7BKC

Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from Methanospirillum hungatei (dimeric, composite structure)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0015948	biological_process	methanogenesis
B	0016491	molecular_function	oxidoreductase activity
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0051912	molecular_function	CoB--CoM heterodisulfide reductase activity
C	0005886	cellular_component	plasma membrane
C	0015948	biological_process	methanogenesis
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0051912	molecular_function	CoB--CoM heterodisulfide reductase activity
D	0003954	molecular_function	NADH dehydrogenase activity
D	0008863	molecular_function	formate dehydrogenase (NAD+) activity
D	0015942	biological_process	formate metabolic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0022904	biological_process	respiratory electron transport chain
D	0043546	molecular_function	molybdopterin cofactor binding
D	0046872	molecular_function	metal ion binding
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
E	0000166	molecular_function	nucleotide binding
E	0016491	molecular_function	oxidoreductase activity
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051539	molecular_function	4 iron, 4 sulfur cluster binding
E	0052592	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
F	0016491	molecular_function	oxidoreductase activity
F	0046872	molecular_function	metal ion binding
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0016491	molecular_function	oxidoreductase activity
G	0016787	molecular_function	hydrolase activity
G	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
G	0046872	molecular_function	metal ion binding
H	0003954	molecular_function	NADH dehydrogenase activity
H	0015948	biological_process	methanogenesis
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0018493	molecular_function	formylmethanofuran dehydrogenase activity
H	0019386	biological_process	methanogenesis, from carbon dioxide
H	0022904	biological_process	respiratory electron transport chain
H	0046872	molecular_function	metal ion binding
H	0051536	molecular_function	iron-sulfur cluster binding
H	0051539	molecular_function	4 iron, 4 sulfur cluster binding
I	0015948	biological_process	methanogenesis
I	0016491	molecular_function	oxidoreductase activity
I	0018493	molecular_function	formylmethanofuran dehydrogenase activity
I	0019386	biological_process	methanogenesis, from carbon dioxide
I	0046914	molecular_function	transition metal ion binding
J	0016491	molecular_function	oxidoreductase activity
J	0043546	molecular_function	molybdopterin cofactor binding
K	0016491	molecular_function	oxidoreductase activity
K	0046872	molecular_function	metal ion binding
K	0051536	molecular_function	iron-sulfur cluster binding
K	0051539	molecular_function	4 iron, 4 sulfur cluster binding
L	0016491	molecular_function	oxidoreductase activity
L	0046872	molecular_function	metal ion binding
L	0051536	molecular_function	iron-sulfur cluster binding
L	0051539	molecular_function	4 iron, 4 sulfur cluster binding
M	0016491	molecular_function	oxidoreductase activity
M	0046872	molecular_function	metal ion binding
M	0051536	molecular_function	iron-sulfur cluster binding
M	0051539	molecular_function	4 iron, 4 sulfur cluster binding
a	0000166	molecular_function	nucleotide binding
a	0016491	molecular_function	oxidoreductase activity
a	0046872	molecular_function	metal ion binding
a	0051536	molecular_function	iron-sulfur cluster binding
a	0051539	molecular_function	4 iron, 4 sulfur cluster binding
b	0015948	biological_process	methanogenesis
b	0016491	molecular_function	oxidoreductase activity
b	0051536	molecular_function	iron-sulfur cluster binding
b	0051539	molecular_function	4 iron, 4 sulfur cluster binding
b	0051912	molecular_function	CoB--CoM heterodisulfide reductase activity
c	0005886	cellular_component	plasma membrane
c	0015948	biological_process	methanogenesis
c	0016491	molecular_function	oxidoreductase activity
c	0046872	molecular_function	metal ion binding
c	0051536	molecular_function	iron-sulfur cluster binding
c	0051539	molecular_function	4 iron, 4 sulfur cluster binding
c	0051912	molecular_function	CoB--CoM heterodisulfide reductase activity
d	0003954	molecular_function	NADH dehydrogenase activity
d	0008863	molecular_function	formate dehydrogenase (NAD+) activity
d	0015942	biological_process	formate metabolic process
d	0016020	cellular_component	membrane
d	0016491	molecular_function	oxidoreductase activity
d	0022904	biological_process	respiratory electron transport chain
d	0043546	molecular_function	molybdopterin cofactor binding
d	0046872	molecular_function	metal ion binding
d	0051536	molecular_function	iron-sulfur cluster binding
d	0051539	molecular_function	4 iron, 4 sulfur cluster binding
e	0000166	molecular_function	nucleotide binding
e	0016491	molecular_function	oxidoreductase activity
e	0046872	molecular_function	metal ion binding
e	0051536	molecular_function	iron-sulfur cluster binding
e	0051539	molecular_function	4 iron, 4 sulfur cluster binding
e	0052592	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
f	0016491	molecular_function	oxidoreductase activity
f	0046872	molecular_function	metal ion binding
f	0051536	molecular_function	iron-sulfur cluster binding
f	0051537	molecular_function	2 iron, 2 sulfur cluster binding
g	0016491	molecular_function	oxidoreductase activity
g	0016787	molecular_function	hydrolase activity
g	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
g	0046872	molecular_function	metal ion binding
h	0003954	molecular_function	NADH dehydrogenase activity
h	0015948	biological_process	methanogenesis
h	0016020	cellular_component	membrane
h	0016491	molecular_function	oxidoreductase activity
h	0018493	molecular_function	formylmethanofuran dehydrogenase activity
h	0019386	biological_process	methanogenesis, from carbon dioxide
h	0022904	biological_process	respiratory electron transport chain
h	0046872	molecular_function	metal ion binding
h	0051536	molecular_function	iron-sulfur cluster binding
h	0051539	molecular_function	4 iron, 4 sulfur cluster binding
i	0015948	biological_process	methanogenesis
i	0016491	molecular_function	oxidoreductase activity
i	0018493	molecular_function	formylmethanofuran dehydrogenase activity
i	0019386	biological_process	methanogenesis, from carbon dioxide
i	0046914	molecular_function	transition metal ion binding
j	0016491	molecular_function	oxidoreductase activity
j	0043546	molecular_function	molybdopterin cofactor binding
k	0016491	molecular_function	oxidoreductase activity
k	0046872	molecular_function	metal ion binding
k	0051536	molecular_function	iron-sulfur cluster binding
k	0051539	molecular_function	4 iron, 4 sulfur cluster binding
l	0016491	molecular_function	oxidoreductase activity
l	0046872	molecular_function	metal ion binding
l	0051536	molecular_function	iron-sulfur cluster binding
l	0051539	molecular_function	4 iron, 4 sulfur cluster binding
m	0016491	molecular_function	oxidoreductase activity
m	0046872	molecular_function	metal ion binding
m	0051536	molecular_function	iron-sulfur cluster binding
m	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CtGCNnCVvACP

Chain	Residue	Details
L	CYS73-PRO84
A	CYS261-PRO272
A	CYS308-GLY319
A	CYS600-PRO611
A	CYS633-PRO644
E	CYS293-PRO304
E	CYS342-PRO353
C	CYS44-PRO55
C	CYS88-PRO99
L	CYS119-PRO130
M	CYS37-PRO48
M	CYS78-PRO89
M	CYS125-PRO136
M	CYS174-GLU185
M	CYS212-PRO223
M	CYS249-PRO260
M	CYS323-PRO334

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site_id	PS00490
Number of Residues	18
Details	MOLYBDOPTERIN_PROK_2 Prokaryotic molybdopterin oxidoreductases signature 2. TeTCqyADVILPgACfaE

Chain	Residue	Details
D	THR431-GLU448

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site_id	PS00551
Number of Residues	18
Details	MOLYBDOPTERIN_PROK_1 Prokaryotic molybdopterin oxidoreductases signature 1. TtCpy.CGVgCtLnLvvs.N

Chain	Residue	Details
D	THR13-ASN30

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site_id	PS00932
Number of Residues	28
Details	MOLYBDOPTERIN_PROK_3 Prokaryotic molybdopterin oxidoreductases signature 3. ArrlGIkNnEyIkLkSrrGetttlArVT

Chain	Residue	Details
D	ALA611-THR638

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