7B4L
CryoEM structure of the human sodium proton exchanger NHA2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005929 | cellular_component | cilium |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010348 | molecular_function | lithium:proton antiporter activity |
| A | 0010351 | biological_process | lithium ion transport |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015385 | molecular_function | sodium:proton antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0030317 | biological_process | flagellated sperm motility |
| A | 0030672 | cellular_component | synaptic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031514 | cellular_component | motile cilium |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042995 | cellular_component | cell projection |
| A | 0045202 | cellular_component | synapse |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0055078 | biological_process | sodium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0061178 | biological_process | regulation of insulin secretion involved in cellular response to glucose stimulus |
| A | 0072583 | biological_process | clathrin-dependent endocytosis |
| A | 0097228 | cellular_component | sperm principal piece |
| A | 0097708 | cellular_component | intracellular vesicle |
| A | 0098662 | biological_process | inorganic cation transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 2001206 | biological_process | positive regulation of osteoclast development |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0005768 | cellular_component | endosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005929 | cellular_component | cilium |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0010348 | molecular_function | lithium:proton antiporter activity |
| B | 0010351 | biological_process | lithium ion transport |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015385 | molecular_function | sodium:proton antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0030317 | biological_process | flagellated sperm motility |
| B | 0030672 | cellular_component | synaptic vesicle membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031514 | cellular_component | motile cilium |
| B | 0031966 | cellular_component | mitochondrial membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042995 | cellular_component | cell projection |
| B | 0045202 | cellular_component | synapse |
| B | 0055037 | cellular_component | recycling endosome |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0055078 | biological_process | sodium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0061178 | biological_process | regulation of insulin secretion involved in cellular response to glucose stimulus |
| B | 0072583 | biological_process | clathrin-dependent endocytosis |
| B | 0097228 | cellular_component | sperm principal piece |
| B | 0097708 | cellular_component | intracellular vesicle |
| B | 0098662 | biological_process | inorganic cation transmembrane transport |
| B | 1902600 | biological_process | proton transmembrane transport |
| B | 2001206 | biological_process | positive regulation of osteoclast development |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 102 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 194 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"UniProtKB","id":"A0A6P3HVI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2020","submissionDatabase":"PDB data bank","title":"CryoEM structure of the human sodium proton exchanger NHA2.","authors":["Woehlert D.","Kuhlbrandt W.","Yildiz O."]}},{"source":"PDB","id":"7B4L","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
