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7BB6

AVP-V2R-Galphas-beta1-gamma2-Nb35 (L state)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001992biological_processregulation of systemic arterial blood pressure by vasopressin
A0003084biological_processpositive regulation of systemic arterial blood pressure
A0003092biological_processrenal water retention
A0004930molecular_functionG protein-coupled receptor activity
A0005000molecular_functionvasopressin receptor activity
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007599biological_processhemostasis
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0021537biological_processtelencephalon development
A0030139cellular_componentendocytic vesicle
A0030669cellular_componentclathrin-coated endocytic vesicle membrane
A0032870biological_processcellular response to hormone stimulus
A0034097biological_processresponse to cytokine
A0035811biological_processnegative regulation of urine volume
A0038023molecular_functionsignaling receptor activity
A0042277molecular_functionpeptide binding
A0045777biological_processpositive regulation of blood pressure
A0045907biological_processpositive regulation of vasoconstriction
A0048471cellular_componentperinuclear region of cytoplasm
A1902533biological_processpositive regulation of intracellular signal transduction
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
E0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
E0003091biological_processrenal water homeostasis
E0003924molecular_functionGTPase activity
E0003925molecular_functionG protein activity
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005834cellular_componentheterotrimeric G-protein complex
E0005886cellular_componentplasma membrane
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
E0007190biological_processactivation of adenylate cyclase activity
E0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
E0007608biological_processsensory perception of smell
E0010856molecular_functionadenylate cyclase activator activity
E0016020cellular_componentmembrane
E0019001molecular_functionguanyl nucleotide binding
E0031683molecular_functionG-protein beta/gamma-subunit complex binding
E0031748molecular_functionD1 dopamine receptor binding
E0032588cellular_componenttrans-Golgi network membrane
E0046872molecular_functionmetal ion binding
E0046907biological_processintracellular transport
E0048589biological_processdevelopmental growth
E0050796biological_processregulation of insulin secretion
E0050890biological_processcognition
E0060348biological_processbone development
E0060789biological_processhair follicle placode formation
E0070062cellular_componentextracellular exosome
E0070527biological_processplatelet aggregation
E0071377biological_processcellular response to glucagon stimulus
E0071380biological_processcellular response to prostaglandin E stimulus
E0071870biological_processcellular response to catecholamine stimulus
E0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
E0120162biological_processpositive regulation of cold-induced thermogenesis
F0005515molecular_functionprotein binding
F0005834cellular_componentheterotrimeric G-protein complex
F0005886cellular_componentplasma membrane
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
F0016020cellular_componentmembrane
F0031681molecular_functionG-protein beta-subunit binding
F0048144biological_processfibroblast proliferation
F0070062cellular_componentextracellular exosome
F0071380biological_processcellular response to prostaglandin E stimulus
F0071870biological_processcellular response to catecholamine stimulus
H0005185molecular_functionneurohypophyseal hormone activity
H0005576cellular_componentextracellular region
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASSyMILAMTLDRHRaI
ChainResidueDetails
AALA125-ILE141

site_idPS00264
Number of Residues9
DetailsNEUROHYPOPHYS_HORM Neurohypophysial hormones signature. CYFqNCPrG
ChainResidueDetails
HCYS1-GLY9

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Important for agonist activity on V1aR/AVPR1A => ECO:0000269|PubMed:18174156
ChainResidueDetails
HGLY9
ESER54
ELEU197
ETHR204
EASP223
EASN292
EALA366

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Glycine amide => ECO:0000269|PubMed:13591312
ChainResidueDetails
HGLY9
AASP136-PRO159
AILE221-ARG271
ASER329-SER371

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
FCYS68

site_idSWS_FT_FI4
Number of Residues1
DetailsLIPID: N-palmitoyl glycine => ECO:0000250|UniProtKB:P04896
ChainResidueDetails
EGLY2
AARG181-TRP200
AALA294-VAL308

site_idSWS_FT_FI5
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21044946
ChainResidueDetails
ECYS3

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ELYS300

site_idSWS_FT_FI7
Number of Residues19
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
AGLY201-GLY220

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
AMET272-TRP293

site_idSWS_FT_FI9
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
ALEU309-PHE328

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:9224808
ChainResidueDetails
ACYS341
ACYS342

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLN14

222926

PDB entries from 2024-07-24

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