L	0019903	molecular_function	protein phosphatase binding
L	0022615	biological_process	protein to membrane docking
L	0030111	biological_process	regulation of Wnt signaling pathway
L	0030136	cellular_component	clathrin-coated vesicle
L	0030904	cellular_component	retromer complex
L	0031410	cellular_component	cytoplasmic vesicle
L	0031901	cellular_component	early endosome membrane
L	0032009	cellular_component	early phagosome
L	0032266	molecular_function	phosphatidylinositol-3-phosphate binding
L	0032456	biological_process	endocytic recycling
L	0034499	biological_process	late endosome to Golgi transport
L	0035091	molecular_function	phosphatidylinositol binding
L	0042177	biological_process	negative regulation of protein catabolic process
L	0045335	cellular_component	phagocytic vesicle
L	0046597	biological_process	host-mediated suppression of symbiont invasion
L	0050765	biological_process	negative regulation of phagocytosis
L	0051224	biological_process	negative regulation of protein transport
L	0070062	cellular_component	extracellular exosome
L	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
L	0070676	biological_process	intralumenal vesicle formation
L	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
L	1901981	molecular_function	phosphatidylinositol phosphate binding
L	1905394	molecular_function	retromer complex binding
L	2000642	biological_process	negative regulation of early endosome to late endosome transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Region: {"description":"Required for early endosome targeting","evidences":[{"source":"PubMed","id":"12475959","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	58
Details	Region: {"description":"Interaction with SNX3","evidences":[{"source":"PubMed","id":"24344282","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)