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7B4L

CryoEM structure of the human sodium proton exchanger NHA2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006814biological_processsodium ion transport
A0010008cellular_componentendosome membrane
A0010348molecular_functionlithium:proton antiporter activity
A0010351biological_processlithium ion transport
A0015297molecular_functionantiporter activity
A0015385molecular_functionsodium:proton antiporter activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0030317biological_processflagellated sperm motility
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031966cellular_componentmitochondrial membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0045202cellular_componentsynapse
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0055078biological_processsodium ion homeostasis
A0055085biological_processtransmembrane transport
A0061178biological_processregulation of insulin secretion involved in cellular response to glucose stimulus
A0072583biological_processclathrin-dependent endocytosis
A0097228cellular_componentsperm principal piece
A0097708cellular_componentintracellular vesicle
A0098662biological_processinorganic cation transmembrane transport
A1902600biological_processproton transmembrane transport
A2001206biological_processpositive regulation of osteoclast development
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006814biological_processsodium ion transport
B0010008cellular_componentendosome membrane
B0010348molecular_functionlithium:proton antiporter activity
B0010351biological_processlithium ion transport
B0015297molecular_functionantiporter activity
B0015385molecular_functionsodium:proton antiporter activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0030317biological_processflagellated sperm motility
B0030672cellular_componentsynaptic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031514cellular_componentmotile cilium
B0031966cellular_componentmitochondrial membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0045202cellular_componentsynapse
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0055078biological_processsodium ion homeostasis
B0055085biological_processtransmembrane transport
B0061178biological_processregulation of insulin secretion involved in cellular response to glucose stimulus
B0072583biological_processclathrin-dependent endocytosis
B0097228cellular_componentsperm principal piece
B0097708cellular_componentintracellular vesicle
B0098662biological_processinorganic cation transmembrane transport
B1902600biological_processproton transmembrane transport
B2001206biological_processpositive regulation of osteoclast development
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues418
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AMET1-ARG86
BLEU134-PRO144
BLEU190-LEU200
BALA243-LEU270
BGLN325-ARG339
BALA374-ALA390
BCYS441-ALA461
BGLY510-VAL537
ALEU134-PRO144
ALEU190-LEU200
AALA243-LEU270
AGLN325-ARG339
AALA374-ALA390
ACYS441-ALA461
AGLY510-VAL537
BMET1-ARG86

site_idSWS_FT_FI2
Number of Residues34
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
AVAL87-ILE104
BVAL87-ILE104

site_idSWS_FT_FI3
Number of Residues102
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
ATHR105-GLY113
BGLY228-TRP233
BGLY291-VAL300
BGLY358-GLY361
BSER412-THR417
BTHR474-TYR486
AILE162-LYS171
AGLY228-TRP233
AGLY291-VAL300
AGLY358-GLY361
ASER412-THR417
ATHR474-TYR486
BTHR105-GLY113
BILE162-LYS171

site_idSWS_FT_FI4
Number of Residues38
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
AASN114-GLY133
BASN114-GLY133

site_idSWS_FT_FI5
Number of Residues32
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
ASER145-VAL161
BSER145-VAL161

site_idSWS_FT_FI6
Number of Residues34
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
ATRP172-GLY189
BTRP172-GLY189

site_idSWS_FT_FI7
Number of Residues52
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
ALYS201-LEU227
BLYS201-LEU227

site_idSWS_FT_FI8
Number of Residues16
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
AGLY234-GLY242
BGLY234-GLY242

site_idSWS_FT_FI9
Number of Residues38
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
ALEU271-LEU290
BLEU271-LEU290

site_idSWS_FT_FI10
Number of Residues46
DetailsTRANSMEM: Helical; Name=8 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
APHE301-ILE324
BPHE301-ILE324

site_idSWS_FT_FI11
Number of Residues34
DetailsTRANSMEM: Helical; Name=9 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
ATHR340-PHE357
BTHR340-PHE357

site_idSWS_FT_FI12
Number of Residues22
DetailsTRANSMEM: Helical; Name=10 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
ASER362-LEU373
BSER362-LEU373

site_idSWS_FT_FI13
Number of Residues40
DetailsTRANSMEM: Helical; Name=11 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
AVAL391-ALA411
BVAL391-ALA411

site_idSWS_FT_FI14
Number of Residues44
DetailsTRANSMEM: Helical; Name=12 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
AVAL418-VAL440
BVAL418-VAL440

site_idSWS_FT_FI15
Number of Residues22
DetailsTRANSMEM: Helical; Name=13 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
ATHR462-ASP473
BTHR462-ASP473

site_idSWS_FT_FI16
Number of Residues44
DetailsTRANSMEM: Helical; Name=14 => ECO:0000250|UniProtKB:A0A6P3HVI0
ChainResidueDetails
AGLY487-ILE509
BGLY487-ILE509

site_idSWS_FT_FI17
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|Ref.12, ECO:0000312|PDB:7B4L
ChainResidueDetails
AVAL244
AGLY275
AASP278
AASP279
BVAL244
BGLY275
BASP278
BASP279

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER49
BSER49

237735

PDB entries from 2025-06-18

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