7B64

Structure of NUDT15 V18I Mutant in complex with TH7755

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000278	biological_process	mitotic cell cycle
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006195	biological_process	purine nucleotide catabolic process
A	0006203	biological_process	dGTP catabolic process
A	0006950	biological_process	response to stress
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0036217	molecular_function	dGTP diphosphatase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042262	biological_process	DNA protection
A	0044715	molecular_function	8-oxo-dGDP phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
A	0120557	molecular_function	farnesyl diphosphatase activity
A	1901292	biological_process	nucleoside phosphate catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	21
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26238318","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BON","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38944687","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7R0D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26238318","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38944687","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7R0D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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