Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7BF2

Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended 1:2 binding mode

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000086	biological_process	G2/M transition of mitotic cell cycle
AAA	0000922	cellular_component	spindle pole
AAA	0002027	biological_process	regulation of heart rate
AAA	0005509	molecular_function	calcium ion binding
AAA	0005513	biological_process	detection of calcium ion
AAA	0005515	molecular_function	protein binding
AAA	0005576	cellular_component	extracellular region
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005737	cellular_component	cytoplasm
AAA	0005813	cellular_component	centrosome
AAA	0005819	cellular_component	spindle
AAA	0005829	cellular_component	cytosol
AAA	0005856	cellular_component	cytoskeleton
AAA	0005876	cellular_component	spindle microtubule
AAA	0005886	cellular_component	plasma membrane
AAA	0007186	biological_process	G protein-coupled receptor signaling pathway
AAA	0008076	cellular_component	voltage-gated potassium channel complex
AAA	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
AAA	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
AAA	0010856	molecular_function	adenylate cyclase activator activity
AAA	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
AAA	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
AAA	0016020	cellular_component	membrane
AAA	0016240	biological_process	autophagosome membrane docking
AAA	0019855	molecular_function	calcium channel inhibitor activity
AAA	0019901	molecular_function	protein kinase binding
AAA	0021762	biological_process	substantia nigra development
AAA	0030017	cellular_component	sarcomere
AAA	0031432	molecular_function	titin binding
AAA	0031514	cellular_component	motile cilium
AAA	0031954	biological_process	positive regulation of protein autophosphorylation
AAA	0031982	cellular_component	vesicle
AAA	0032465	biological_process	regulation of cytokinesis
AAA	0032516	biological_process	obsolete positive regulation of phosphoprotein phosphatase activity
AAA	0032991	cellular_component	protein-containing complex
AAA	0034704	cellular_component	calcium channel complex
AAA	0035307	biological_process	obsolete positive regulation of protein dephosphorylation
AAA	0035458	biological_process	cellular response to interferon-beta
AAA	0043209	cellular_component	myelin sheath
AAA	0043539	molecular_function	protein serine/threonine kinase activator activity
AAA	0044305	cellular_component	calyx of Held
AAA	0044325	molecular_function	transmembrane transporter binding
AAA	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
AAA	0046872	molecular_function	metal ion binding
AAA	0048306	molecular_function	calcium-dependent protein binding
AAA	0050848	biological_process	regulation of calcium-mediated signaling
AAA	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
AAA	0051592	biological_process	response to calcium ion
AAA	0055117	biological_process	regulation of cardiac muscle contraction
AAA	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
AAA	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
AAA	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
AAA	0071346	biological_process	cellular response to type II interferon
AAA	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
AAA	0072542	molecular_function	protein phosphatase activator activity
AAA	0097225	cellular_component	sperm midpiece
AAA	0098901	biological_process	regulation of cardiac muscle cell action potential
AAA	0099523	cellular_component	presynaptic cytosol
AAA	0140056	biological_process	organelle localization by membrane tethering
AAA	0140238	biological_process	presynaptic endocytosis
AAA	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
AAA	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
AAA	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
AAA	1902494	cellular_component	catalytic complex
AAA	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
AAA	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
AAA	ASP21-LEU33
AAA	ASP57-PHE69
AAA	ASP94-LEU106
AAA	ASP130-PHE142

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P00564

Chain	Residue	Details
CCC	THR313
AAA	GLU68
DDD	THR313
AAA	ASP25
AAA	THR27
AAA	GLU32
AAA	ASP57
AAA	ASP59
AAA	ASN61
AAA	THR63

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448, ECO:0000269\|PubMed:1474585, ECO:0000269\|PubMed:27564677, ECO:0000269\|PubMed:29724949, ECO:0007744\|PDB:1CLL, ECO:0007744\|PDB:5J03, ECO:0007744\|PDB:6CNN, ECO:0007744\|PDB:6CNO

Chain	Residue	Details
AAA	ASP94
AAA	ASP96
AAA	ASN98
AAA	TYR100
AAA	GLU105

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448, ECO:0000269\|PubMed:1474585, ECO:0000269\|PubMed:27564677, ECO:0007744\|PDB:1CLL, ECO:0007744\|PDB:5J03

Chain	Residue	Details
AAA	ASP130
AAA	ASP132
AAA	ASP134
AAA	GLN136
AAA	GLU141

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:7093203, ECO:0000269\|Ref.7, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
AAA	ALA2

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
AAA	LYS22

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250\|UniProtKB:P0DP29

Chain	Residue	Details
AAA	THR45

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
AAA	SER82

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
AAA	LYS95

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332

Chain	Residue	Details
AAA	TYR100

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
AAA	SER102

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
AAA	THR111

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744\|PubMed:24129315

Chain	Residue	Details
AAA	LYS116

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
AAA	TYR139

site_id	SWS_FT_FI14
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P62157

Chain	Residue	Details
AAA	LYS22

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)