7BK9

Crystal structure of 3-hydroxydecanoyl-acyl carrier protein dehydratase (FabA) from Pseudomonas aeruginosa in complex with DDD00078426

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006633	biological_process	fatty acid biosynthetic process
A	0006636	biological_process	unsaturated fatty acid biosynthetic process
A	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
B	0005737	cellular_component	cytoplasm
B	0006633	biological_process	fatty acid biosynthetic process
B	0006636	biological_process	unsaturated fatty acid biosynthetic process
B	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
C	0005737	cellular_component	cytoplasm
C	0006633	biological_process	fatty acid biosynthetic process
C	0006636	biological_process	unsaturated fatty acid biosynthetic process
C	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
C	0016829	molecular_function	lyase activity
C	0016853	molecular_function	isomerase activity
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
D	0005737	cellular_component	cytoplasm
D	0006633	biological_process	fatty acid biosynthetic process
D	0006636	biological_process	unsaturated fatty acid biosynthetic process
D	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
D	0016829	molecular_function	lyase activity
D	0016853	molecular_function	isomerase activity
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
E	0005737	cellular_component	cytoplasm
E	0006633	biological_process	fatty acid biosynthetic process
E	0006636	biological_process	unsaturated fatty acid biosynthetic process
E	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
E	0016829	molecular_function	lyase activity
E	0016853	molecular_function	isomerase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue U0W A 201

Chain	Residue
A	HIS70
A	TYR155
A	PHE171
A	HOH306
B	U0W202
A	MET77
A	PRO78
A	GLY79
A	ARG104
A	ALA105
A	PHE114
A	GLY115
A	GLN116

---

site_id	AC2
Number of Residues	12
Details	binding site for residue U0W B 201

Chain	Residue
B	ARG104
B	ALA105
B	PHE165
B	PHE171
B	HOH303
C	HIS70
C	MET77
C	PRO78
C	GLY79
C	PHE114
C	GLY115
D	U0W202

---

site_id	AC3
Number of Residues	5
Details	binding site for residue U0W B 202

Chain	Residue
A	LYS112
A	U0W201
B	LYS48
B	TYR49
B	GLY50

---

site_id	AC4
Number of Residues	9
Details	binding site for residue U0W B 203

Chain	Residue
B	HIS70
B	MET77
B	PRO78
B	GLY79
B	PHE113
B	GLY115
C	ARG104
C	ALA105
C	HOH202

---

site_id	AC5
Number of Residues	9
Details	binding site for residue U0W D 201

Chain	Residue
D	ARG104
D	ALA105
D	HOH302
E	HIS70
E	MET77
E	PRO78
E	GLY79
E	PHE114
E	GLY115

---

site_id	AC6
Number of Residues	8
Details	binding site for residue U0W D 202

Chain	Residue
B	LEU138
B	PHE171
B	U0W201
C	LYS112
D	GLY46
D	LYS48
D	TYR49
D	GLY50

---

site_id	AC7
Number of Residues	11
Details	binding site for residue U0W E 201

Chain	Residue
D	HIS70
D	MET77
D	PRO78
D	GLY79
D	PHE114
D	GLY115
E	ARG104
E	ALA105
E	PHE165
E	PHE171
E	HOH303

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS70
B	HIS70
D	HIS70
C	HIS70
E	HIS70

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