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7BC4

Cryo-EM structure of fatty acid synthase (FAS) from Pichia pastoris

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003824molecular_functioncatalytic activity
A0004312molecular_functionfatty acid synthase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0004321molecular_functionfatty-acyl-CoA synthase activity
A0005835cellular_componentfatty acid synthase complex
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0042759biological_processlong-chain fatty acid biosynthetic process
A0046872molecular_functionmetal ion binding
A0101026biological_processmitotic nuclear membrane biogenesis
A1900535biological_processpalmitic acid biosynthetic process
B0003824molecular_functioncatalytic activity
B0004312molecular_functionfatty acid synthase activity
B0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
B0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
B0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
B0004321molecular_functionfatty-acyl-CoA synthase activity
B0005835cellular_componentfatty acid synthase complex
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0016297molecular_functionfatty acyl-[ACP] hydrolase activity
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
B0016787molecular_functionhydrolase activity
B0016829molecular_functionlyase activity
B0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL
ChainResidueDetails
ALEU173-LEU188

site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATAveSV
ChainResidueDetails
AGLY1283-VAL1299

238268

PDB entries from 2025-07-02

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