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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7BF2

Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended 1:2 binding mode

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AAA0000086biological_processG2/M transition of mitotic cell cycle
AAA0000922cellular_componentspindle pole
AAA0002027biological_processregulation of heart rate
AAA0005246molecular_functioncalcium channel regulator activity
AAA0005509molecular_functioncalcium ion binding
AAA0005513biological_processdetection of calcium ion
AAA0005515molecular_functionprotein binding
AAA0005576cellular_componentextracellular region
AAA0005634cellular_componentnucleus
AAA0005654cellular_componentnucleoplasm
AAA0005737cellular_componentcytoplasm
AAA0005813cellular_componentcentrosome
AAA0005819cellular_componentspindle
AAA0005829cellular_componentcytosol
AAA0005876cellular_componentspindle microtubule
AAA0005886cellular_componentplasma membrane
AAA0007186biological_processG protein-coupled receptor signaling pathway
AAA0008076cellular_componentvoltage-gated potassium channel complex
AAA0010856molecular_functionadenylate cyclase activator activity
AAA0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
AAA0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
AAA0016020cellular_componentmembrane
AAA0016240biological_processautophagosome membrane docking
AAA0019855molecular_functioncalcium channel inhibitor activity
AAA0019901molecular_functionprotein kinase binding
AAA0021762biological_processsubstantia nigra development
AAA0030017cellular_componentsarcomere
AAA0030672cellular_componentsynaptic vesicle membrane
AAA0031432molecular_functiontitin binding
AAA0031514cellular_componentmotile cilium
AAA0031982cellular_componentvesicle
AAA0032465biological_processregulation of cytokinesis
AAA0032991cellular_componentprotein-containing complex
AAA0034704cellular_componentcalcium channel complex
AAA0035458biological_processcellular response to interferon-beta
AAA0043209cellular_componentmyelin sheath
AAA0043539molecular_functionprotein serine/threonine kinase activator activity
AAA0044305cellular_componentcalyx of Held
AAA0044325molecular_functiontransmembrane transporter binding
AAA0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
AAA0046872molecular_functionmetal ion binding
AAA0048306molecular_functioncalcium-dependent protein binding
AAA0050848biological_processregulation of calcium-mediated signaling
AAA0051592biological_processresponse to calcium ion
AAA0055117biological_processregulation of cardiac muscle contraction
AAA0060291biological_processlong-term synaptic potentiation
AAA0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
AAA0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
AAA0071346biological_processcellular response to type II interferon
AAA0072542molecular_functionprotein phosphatase activator activity
AAA0097225cellular_componentsperm midpiece
AAA0097720biological_processcalcineurin-mediated signaling
AAA0098901biological_processregulation of cardiac muscle cell action potential
AAA0099523cellular_componentpresynaptic cytosol
AAA0140056biological_processorganelle localization by membrane tethering
AAA0140238biological_processpresynaptic endocytosis
AAA0141110molecular_functiontransporter inhibitor activity
AAA1901842biological_processnegative regulation of high voltage-gated calcium channel activity
AAA1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
AAA1902494cellular_componentcatalytic complex
AAA1905913biological_processnegative regulation of calcium ion export across plasma membrane
AAA1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
AAAASP21-LEU33
AAAASP57-PHE69
AAAASP94-LEU106
AAAASP130-PHE142
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues35
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues35
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues35
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V0C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29724949","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP29","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P00564","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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